We are live on ! Find out more
ZYME icon

Zymeworks
ZYME

181 hedge funds and large institutions have $949M invested in Zymeworks in 2025 Q2 according to their latest regulatory filings, with 29 funds opening new positions, 62 increasing their positions, 55 reducing their positions, and 30 closing their positions.

New
Increased
Maintained
Reduced
Closed

376% more call options, than puts

Call options by funds: $4.2M | Put options by funds: $883K

13% more capital invested

Capital invested by funds: $841M → $949M (+$108M)

13% more repeat investments, than reductions

Existing positions increased: 62 | Existing positions reduced: 55

7.23% more ownership

Funds ownership: 101.45% → 108.68% (+7.2%)

0% more funds holding in top 10

Funds holding in top 10: 5 → 5 (0)

3% less first-time investments, than exits

New positions opened: 29 | Existing positions closed: 30

2% less funds holding

Funds holding: 184 → 181 (-3)

Holders
181
Holders Change
-3
Holders Change %
-1.63%
% of All Funds
2.38%
Holding in Top 10
5
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.07%
New
29
Increased
62
Reduced
55
Closed
30
Calls
$4.2M
Puts
$883K
Net Calls
+$3.32M
Net Calls Change
+$154K

Top Buyers

Rank Fund Capital Flow
1
EC
EcoR1 Capital
California
+$68M
2
Vanguard Group
Vanguard Group
Pennsylvania
+$8.31M
3
VPC
Vestal Point Capital
New York
+$7.74M
4
Adage Capital Partners
Adage Capital Partners
Massachusetts
+$5.67M
5
N
Nuveen
North Carolina
+$5.43M

Top Sellers

Rank Fund Capital Flow
1
UBS AM
UBS AM
Illinois
-$16.9M
2
BCM
Bridgeway Capital Management
Texas
-$9.13M
3
RG
Redmile Group
California
-$7.6M
4
PA
Perceptive Advisors
New York
-$7.02M
5
FCM
Farallon Capital Management
California
-$4.76M
Name Holding Trade Value Shares
Change 		Change in
Stake
Osaic Holdings
151
Osaic Holdings
Arizona
$8.38K +$3.15K +264 +65%
CIAM
152
Caitong International Asset Management
Hong Kong
$7.08K +$6.72K +564 New
National Bank of Canada
153
National Bank of Canada
Quebec, Canada
$5.92K -$619 -52 -10%
PNC Financial Services Group
154
PNC Financial Services Group
Pennsylvania
$4.24K +$1.29K +108 +47%
PA
155
Parallel Advisors
California
$4.13K – – –
Daiwa Securities Group
156
Daiwa Securities Group
Japan
$4K – – –
TC
157
Truvestments Capital
Florida
$3.88K – – –
TWC
158
TD Waterhouse Canada
Ontario, Canada
$3.85K – – –
HWM
159
HighMark Wealth Management
Minnesota
$3.51K – – –
US Bancorp
160
US Bancorp
Minnesota
$3.11K -$2.08K -175 -41%
EWA
161
EverSource Wealth Advisors
Alabama
$2.27K +$2K +168 +1,292%
AF
162
Allworth Financial
California
$1.53K +$143 +12 +11%
SCM
163
Sterling Capital Management
North Carolina
$1.49K -$9.79K -822 -87%
BIG
164
Brooklyn Investment Group
New York
$1.39K -$2.12K -178 -62%
Group One Trading
165
Group One Trading
Illinois
$1.25K – – –
IA
166
IFP Advisors
Florida
$1.21K +$1.14K +96 New
PD
167
Point72 (DIFC)
United Arab Emirates
$966 +$917 +77 New
KG
168
Kilter Group
New York
$829 +$786 +66 New
RIL
169
Rothschild Investment LLC
Illinois
$690 -$536 -45 -45%
SPIA
170
Steward Partners Investment Advisory
New York
$665 – – –
PWA
171
Physician Wealth Advisors
Utah
$641 +$608 +51 New
BFS
172
Bare Financial Services
Pennsylvania
$565 +$536 +45 New
CPG
173
Cornerstone Planning Group
New Jersey
$439 +$417 +35 New
FFA
174
Farther Finance Advisors
California
$314 -$1.36K -114 -82%
AG
175
AmeriFlex Group
Nevada
$247 – – –
5 6
7
8 9

ZYME Hedge Fund Activity: Q2 2025 in Review

181 of the 7,596 institutional investors tracked by Wall St. Rank reported a position in Zymeworks (ZYME) for Q2 2025, worth a combined $949M — up 13% from $841M a quarter earlier.

Sellers outnumbered buyers: 30 funds closed out of ZYME and 29 opened new positions — a net loss of 1 holder — while 55 trimmed existing stakes and 62 added.

The largest buyer was EcoR1 Capital, adding an estimated $68M. The largest seller was UBS AM, cutting an estimated $16.9M.

  • 181 institutional investors held Zymeworks (ZYME) as of Q2 2025, down from 184 in Q1 2025.
  • Funds reported $949M of Zymeworks stock for Q2 2025, up 13% quarter-over-quarter.
  • 29 funds opened new Zymeworks positions in Q2 2025 and 30 closed out, a net change of -1 holder.
  • The largest Zymeworks buyer in Q2 2025 was EcoR1 Capital, an estimated $68M added.
  • The largest Zymeworks seller in Q2 2025 was UBS AM, an estimated $16.9M sold.

Based on aggregated 13F filings for Q2 2025.