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Vertex Pharmaceuticals

Name Holding Trade Value Shares
Change
Change in
Stake
Parnassus Investments
26
Parnassus Investments
California
$646M -$26.3M -63,007 -4%
Deutsche Bank
27
Deutsche Bank
Germany
$627M +$80.6M +192,822 +14%
Bank of New York Mellon
28
Bank of New York Mellon
New York
$615M -$13.1M -31,308 -2%
Edgewood Management
29
Edgewood Management
Connecticut
$583M -$404M -967,405 -39%
Goldman Sachs
30
Goldman Sachs
New York
$581M -$187M -447,102 -23%
DZ Bank
31
DZ Bank
Germany
$525M +$56.7M +135,674 +11%
Royal Bank of Canada
32
Royal Bank of Canada
Ontario, Canada
$468M -$79.7M -190,659 -14%
WCM Investment Management
33
WCM Investment Management
California
$455M -$5.66M -13,538 -1%
Amundi
34
Amundi
France
$451M -$5.96M -14,255 -1%
Nuveen
35
Nuveen
North Carolina
$422M +$6.47M +15,475 +1%
Pictet Asset Management
36
Pictet Asset Management
Switzerland
$311M +$23.3M +55,636 +8%
Dimensional Fund Advisors
37
Dimensional Fund Advisors
Texas
$307M +$78.3M +187,359 +31%
UBS Group
38
UBS Group
Switzerland
$303M +$30.5M +73,046 +10%
Assenagon Asset Management
39
Assenagon Asset Management
Luxembourg
$299M +$218M +520,949 +215%
Barclays
40
Barclays
United Kingdom
$291M -$33.6M -80,450 -10%
Swiss National Bank
41
Swiss National Bank
Switzerland
$290M -$15.9M -38,000 -5%
Renaissance Technologies
42
Renaissance Technologies
New York
$288M -$112M -269,000 -27%
Wells Fargo
43
Wells Fargo
California
$281M +$6.38M +15,274 +2%
Sumitomo Mitsui Trust Group
44
Sumitomo Mitsui Trust Group
Japan
$274M +$19.1M +45,623 +7%
HSBC Holdings
45
HSBC Holdings
United Kingdom
$249M -$1.93M -4,629 -0.7%
California Public Employees Retirement System
46
California Public Employees Retirement System
California
$240M -$47M -112,548 -16%
Squarepoint
47
Squarepoint
New York
$238M +$181M +432,149 +246%
Mitsubishi UFJ Asset Management
48
Mitsubishi UFJ Asset Management
Japan
$213M +$8.38M +20,053 +4%
Lazard Asset Management
49
Lazard Asset Management
New York
$213M +$27M +64,513 +13%
Citigroup
50
Citigroup
New York
$211M -$24.7M -59,084 -10%