Zymeworks
ZYME
209 hedge funds and large institutions have $1.88B invested in Zymeworks in 2025 Q4 according to their latest regulatory filings, with 47 funds opening new positions, 71 increasing their positions, 62 reducing their positions, and 19 closing their positions.
158% more call options, than puts
Call options by funds: $15.2M | Put options by funds: $5.9M
147% more first-time investments, than exits
New positions opened: 47 | Existing positions closed: 19
49% more capital invested
Capital invested by funds: $1.26B → $1.88B (+$623M)
33% more funds holding in top 10
Funds holding in top 10: 3 → 4 (+1)
15% more repeat investments, than reductions
Existing positions increased: 71 | Existing positions reduced: 62
14% more funds holding
Funds holding: 183 → 209 (+26)
2.56% less ownership
Funds ownership: 98.05% → 95.49% (-2.6%)
Top Buyers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
BNP Paribas Asset Management
Paris,
France
|
+$39.7M |
| 2 |
SL
Siren LLC
Greenwich,
Connecticut
|
+$36.6M |
| 3 |
PA
Perceptive Advisors
New York
|
+$25.5M |
| 4 |
RCMNY
Rubric Capital Management (New York)
New York
|
+$22.7M |
| 5 |
CFM
Capricorn Fund Managers
London,
United Kingdom
|
+$22.3M |
Top Sellers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
RG
Redmile Group
San Francisco,
California
|
-$70.1M |
| 2 |
Morgan Stanley
New York
|
-$30.4M |
| 3 |
UBS AM
Chicago,
Illinois
|
-$30.3M |
| 4 |
Blackstone Inc
New York
|
-$27.6M |
| 5 |
TCM
Tang Capital Management
San Diego,
California
|
-$23.2M |
ZYME Hedge Fund Activity: Q4 2025 in Review
209 of the 8,228 institutional investors tracked by Wall St. Rank reported a position in Zymeworks (ZYME) for Q4 2025, worth a combined $1.88B — up 49% from $1.26B a quarter earlier.
Buyers outnumbered sellers: 47 funds opened new ZYME positions and 19 closed out — a net gain of 28 holders — while 71 added to existing stakes and 62 trimmed.
The largest buyer was BNP Paribas Asset Management, opening a new position worth an estimated $39.7M. The largest seller was Redmile Group, cutting an estimated $70.1M.
- 209 institutional investors held Zymeworks (ZYME) as of Q4 2025, up from 183 in Q3 2025.
- Funds reported $1.88B of Zymeworks stock for Q4 2025, up 49% quarter-over-quarter.
- 47 funds opened new Zymeworks positions in Q4 2025 and 19 closed out, a net change of +28 holders.
- The largest Zymeworks buyer in Q4 2025 was BNP Paribas Asset Management, an estimated $39.7M added.
- The largest Zymeworks seller in Q4 2025 was Redmile Group, an estimated $70.1M sold.
Based on aggregated 13F filings for Q4 2025.