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X4 Pharmaceuticals
XFOR

84 hedge funds and large institutions have $388M invested in X4 Pharmaceuticals in 2026 Q1 according to their latest regulatory filings, with 18 funds opening new positions, 22 increasing their positions, 23 reducing their positions, and 11 closing their positions.

New
Increased
Maintained
Reduced
Closed

64% more first-time investments, than exits

New positions opened: 18 | Existing positions closed: 11

50% more funds holding in top 10

Funds holding in top 10: 4 → 6 (+2)

8% more capital invested

Capital invested by funds: $358M → $388M (+$30.4M)

6% more funds holding

Funds holding: 79 → 84 (+5)

1.01% more ownership

Funds ownership: 102.28% → 103.28% (+1%)

4% less repeat investments, than reductions

Existing positions increased: 22 | Existing positions reduced: 23

Holders
84
Holders Change
+5
Holders Change %
+6.33%
% of All Funds
1.03%
Holding in Top 10
6
Holding in Top 10 Change
+2
Holding in Top 10 Change %
+50%
% of All Funds
0.07%
New
18
Increased
22
Reduced
23
Closed
11
Calls
–
Puts
–
Net Calls
–
Net Calls Change
–

Top Buyers

1
DTC
Deep Track Capital
Connecticut
+$4.97M
2
Morgan Stanley
Morgan Stanley
New York
+$4.72M
3
Millennium Management
Millennium Management
New York
+$4.32M
4
Susquehanna International Group
Susquehanna International Group
Pennsylvania
+$3.12M
5
SVCM
Saturn V Capital Management
Texas
+$2.46M

Top Sellers

1
SL
Siren LLC
Connecticut
-$6M
2
Point72 Asset Management
Point72 Asset Management
Connecticut
-$3.23M
3
Fidelity Investments
Fidelity Investments
Massachusetts
-$1.48M
4
SCM
Silverarc Capital Management
Massachusetts
-$1.43M
5
SCM
Stonepine Capital Management
Oregon
-$967K
Name Holding Trade Value Shares
Change 		Change in
Stake
Morgan Stanley
1
Morgan Stanley
New York
$39.1M +$4.72M +1,258,977 +15%
EAM
2
Empery Asset Management
New York
$36.9M -$26.2K -6,987 -0.1%
Fidelity Investments
3
Fidelity Investments
Massachusetts
$33.5M -$1.48M -395,700 -5%
BCLSI
4
Bain Capital Life Sciences Investors
Massachusetts
$32.9M – – –
PA
5
Perceptive Advisors
New York
$27.8M +$1.59M +423,196 +7%
SVCM
6
Saturn V Capital Management
Texas
$26.7M +$2.46M +656,116 +11%
DTC
7
Deep Track Capital
Connecticut
$26.2M +$4.97M +1,325,874 +26%
KCM
8
Kalehua Capital Management
Texas
$15.4M – – –
VCM
9
Vanguard Capital Management
Pennsylvania
$14.4M +$13.1M +3,497,612 New
B
10
Braidwell
Connecticut
$13.5M -$359K -95,950 -3%
NMC
11
NEA Management Company
Maryland
$13.4M – – –
RA
12
Rosalind Advisors
Ontario, Canada
$13.3M +$2.28M +608,846 +23%
Blackstone Inc
13
Blackstone Inc
New York
$11.1M – – –
TECP
14
Trails Edge Capital Partners
Georgia
$10.6M – – –
NCM
15
Nantahala Capital Management
Connecticut
$10.1M – – –
BI
16
BVF Inc
California
$9.23M – – –
SB
17
Samsara BioCapital
California
$7.57M -$477K -127,434 -7%
BlackRock
18
BlackRock
New York
$5M -$56.2K -15,014 -1%
Millennium Management
19
Millennium Management
New York
$5M +$4.32M +1,154,536 +2,062%
WP
20
Woodline Partners
California
$4.13M +$899 +240 +0%
Geode Capital Management
21
Geode Capital Management
Massachusetts
$3.88M -$2.7K -721 -0.1%
Goldman Sachs
22
Goldman Sachs
New York
$3.64M +$188K +50,244 +6%
Susquehanna International Group
23
Susquehanna International Group
Pennsylvania
$3.54M +$3.12M +834,087 +3,768%
SC
24
Stempoint Capital
New York
$3.51M -$179K -47,723 -5%
VFT
25
Vanguard Fiduciary Trust
Pennsylvania
$1.99M +$1.8M +480,733 New
1
2 3 4

XFOR Hedge Fund Activity: Q1 2026 in Review

84 of the 8,126 institutional investors tracked by Wall St. Rank reported a position in X4 Pharmaceuticals (XFOR) for Q1 2026, worth a combined $388M — up 8.5% from $358M a quarter earlier.

Buyers outnumbered sellers: 18 funds opened new XFOR positions and 11 closed out — a net gain of 7 holders — while 22 added to existing stakes and 23 trimmed.

The largest buyer was Deep Track Capital, adding an estimated $4.97M. The largest seller was Siren LLC, exiting entirely with an estimated $6M sold.

  • 84 institutional investors held X4 Pharmaceuticals (XFOR) as of Q1 2026, up from 79 in Q4 2025.
  • Funds reported $388M of X4 Pharmaceuticals stock for Q1 2026, up 8.5% quarter-over-quarter.
  • 18 funds opened new X4 Pharmaceuticals positions in Q1 2026 and 11 closed out, a net change of +7 holders.
  • The largest X4 Pharmaceuticals buyer in Q1 2026 was Deep Track Capital, an estimated $4.97M added.
  • The largest X4 Pharmaceuticals seller in Q1 2026 was Siren LLC, an estimated $6M sold.

Based on aggregated 13F filings for Q1 2026.