Two Sigma Investments
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Two Sigma Investments’s Zentalis Pharmaceuticals ZNTL Stock Holding History

Two Sigma Investments’s Portfolio ZNTL Stock Details ZNTL Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		$6.92M Buy
2,956,526
+1,485,112
+101% +$3.84M 0.01% 1706
2025
Q4 		$1.99M Buy
1,471,414
+108,067
+8% +$157K ﹤0.01% 2437
2025
Q3 		$2.06M Buy
1,363,347
+270,294
+25% +$405K ﹤0.01% 2106
2025
Q2 		$1.27M Buy
1,093,053
+543,719
+99% +$717K ﹤0.01% 2115
2025
Q1 		$873K Sell
549,334
-67,466
-11% -$145K ﹤0.01% 2252
2024
Q4 		$1.87M Sell
616,800
-291,801
-32% -$956K ﹤0.01% 1767
2024
Q3 		$3.34M Sell
908,601
-143,797
-14% -$523K 0.01% 1322
2024
Q2 		$4.3M Buy
1,052,398
+807,403
+330% +$9.02M 0.01% 1076
2024
Q1 		$3.86M Buy
+244,995
New +$3.37M 0.01% 1108
2023
Q4 		– Sell
-109,429
Closed -$2.2M – 3425
2023
Q3 		$2.2M Buy
109,429
+92,729
+555% +$2.35M 0.01% 1319
2023
Q2 		$471K Buy
+16,700
New +$401K ﹤0.01% 2359
2022
Q2 		– Sell
-94,502
Closed -$4.36M – 3001
2022
Q1 		$4.36M Buy
94,502
+80,349
+568% +$4.33M 0.01% 983
2021
Q4 		$1.19M Sell
14,153
-144,823
-91% -$11.2M ﹤0.01% 2394
2021
Q3 		$10.6M Buy
158,976
+30,105
+23% +$1.74M 0.02% 753
2021
Q2 		$6.86M Buy
+128,871
New +$6.9M 0.02% 1005
2021
Q1 		– Sell
-57,031
Closed -$2.96M – 4318
2020
Q4 		$2.96M Buy
+57,031
New +$2.57M 0.01% 1244

Other funds holding ZNTL

5VM
5AM Venture Management San Francisco, California $360M AUM 345.76% 1-Year Est. Return
SCM
Squadron Capital Management Westmont, Illinois $273M AUM
Acadian Asset Management
Acadian Asset Management Boston, Massachusetts $70.5B AUM 36% 1-Year Est. Return
VCM
Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM
Renaissance Technologies
Renaissance Technologies New York $63.9B AUM 45.56% 1-Year Est. Return
Citadel Advisors
Citadel Advisors Miami, Florida $618B AUM 30.34% 1-Year Est. Return
D.E. Shaw & Co
D.E. Shaw & Co New York $166B AUM 43.98% 1-Year Est. Return
OM
Opaleye Management Boston, Massachusetts $759M AUM 124.8% 1-Year Est. Return
DC
Decheng Capital Menlo Park, California $661M AUM 299.97% 1-Year Est. Return
Millennium Management
Millennium Management New York $240B AUM 35.51% 1-Year Est. Return

Two Sigma Investments's ZNTL Position: Q1 2026 in Review

Two Sigma Investments increased its Zentalis Pharmaceuticals (ZNTL) stake by 101% in Q1 2026, buying an estimated $3.84M and bringing the position to 2,956,526 shares worth $6.92M. The position accounts for 0.01% of the portfolio, ranked #1706.

Two Sigma Investments first reported a position in ZNTL in Q4 2020 and has held it in 16 quarters since. The position peaked at $10.6M in Q3 2021. 102 funds tracked by Wall St. Rank hold ZNTL as of Q1 2026.

  • Two Sigma Investments held 2,956,526 shares of Zentalis Pharmaceuticals worth $6.92M as of Q1 2026.
  • Two Sigma Investments bought 1,485,112 Zentalis Pharmaceuticals shares in Q1 2026, an estimated $3.84M.
  • Zentalis Pharmaceuticals made up 0.01% of Two Sigma Investments's portfolio in Q1 2026, its #1706 holding.
  • Two Sigma Investments first reported a position in Zentalis Pharmaceuticals in Q4 2020 and has held it in 16 quarters since.
  • Two Sigma Investments's Zentalis Pharmaceuticals position peaked at $10.6M in Q3 2021.
  • 102 funds tracked by Wall St. Rank held Zentalis Pharmaceuticals as of Q1 2026.

Based on Two Sigma Investments's 13F filing for Q1 2026, filed 15 May 2026.