We are live on ! Find out more
ZYME icon

Zymeworks
ZYME

181 hedge funds and large institutions have $949M invested in Zymeworks in 2025 Q2 according to their latest regulatory filings, with 29 funds opening new positions, 62 increasing their positions, 55 reducing their positions, and 30 closing their positions.

New
Increased
Maintained
Reduced
Closed

376% more call options, than puts

Call options by funds: $4.2M | Put options by funds: $883K

13% more capital invested

Capital invested by funds: $841M → $949M (+$108M)

13% more repeat investments, than reductions

Existing positions increased: 62 | Existing positions reduced: 55

7.23% more ownership

Funds ownership: 101.45% → 108.68% (+7.2%)

0% more funds holding in top 10

Funds holding in top 10: 5 → 5 (0)

3% less first-time investments, than exits

New positions opened: 29 | Existing positions closed: 30

2% less funds holding

Funds holding: 184 → 181 (-3)

Holders
181
Holders Change
-3
Holders Change %
-1.63%
% of All Funds
2.38%
Holding in Top 10
5
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.07%
New
29
Increased
62
Reduced
55
Closed
30
Calls
$4.2M
Puts
$883K
Net Calls
+$3.32M
Net Calls Change
+$154K

Top Buyers

Rank Fund Capital Flow
1
EC
EcoR1 Capital
California
+$68M
2
Vanguard Group
Vanguard Group
Pennsylvania
+$8.31M
3
VPC
Vestal Point Capital
New York
+$7.74M
4
Adage Capital Partners
Adage Capital Partners
Massachusetts
+$5.67M
5
N
Nuveen
North Carolina
+$5.43M

Top Sellers

Rank Fund Capital Flow
1
UBS AM
UBS AM
Illinois
-$16.9M
2
BCM
Bridgeway Capital Management
Texas
-$9.13M
3
RG
Redmile Group
California
-$7.6M
4
PA
Perceptive Advisors
New York
-$7.02M
5
FCM
Farallon Capital Management
California
-$4.76M
Name Holding Trade Value Shares
Change 		Change in
Stake
Bank of New York Mellon
51
Bank of New York Mellon
New York
$1.67M +$147K +12,363 +10%
Raymond James Financial
52
Raymond James Financial
Florida
$1.56M +$92K +7,724 +7%
Charles Schwab
53
Charles Schwab
California
$1.56M -$112K -9,435 -7%
Barclays
54
Barclays
United Kingdom
$1.54M +$565K +47,390 +63%
CSS
55
Cubist Systematic Strategies
Connecticut
$1.51M +$1.43M +119,962 New
AG
56
Algert Global
California
$1.48M +$1.41M +118,104 New
Millennium Management
57
Millennium Management
New York
$1.46M -$2.14M -179,504 -61%
DFCM
58
Dark Forest Capital Management
Puerto Rico
$1.22M -$105K -8,840 -8%
NGM
59
North Growth Management
British Columbia, Canada
$1.22M – – –
Bank of America
60
Bank of America
North Carolina
$1.13M +$336K +28,247 +45%
Invesco
61
Invesco
Georgia
$1.12M +$133K +11,165 +14%
RhumbLine Advisers
62
RhumbLine Advisers
Massachusetts
$1.08M +$39.8K +3,345 +4%
SPS
63
Susquehanna Portfolio Strategies
Pennsylvania
$1.08M +$1.02M +85,728 New
ACP
64
Acuta Capital Partners
California
$1.05M +$181K +15,196 +22%
Swiss National Bank
65
Swiss National Bank
Switzerland
$917K -$83.4K -7,000 -9%
Royal Bank of Canada
66
Royal Bank of Canada
Ontario, Canada
$915K +$193K +16,212 +29%
Fisher Asset Management
67
Fisher Asset Management
Washington
$903K +$60 +5 +0%
Qube Research & Technologies (QRT)
68
Qube Research & Technologies (QRT)
United Kingdom
$877K +$832K +69,874 New
Stifel Financial
69
Stifel Financial
Missouri
$875K +$32.2K +2,700 +4%
WAM
70
Weiss Asset Management
Massachusetts
$680K +$645K +54,171 New
VRS
71
Virginia Retirement Systems
Virginia
$679K +$118K +9,900 +22%
NIM
72
NEOS Investment Management
Connecticut
$651K +$225K +18,854 +57%
TE
73
Tema ETFs
New York
$651K +$225K +18,854 +57%
ECM
74
ExodusPoint Capital Management
New York
$648K -$973K -81,651 -61%
AllianceBernstein
75
AllianceBernstein
Tennessee
$628K – – –
1 2
3
4 5

ZYME Hedge Fund Activity: Q2 2025 in Review

181 of the 7,596 institutional investors tracked by Wall St. Rank reported a position in Zymeworks (ZYME) for Q2 2025, worth a combined $949M — up 13% from $841M a quarter earlier.

Sellers outnumbered buyers: 30 funds closed out of ZYME and 29 opened new positions — a net loss of 1 holder — while 55 trimmed existing stakes and 62 added.

The largest buyer was EcoR1 Capital, adding an estimated $68M. The largest seller was UBS AM, cutting an estimated $16.9M.

  • 181 institutional investors held Zymeworks (ZYME) as of Q2 2025, down from 184 in Q1 2025.
  • Funds reported $949M of Zymeworks stock for Q2 2025, up 13% quarter-over-quarter.
  • 29 funds opened new Zymeworks positions in Q2 2025 and 30 closed out, a net change of -1 holder.
  • The largest Zymeworks buyer in Q2 2025 was EcoR1 Capital, an estimated $68M added.
  • The largest Zymeworks seller in Q2 2025 was UBS AM, an estimated $16.9M sold.

Based on aggregated 13F filings for Q2 2025.