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Xenon Pharmaceuticals

246 hedge funds and large institutions have $3.78B invested in Xenon Pharmaceuticals in 2025 Q4 according to their latest regulatory filings, with 51 funds opening new positions, 81 increasing their positions, 74 reducing their positions, and 22 closing their positions.

New
Increased
Maintained
Reduced
Closed

132% more first-time investments, than exits

New positions opened: 51 | Existing positions closed: 22

12% more funds holding

Funds holding: 219246 (+27)

12% more capital invested

Capital invested by funds: $3.39B → $3.78B (+$399M)

9% more repeat investments, than reductions

Existing positions increased: 81 | Existing positions reduced: 74

0% more funds holding in top 10

Funds holding in top 10: 99 (0)

0.06% less ownership

Funds ownership: 109.36%109.29% (-0.06%)

34% less call options, than puts

Call options by funds: $36.4M | Put options by funds: $54.7M

Holders
246
Holders Change
+27
Holders Change %
+12.33%
% of All Funds
2.99%
Holding in Top 10
9
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
0.11%
New
51
Increased
81
Reduced
74
Closed
22
Calls
$36.4M
Puts
$54.7M
Net Calls
-$18.4M
Net Calls Change
-$14.5M
Name Holding Trade Value Shares
Change
Change in
Stake
Aberdeen Group
26
Aberdeen Group
United Kingdom
$33.6M +$7.19M +171,146 +30%
Goldman Sachs
27
Goldman Sachs
New York
$31.2M -$1.03M -24,612 -3%
Fiera Capital (Canada)
28
Fiera Capital (Canada)
Quebec, Canada
$30.7M +$6.97M +166,057 +32%
Adage Capital Partners
29
Adage Capital Partners
Massachusetts
$30.7M -$6.3M -150,000 -18%
American Century Companies
30
American Century Companies
Missouri
$30.5M +$891K +21,216 +3%
Federated Hermes
31
Federated Hermes
Pennsylvania
$30.1M +$18.5M +439,737 +189%
Vanguard Group
32
Vanguard Group
Pennsylvania
$29.8M -$7.84M -186,745 -22%
Capital World Investors
33
Capital World Investors
California
$29.4M
Millennium Management
34
Millennium Management
New York
$28.5M -$31.5M -748,951 -54%
Pictet Asset Management
35
Pictet Asset Management
Switzerland
$28M -$26.7M -636,594 -50%
Loomis, Sayles & Company
36
Loomis, Sayles & Company
Massachusetts
$27.4M -$1.2M -28,594 -4%
Barclays
37
Barclays
United Kingdom
$26.9M +$20.6M +489,664 +440%
VPC
38
Vestal Point Capital
New York
$26.9M -$21M -500,000 -45%
TECP
39
Trails Edge Capital Partners
Georgia
$26.8M +$25.1M +597,092 New
CP
40
Caligan Partners
New York
$24.6M +$4.41M +105,100 +24%
T. Rowe Price Investment Management
41
T. Rowe Price Investment Management
Maryland
$24.5M -$2.16M -51,500 -9%
DM
42
Deerfield Management
New York
$24.3M
TCM
43
TimesSquare Capital Management
New York
$23.9M -$1.01M -24,060 -4%
MB
44
MPM BioImpact
Massachusetts
$21.8M -$747K -17,778 -4%
Dimensional Fund Advisors
45
Dimensional Fund Advisors
Texas
$20.3M -$78.8K -1,876 -0.4%
O
46
OrbiMed
New York
$20M +$1.16M +27,600 +7%
Northern Trust
47
Northern Trust
Illinois
$19.7M -$2.5M -59,433 -12%
Two Sigma Investments
48
Two Sigma Investments
New York
$19.6M +$18.3M +436,743 New
CS
49
Candriam SCA
Luxembourg
$18.7M +$872K +20,766 +5%
Bank of New York Mellon
50
Bank of New York Mellon
New York
$17.4M -$1.31M -31,258 -7%