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Xenon Pharmaceuticals
XENE

Overview Fund Activity

205 hedge funds and large institutions have $2.6B invested in Xenon Pharmaceuticals in 2025 Q2 according to their latest regulatory filings, with 41 funds opening new positions, 77 increasing their positions, 55 reducing their positions, and 40 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
205
Holders Change
-1
Holders Change %
-0.49%
% of All Funds
2.75%
Holding in Top 10
10
Holding in Top 10 Change
-4
Holding in Top 10 Change %
-28.57%
% of All Funds
0.13%
New
41
Increased
77
Reduced
55
Closed
40
Calls
$11.4M
Puts
$9.75M
Net Calls
+$1.67M
Net Calls Change
-$6.22M

Top Buyers

1
BlackRock
1
BlackRock
New York
$168M
2
Holocene Advisors
2
Holocene Advisors
New York
$56.6M
3
State Street
3
State Street
Massachusetts
$43.2M
4
Geode Capital Management
4
Geode Capital Management
Massachusetts
$30.4M
5
B
5
Braidwell
Connecticut
$113M

Top Sellers

1
Wellington Management Group
1
Wellington Management Group
Massachusetts
$68.1M
2
Capital World Investors
2
Capital World Investors
California
$20.5M
3
SC
3
Samlyn Capital
New York
$0
4
T. Rowe Price Investment Management
4
T. Rowe Price Investment Management
Maryland
$2.41M
5
LGM
5
Logos Global Management
California
$0
Name Holding Trade Value Shares
Change 		Shares
Change %
JSAM
201
J. Safra Asset Management
New York
$454 +$97 +3 +27%
GI
202
GAMMA Investing
California
$438 +$188 +6 +75%
BIA
203
Bell Investment Advisors
California
$345 – – –
ANBT
204
American National Bank & Trust
Texas
$157 +$157 +5 New
TPWA
205
Twin Peaks Wealth Advisors
California
$36 +$36 +1 New
SC
206
Samlyn Capital
New York
– -$34.1M -1,016,381 Closed
LGM
207
Logos Global Management
California
– -$21.8M -650,000 Closed
BCM
208
Boxer Capital Management
California
– -$20.1M -600,000 Closed
Alyeska Investment Group
209
Alyeska Investment Group
Illinois
– -$12.3M -367,233 Closed
SC
210
Stempoint Capital
New York
– -$9.21M -274,633 Closed
Two Sigma Investments
211
Two Sigma Investments
New York
– -$7.95M -236,983 Closed
Point72 Asset Management
212
Point72 Asset Management
Connecticut
– -$7.04M -209,759 Closed
NFGH
213
Nan Fung Group Holdings
Hong Kong
– -$5.32M -158,605 Closed
BM
214
Bridger Management
New York
– -$4.93M -146,800 Closed
PHS
215
PFM Health Sciences
California
– -$3.09M -92,236 Closed
Lord, Abbett & Co
216
Lord, Abbett & Co
New Jersey
– -$2.95M -87,981 Closed
ABG
217
Ally Bridge Group
New York
– -$2.34M -69,603 Closed
ACM
218
Altium Capital Management
New York
– -$2.02M -60,251 Closed
ECM
219
ExodusPoint Capital Management
New York
– -$1.41M -42,000 Closed
AI
220
Allostery Investments
Connecticut
– -$1.01M -30,000 Closed
SFM
221
Sphera Funds Management
Israel
– -$876K -26,097 Closed
ACM
222
Atika Capital Management
New York
– -$805K -24,000 Closed
SMH
223
Sanders Morris Harris
Texas
– -$659K -21,500 Closed
PCM
224
Prelude Capital Management
New York
– -$613K -18,266 Closed
BC
225
BIT Capital
Germany
– -$582K -17,352 Closed
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9
10