Caption Management’s Spyre Therapeutics SYRE Stock Holding History

Caption Management’s Portfolio SYRE Stock Details SYRE Fund Activity

Bought

Maintained

Sold

Quarter	Market Value	Status	Shares	Change in Stake	Trade Value	Portfolio Weight	Portfolio Position
2026 Q2	$15.4M	Buy	+173,700	New	+$12.7M	0.07%	291
2025 Q4	–	Sell	-50,000	Closed	-$838K	–	2048
2025 Q3	$838K	Buy	50,000 +10,000	+25%	+$163K	0.01%	1162
2025 Q2	$599K	Buy	+40,000	New	+$592K	0.01%	1066

Other funds holding SYRE

Fidelity Investments Boston, Massachusetts $2.3T AUM 54.33% 1-Year Est. Return

BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return

Perceptive Advisors New York $6.66B AUM 360.84% 1-Year Est. Return

RTW Investments New York $11.7B AUM 174.13% 1-Year Est. Return

PBA

Paradigm Biocapital Advisors New York $5.34B AUM 380.18% 1-Year Est. Return

Vanguard Capital Management Malvern, Pennsylvania $4.68T AUM

State Street Boston, Massachusetts $3.37T AUM 44.26% 1-Year Est. Return

VR Adviser New York $3.3B AUM 525.74% 1-Year Est. Return

T. Rowe Price Associates Baltimore, Maryland $999B AUM 46.22% 1-Year Est. Return

DCM

Driehaus Capital Management Chicago, Illinois $17.3B AUM 211.34% 1-Year Est. Return

Caption Management's SYRE Position: Q2 2026 in Review

Caption Management opened a new position in Spyre Therapeutics (SYRE) in Q2 2026: 36,000 shares worth $3.2M. The stake represents 0.01% of the portfolio and ranks #740 among its holdings.

266 funds tracked by Wall St. Rank hold SYRE as of Q2 2026.

Caption Management held 36,000 shares of Spyre Therapeutics worth $3.2M as of Q2 2026.
Spyre Therapeutics was a new Caption Management position in Q2 2026.
Spyre Therapeutics made up 0.01% of Caption Management's portfolio in Q2 2026, its #740 holding.
266 funds tracked by Wall St. Rank held Spyre Therapeutics as of Q2 2026.

Based on Caption Management's 13F filing for Q2 2026, filed 14 Aug 2026.