D.E. Shaw & Co’s Ionis Pharmaceuticals IONS Stock Holding History

D.E. Shaw & Co’s Portfolio IONS Stock Details IONS Fund Activity

Bought

Maintained

Sold

Quarter	Market Value	Status	Shares	Change in Stake	Trade Value	Portfolio Weight	Portfolio Position
2021 Q1	–	Sell	-38,900	Closed	-$2.2M	–	4260
2020 Q4	$2.2M	Hold	38,900	–	–	﹤0.01%	2495
2020 Q3	$1.85M	Hold	38,900	–	–	﹤0.01%	2459
2020 Q2	$2.29M	Hold	38,900	–	–	﹤0.01%	2310
2020 Q1	$1.84M	Hold	38,900	–	–	﹤0.01%	2236
2019 Q4	$2.35M	Hold	38,900	–	–	﹤0.01%	2336
2019 Q3	$2.33M	Hold	38,900	–	–	﹤0.01%	2242
2019 Q2	$2.5M	Buy	38,900 +8,900	+30%	+$629K	﹤0.01%	2081
2019 Q1	$2.44M	Buy	+30,000	New	+$1.94M	﹤0.01%	2021
2016 Q1	–	Sell	-8,200	Closed	-$508K	–	3592
2015 Q4	$508K	Hold	8,200	–	–	﹤0.01%	3080
2015 Q3	$331K	Hold	8,200	–	–	﹤0.01%	3307
2015 Q2	$472K	Sell	8,200 -5,000	-38%	-$318K	﹤0.01%	3192
2015 Q1	$840K	Sell	13,200 -28,600	-68%	-$1.94M	﹤0.01%	2700
2014 Q4	$2.58M	Buy	41,800 +5,000	+14%	+$247K	﹤0.01%	2066
2014 Q3	$1.43M	Sell	36,800 -8,100	-18%	-$287K	﹤0.01%	2501
2014 Q2	$1.55M	Sell	44,900 -30,000	-40%	-$945K	﹤0.01%	2542
2014 Q1	$3.24M	Buy	74,900 +26,700	+55%	+$1.29M	﹤0.01%	1929
2013 Q4	$1.92M	Buy	48,200 +8,200	+21%	+$292K	﹤0.01%	2566
2013 Q3	$1.5M	Buy	+40,000	New	+$1.19M	﹤0.01%	2679

Other funds holding IONS

Fidelity Investments Boston, Massachusetts $1.9T AUM 41.92% 1-Year Est. Return

Capital World Investors Los Angeles, California $733B AUM 35.63% 1-Year Est. Return

BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return

VPM

Vanguard Portfolio Management Malvern, Pennsylvania $1.91T AUM

VCM

Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM

Wellington Management Group Boston, Massachusetts $535B AUM 26.23% 1-Year Est. Return

T. Rowe Price Investment Management Baltimore, Maryland $145B AUM 22.78% 1-Year Est. Return

Two Sigma Investments New York $124B AUM 33.93% 1-Year Est. Return

Geode Capital Management Boston, Massachusetts $1.61T AUM 30.72% 1-Year Est. Return

State Street Boston, Massachusetts $2.9T AUM 29.55% 1-Year Est. Return

D.E. Shaw & Co's IONS Position: Q1 2026 in Review

D.E. Shaw & Co increased its Ionis Pharmaceuticals (IONS) stake by 29% in Q1 2026, buying an estimated $7.64M and bringing the position to 429,599 shares worth $32.3M. The position accounts for 0.02% of the portfolio, ranked #888.

D.E. Shaw & Co first reported a position in IONS in Q2 2013 and has held it in 45 quarters since. The position peaked at $49.7M in Q3 2019. 493 funds tracked by Wall St. Rank hold IONS as of Q1 2026.

D.E. Shaw & Co held 429,599 shares of Ionis Pharmaceuticals worth $32.3M as of Q1 2026.
D.E. Shaw & Co bought 96,796 Ionis Pharmaceuticals shares in Q1 2026, an estimated $7.64M.
Ionis Pharmaceuticals made up 0.02% of D.E. Shaw & Co's portfolio in Q1 2026, its #888 holding.
D.E. Shaw & Co first reported a position in Ionis Pharmaceuticals in Q2 2013 and has held it in 45 quarters since.
D.E. Shaw & Co's Ionis Pharmaceuticals position peaked at $49.7M in Q3 2019.
493 funds tracked by Wall St. Rank held Ionis Pharmaceuticals as of Q1 2026.

Based on D.E. Shaw & Co's 13F filing for Q1 2026, filed 15 May 2026.