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Zymeworks
ZYME

181 hedge funds and large institutions have $949M invested in Zymeworks in 2025 Q2 according to their latest regulatory filings, with 29 funds opening new positions, 62 increasing their positions, 55 reducing their positions, and 30 closing their positions.

New
Increased
Maintained
Reduced
Closed

376% more call options, than puts

Call options by funds: $4.2M | Put options by funds: $883K

13% more capital invested

Capital invested by funds: $841M → $949M (+$108M)

13% more repeat investments, than reductions

Existing positions increased: 62 | Existing positions reduced: 55

7.23% more ownership

Funds ownership: 101.45% → 108.68% (+7.2%)

0% more funds holding in top 10

Funds holding in top 10: 5 → 5 (0)

3% less first-time investments, than exits

New positions opened: 29 | Existing positions closed: 30

2% less funds holding

Funds holding: 184 → 181 (-3)

Holders
181
Holders Change
-3
Holders Change %
-1.63%
% of All Funds
2.38%
Holding in Top 10
5
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.07%
New
29
Increased
62
Reduced
55
Closed
30
Calls
$4.2M
Puts
$883K
Net Calls
+$3.32M
Net Calls Change
+$154K

Top Buyers

Rank Fund Capital Flow
1
EC
EcoR1 Capital
California
+$68M
2
Vanguard Group
Vanguard Group
Pennsylvania
+$8.31M
3
VPC
Vestal Point Capital
New York
+$7.74M
4
Adage Capital Partners
Adage Capital Partners
Massachusetts
+$5.67M
5
N
Nuveen
North Carolina
+$5.43M

Top Sellers

Rank Fund Capital Flow
1
UBS AM
UBS AM
Illinois
-$16.9M
2
BCM
Bridgeway Capital Management
Texas
-$9.13M
3
RG
Redmile Group
California
-$7.6M
4
PA
Perceptive Advisors
New York
-$7.02M
5
FCM
Farallon Capital Management
California
-$4.76M
Name Holding Trade Value Shares
Change 		Change in
Stake
CA
176
CoreCap Advisors
Michigan
$226 – – –
EP
177
Essential Partners
California
$176 +$167 +14 New
Northwestern Mutual Wealth Management
178
Northwestern Mutual Wealth Management
Wisconsin
$176 +$167 +14 New
SS
179
SBI Securities
Japan
$126 – – –
TWD
180
True Wealth Design
Ohio
$88 -$155 -13 -65%
BCM
181
Bridgeway Capital Management
Texas
– -$9.13M -766,944 Closed
FCM
182
Farallon Capital Management
California
– -$4.76M -400,000 Closed
EF
183
Empowered Funds
Pennsylvania
– -$4.29M -360,044 Closed
Walleye Capital
184
Walleye Capital
New York
– -$2.95M -247,959 Closed
Verition Fund Management
185
Verition Fund Management
Connecticut
– -$1.36M -114,156 Closed
Voloridge Investment Management
186
Voloridge Investment Management
Florida
– -$1.14M -95,394 Closed
ACM
187
Aquilo Capital Management
California
– -$1.01M -84,482 Closed
ACM
188
ADAR1 Capital Management
Texas
– -$596K -50,000 Closed
HS
189
HighVista Strategies
Massachusetts
– -$496K -41,607 Closed
Franklin Resources
190
Franklin Resources
California
– -$383K -32,160 Closed
CF
191
Corebridge Financial
Texas
– -$318K -26,719 Closed
SSA
192
Schonfeld Strategic Advisors
New York
– -$261K -21,900 Closed
SFI
193
Susquehanna Fundamental Investments
Pennsylvania
– -$204K -17,090 Closed
CWM
194
CIBC World Markets
New York
– -$144K -12,102 Closed
Jacobs Levy Equity Management
195
Jacobs Levy Equity Management
New Jersey
– -$143K -12,040 Closed
OWA
196
One Wealth Advisors
California
– -$124K -10,404 Closed
ETC
197
Exchange Traded Concepts
Oklahoma
– -$121K -10,126 Closed
Lazard Asset Management
198
Lazard Asset Management
New York
– -$45K -3,787 Closed
ACM
199
Aquatic Capital Management
Illinois
– -$24.4K -2,049 Closed
WF
200
Wayfinding Financial
Washington
– -$11K -981 Closed
5 6 7
8
9

ZYME Hedge Fund Activity: Q2 2025 in Review

181 of the 7,596 institutional investors tracked by Wall St. Rank reported a position in Zymeworks (ZYME) for Q2 2025, worth a combined $949M — up 13% from $841M a quarter earlier.

Sellers outnumbered buyers: 30 funds closed out of ZYME and 29 opened new positions — a net loss of 1 holder — while 55 trimmed existing stakes and 62 added.

The largest buyer was EcoR1 Capital, adding an estimated $68M. The largest seller was UBS AM, cutting an estimated $16.9M.

  • 181 institutional investors held Zymeworks (ZYME) as of Q2 2025, down from 184 in Q1 2025.
  • Funds reported $949M of Zymeworks stock for Q2 2025, up 13% quarter-over-quarter.
  • 29 funds opened new Zymeworks positions in Q2 2025 and 30 closed out, a net change of -1 holder.
  • The largest Zymeworks buyer in Q2 2025 was EcoR1 Capital, an estimated $68M added.
  • The largest Zymeworks seller in Q2 2025 was UBS AM, an estimated $16.9M sold.

Based on aggregated 13F filings for Q2 2025.