|
26
|
|
$678M
|
-$38.4M
|
86
|
0.05%
|
Reduced
|
|
|
27
|
RA Capital Management
Boston,
Massachusetts
|
$669M
|
+$60.3M
|
10
|
8.9%
|
Increased
|
|
|
28
|
Loomis, Sayles & Company
Boston,
Massachusetts
|
$634M
|
-$23.7M
|
3
|
0.8%
|
Reduced
|
|
|
29
|
Bank of New York Mellon
New York
|
$568M
|
-$74.4M
|
56
|
0.1%
|
Reduced
|
|
|
30
|
Citadel Advisors
Miami,
Florida
|
$547M
|
+$77.5M
|
62
|
0.09%
|
Increased
|
|
|
31
|
T. Rowe Price Investment Management
Baltimore,
Maryland
|
$538M
|
+$55.9M
|
6
|
0.33%
|
Increased
|
|
|
32
|
ARK Investment Management
St. Petersburg,
Florida
|
$514M
|
+$71.7M
|
4
|
4.28%
|
Increased
|
|
|
33
|
Farallon Capital Management
San Francisco,
California
|
$512M
|
-$372M
|
7
|
2.25%
|
Reduced
|
|
|
34
|
Perceptive Advisors
New York
|
$500M
|
-$63.9M
|
8
|
13.78%
|
Reduced
|
|
|
35
|
Charles Schwab
San Francisco,
California
|
$476M
|
-$85.1M
|
56
|
0.09%
|
Reduced
|
|
|
36
|
|
$438M
|
+$31.4M
|
9
|
29.13%
|
Increased
|
|
|
37
|
Deutsche Bank
Frankfurt Am Main Ge,
Germany
|
$389M
|
-$92.6M
|
51
|
0.15%
|
Reduced
|
|
|
38
|
Renaissance Technologies
New York
|
$389M
|
+$51.5M
|
57
|
0.58%
|
Increased
|
|
|
39
|
Suvretta Capital Management
New York
|
$388M
|
+$173M
|
9
|
13.23%
|
Increased
|
|
|
40
|
NEA Management Company
Timonium,
Maryland
|
$374M
|
+$1.96M
|
6
|
21.13%
|
Increased
|
|
|
41
|
Paradigm Biocapital Advisors
New York
|
$374M
|
+$45.1M
|
2
|
13%
|
Increased
|
|
|
42
|
Allspring Global Investments
Charlotte,
North Carolina
|
$373M
|
+$2.25M
|
10
|
0.6%
|
Increased
|
|
|
43
|
|
$364M
|
-$282M
|
17
|
0.05%
|
Reduced
|
|
|
44
|
Principal Financial Group
Des Moines,
Iowa
|
$355M
|
-$18.5M
|
15
|
0.19%
|
Reduced
|
|
|
45
|
Armistice Capital
New York
|
$353M
|
-$30.3M
|
7
|
4.82%
|
Reduced
|
|
|
46
|
Kayne Anderson Rudnick Investment Management
Los Angeles,
California
|
$334M
|
-$25.9M
|
3
|
0.77%
|
Reduced
|
|
|
47
|
EcoR1 Capital
San Francisco,
California
|
$332M
|
+$126M
|
14
|
12.54%
|
Increased
|
|
|
48
|
Wells Fargo
San Francisco,
California
|
$325M
|
-$17.5M
|
73
|
0.07%
|
Reduced
|
|
|
49
|
Frazier Life Sciences Management
Palo Alto,
California
|
$318M
|
-$28.8M
|
9
|
13.18%
|
Reduced
|
|
|
50
|
Pictet Asset Management
Carouge,
Switzerland
|
$312M
|
-$13M
|
13
|
0.34%
|
Reduced
|
|