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Zentalis Pharmaceuticals

117 hedge funds and large institutions have $64.5M invested in Zentalis Pharmaceuticals in 2025 Q2 according to their latest regulatory filings, with 22 funds opening new positions, 34 increasing their positions, 44 reducing their positions, and 37 closing their positions.

New
Increased
Maintained
Reduced
Closed

0% more funds holding in top 10

Funds holding in top 10: 22 (0)

4.12% less ownership

Funds ownership: 81.4%77.28% (-4.1%)

11% less funds holding

Funds holding: 132117 (-15)

23% less repeat investments, than reductions

Existing positions increased: 34 | Existing positions reduced: 44

31% less capital invested

Capital invested by funds: $92.9M → $64.5M (-$28.4M)

41% less first-time investments, than exits

New positions opened: 22 | Existing positions closed: 37

100% less call options, than puts

Call options by funds: $0 | Put options by funds: $73K

Holders
117
Holders Change
-15
Holders Change %
-11.36%
% of All Funds
1.54%
Holding in Top 10
2
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
0.03%
New
22
Increased
34
Reduced
44
Closed
37
Calls
Puts
$73K
Net Calls
-$73K
Net Calls Change
+$84K
Name Holding Trade Value Shares
Change
Change in
Stake
MCMC
1
Matrix Capital Management Company
New Hampshire
$16.2M
Millennium Management
2
Millennium Management
New York
$4.03M +$537K +407,294 +13%
Vanguard Group
3
Vanguard Group
Pennsylvania
$3.35M -$496K -375,980 -12%
Acadian Asset Management
4
Acadian Asset Management
Massachusetts
$3.24M +$165K +124,985 +5%
OM
5
Opaleye Management
Massachusetts
$2.23M -$80.1K -60,700 -3%
BlackRock
6
BlackRock
New York
$2.02M -$3.28M -2,487,750 -59%
AC
7
Almitas Capital
California
$1.86M -$147K -111,655 -7%
TCM
8
Tang Capital Management
California
$1.8M +$65.9K +50,000 +3%
Renaissance Technologies
9
Renaissance Technologies
New York
$1.77M +$928K +703,512 +85%
TCM
10
Tybourne Capital Management
Hong Kong
$1.71M +$681K +516,666 +54%
DC
11
Decheng Capital
California
$1.54M -$919K -696,435 -34%
Two Sigma Advisers
12
Two Sigma Advisers
New York
$1.48M +$571K +433,314 +51%
D.E. Shaw & Co
13
D.E. Shaw & Co
New York
$1.39M +$105K +79,847 +7%
GCP
14
GSA Capital Partners
United Kingdom
$1.31M +$780K +591,400 +109%
Morgan Stanley
15
Morgan Stanley
New York
$1.27M +$4.87K +3,693 +0.3%
Two Sigma Investments
16
Two Sigma Investments
New York
$1.27M +$717K +543,719 +99%
Primecap Management
17
Primecap Management
California
$1.19M -$313K -237,000 -19%
Balyasny Asset Management
18
Balyasny Asset Management
Illinois
$1.13M +$1.28M +970,862 New
P
19
Pfizer
New York
$1.11M
Goldman Sachs
20
Goldman Sachs
New York
$1,000K +$535K +405,374 +89%
Jacobs Levy Equity Management
21
Jacobs Levy Equity Management
New Jersey
$995K +$671K +508,617 +146%
Bank of America
22
Bank of America
North Carolina
$827K -$550K -416,777 -37%
Jane Street
23
Jane Street
New York
$770K +$680K +515,257 +346%
Geode Capital Management
24
Geode Capital Management
Massachusetts
$717K -$973K -737,502 -54%
PLC
25
Peapod Lane Capital
New York
$649K +$1.05K +795 +0.1%

ZNTL Hedge Fund Activity: Q2 2025 in Review

117 of the 7,596 institutional investors tracked by Wall St. Rank reported a position in Zentalis Pharmaceuticals (ZNTL) for Q2 2025, worth a combined $64.5M — down 31% from $92.9M a quarter earlier.

Sellers outnumbered buyers: 37 funds closed out of ZNTL and 22 opened new positions — a net loss of 15 holders — while 44 trimmed existing stakes and 34 added.

The largest buyer was Balyasny Asset Management, opening a new position worth an estimated $1.28M. The largest seller was BlackRock, cutting an estimated $3.28M.

  • 117 institutional investors held Zentalis Pharmaceuticals (ZNTL) as of Q2 2025, down from 132 in Q1 2025.
  • Funds reported $64.5M of Zentalis Pharmaceuticals stock for Q2 2025, down 31% quarter-over-quarter.
  • 22 funds opened new Zentalis Pharmaceuticals positions in Q2 2025 and 37 closed out, a net change of -15 holders.
  • The largest Zentalis Pharmaceuticals buyer in Q2 2025 was Balyasny Asset Management, an estimated $1.28M added.
  • The largest Zentalis Pharmaceuticals seller in Q2 2025 was BlackRock, an estimated $3.28M sold.

Based on aggregated 13F filings for Q2 2025.