|
26
|
Kohlberg Kravis Roberts & Co
New York
|
$689M
|
$0
|
1
|
11.54%
|
Maintained
|
|
|
27
|
|
$640M
|
+$27.1M
|
35
|
0.1%
|
Increased
|
|
|
28
|
|
$607M
|
+$22.8M
|
69
|
0.04%
|
Increased
|
|
|
29
|
Citadel Advisors
Miami,
Florida
|
$554M
|
+$159M
|
63
|
0.08%
|
Increased
|
|
|
30
|
|
$542M
|
+$43.8M
|
23
|
0.31%
|
Increased
|
|
|
31
|
Charles Schwab
San Francisco,
California
|
$517M
|
+$29.7M
|
44
|
0.08%
|
Increased
|
|
|
32
|
Renaissance Technologies
New York
|
$500M
|
-$7.87M
|
59
|
0.66%
|
Reduced
|
|
|
33
|
Farallon Capital Management
San Francisco,
California
|
$496M
|
+$19M
|
8
|
2.03%
|
Increased
|
|
|
34
|
Perceptive Advisors
New York
|
$489M
|
-$10.9M
|
9
|
14.12%
|
Reduced
|
|
|
35
|
RA Capital Management
Boston,
Massachusetts
|
$487M
|
+$15.8M
|
9
|
6%
|
Increased
|
|
|
36
|
Suvretta Capital Management
New York
|
$484M
|
-$14.5M
|
9
|
12.4%
|
Reduced
|
|
|
37
|
T. Rowe Price Associates
Baltimore,
Maryland
|
$477M
|
-$651K
|
36
|
0.05%
|
Reduced
|
|
|
38
|
Millennium Management
New York
|
$424M
|
-$52.2M
|
58
|
0.18%
|
Reduced
|
|
|
39
|
EcoR1 Capital
San Francisco,
California
|
$423M
|
+$8.11M
|
7
|
20.28%
|
Increased
|
|
|
40
|
Paradigm Biocapital Advisors
New York
|
$417M
|
-$30.6M
|
2
|
11.87%
|
Reduced
|
|
|
41
|
Allspring Global Investments
Charlotte,
North Carolina
|
$415M
|
-$20.9M
|
9
|
0.67%
|
Reduced
|
|
|
42
|
Frazier Life Sciences Management
Palo Alto,
California
|
$410M
|
+$10.4M
|
8
|
12.28%
|
Increased
|
|
|
43
|
Two Sigma Investments
New York
|
$404M
|
-$66.8M
|
56
|
0.6%
|
Reduced
|
|
|
44
|
Principal Financial Group
Des Moines,
Iowa
|
$402M
|
-$197K
|
13
|
0.2%
|
Reduced
|
|
|
45
|
Capital International Investors
Los Angeles,
California
|
$397M
|
-$10.5M
|
2
|
0.06%
|
Reduced
|
|
|
46
|
Ameriprise
Minneapolis,
Minnesota
|
$380M
|
+$109M
|
23
|
0.09%
|
Increased
|
|
|
47
|
Tang Capital Management
San Diego,
California
|
$357M
|
+$57M
|
16
|
13.74%
|
Increased
|
|
|
48
|
SR One Capital Management
Wayne,
Pennsylvania
|
$337M
|
+$56.8M
|
4
|
48.71%
|
Increased
|
|
|
49
|
NEA Management Company
Timonium,
Maryland
|
$333M
|
-$84.9M
|
5
|
18.26%
|
Reduced
|
|
|
50
|
Orbis Allan Gray
Hamilton,
Bermuda
|
$323M
|
+$127M
|
1
|
1.39%
|
Increased
|
|