Zymeworks
ZYME
181 hedge funds and large institutions have $949M invested in Zymeworks in 2025 Q2 according to their latest regulatory filings, with 29 funds opening new positions, 62 increasing their positions, 55 reducing their positions, and 30 closing their positions.
376% more call options, than puts
Call options by funds: $4.2M | Put options by funds: $883K
13% more capital invested
Capital invested by funds: $841M → $949M (+$108M)
13% more repeat investments, than reductions
Existing positions increased: 62 | Existing positions reduced: 55
7.23% more ownership
Funds ownership: 101.45% → 108.68% (+7.2%)
0% more funds holding in top 10
Funds holding in top 10: 5 → 5 (0)
3% less first-time investments, than exits
New positions opened: 29 | Existing positions closed: 30
2% less funds holding
Funds holding: 184 → 181 (-3)
Top Buyers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
EC
EcoR1 Capital
San Francisco,
California
|
+$68M |
| 2 |
Vanguard Group
Malvern,
Pennsylvania
|
+$8.31M |
| 3 |
VPC
Vestal Point Capital
New York
|
+$7.74M |
| 4 |
Adage Capital Partners
Boston,
Massachusetts
|
+$5.67M |
| 5 |
N
Nuveen
Charlotte,
North Carolina
|
+$5.43M |
Top Sellers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
UBS AM
Chicago,
Illinois
|
-$16.9M |
| 2 |
BCM
Bridgeway Capital Management
Houston,
Texas
|
-$9.13M |
| 3 |
RG
Redmile Group
San Francisco,
California
|
-$7.6M |
| 4 |
PA
Perceptive Advisors
New York
|
-$7.02M |
| 5 |
FCM
Farallon Capital Management
San Francisco,
California
|
-$4.76M |
| Name | Holding | Trade Value |
Shares Change |
Change in Stake |
|
|---|---|---|---|---|---|
|
SAM
201
Smartleaf Asset Management
Boston,
Massachusetts
| – | -$4.96K | -401 | Closed |
|
|
ACM
202
Aster Capital Management
Dubai,
United Arab Emirates
| – | -$2.91K | -217 | Closed |
|
|
MAM
203
Meeder Asset Management
Dublin,
Ohio
| – | -$2.45K | -206 | Closed |
|
|
PFBT
204
Parkside Financial Bank & Trust
Saint Louis,
Missouri
| – | -$1.86K | -156 | Closed |
|
|
CCM
205
Coldstream Capital Management
Bellevue,
Washington
| – | -$1.54K | -129 | Closed |
|
206
Amundi
Paris,
France
| – | -$1.25K | -106 | Closed |
|
|
SC
207
Stephens Consulting
Flint,
Michigan
| – | -$358 | -30 | Closed |
|
|
S
208
SignatureFD
Atlanta,
Georgia
| – | -$226 | -19 | Closed |
|
|
VCM
209
Versant Capital Management
Phoenix,
Arizona
| – | -$143 | -12 | Closed |
|
|
C
210
Covestor
London,
United Kingdom
| – | -$12 | -1 | -4% |
|
|
CW
211
Curio Wealth
Annapolis,
Maryland
| – | -$14.6K | -1 | Closed |
|
ZYME Hedge Fund Activity: Q2 2025 in Review
181 of the 7,596 institutional investors tracked by Wall St. Rank reported a position in Zymeworks (ZYME) for Q2 2025, worth a combined $949M — up 13% from $841M a quarter earlier.
Sellers outnumbered buyers: 30 funds closed out of ZYME and 29 opened new positions — a net loss of 1 holder — while 55 trimmed existing stakes and 62 added.
The largest buyer was EcoR1 Capital, adding an estimated $68M. The largest seller was UBS AM, cutting an estimated $16.9M.
- 181 institutional investors held Zymeworks (ZYME) as of Q2 2025, down from 184 in Q1 2025.
- Funds reported $949M of Zymeworks stock for Q2 2025, up 13% quarter-over-quarter.
- 29 funds opened new Zymeworks positions in Q2 2025 and 30 closed out, a net change of -1 holder.
- The largest Zymeworks buyer in Q2 2025 was EcoR1 Capital, an estimated $68M added.
- The largest Zymeworks seller in Q2 2025 was UBS AM, an estimated $16.9M sold.
Based on aggregated 13F filings for Q2 2025.