|
1
|
Fidelity Investments
Boston,
Massachusetts
|
$54.6M
|
+$58K
|
+3,321
|
+0.1%
|
|
|
2
|
Sofinnova Investments
Menlo Park,
California
|
$43.3M
|
–
|
–
|
–
|
|
|
3
|
Abingworth
London,
United Kingdom
|
$40.3M
|
–
|
–
|
–
|
|
|
4
|
Citadel Advisors
Miami,
Florida
|
$28.9M
|
+$582K
|
+33,331
|
+2%
|
|
|
5
|
RA Capital Management
Boston,
Massachusetts
|
$21.5M
|
-$6.76M
|
-387,264
|
-20%
|
|
|
6
|
Kynam Capital Management
Princeton,
New Jersey
|
$20.7M
|
+$17.8M
|
+1,020,384
|
+203%
|
|
|
7
|
|
$9.76M
|
+$652K
|
+37,359
|
+5%
|
|
|
8
|
Vanguard Group
Malvern,
Pennsylvania
|
$9.21M
|
+$1.03M
|
+58,934
|
+10%
|
|
|
9
|
Vivo Capital
Palo Alto,
California
|
$9.07M
|
–
|
–
|
–
|
|
|
10
|
Octagon Capital Advisors
New York
|
$7.83M
|
–
|
–
|
–
|
|
|
11
|
Baker Bros. Advisors
New York
|
$4.54M
|
–
|
–
|
–
|
|
|
12
|
Alphabet Inc
Mountain View,
California
|
$4.11M
|
–
|
–
|
–
|
|
|
13
|
Polar Asset Management Partners
Toronto,
Ontario, Canada
|
$4M
|
+$4.09M
|
+234,300
|
+391%
|
|
|
14
|
Millennium Management
New York
|
$3.76M
|
+$2.49M
|
+142,743
|
+107%
|
|
|
15
|
State Street
Boston,
Massachusetts
|
$3.02M
|
+$934K
|
+53,498
|
+32%
|
|
|
16
|
Geode Capital Management
Boston,
Massachusetts
|
$2.78M
|
+$35.6K
|
+2,041
|
+1%
|
|
|
17
|
Northern Trust
Chicago,
Illinois
|
$1.53M
|
+$53.5K
|
+3,063
|
+3%
|
|
|
18
|
Bank of Montreal
Toronto,
Ontario, Canada
|
$1.41M
|
+$1.69M
|
+96,849
|
New
|
|
|
19
|
|
$1.35M
|
-$884K
|
-50,665
|
-34%
|
|
|
20
|
Bank of New York Mellon
New York
|
$1.02M
|
+$458K
|
+26,248
|
+54%
|
|
|
21
|
Nuveen
Charlotte,
North Carolina
|
$1.01M
|
+$361K
|
+20,699
|
+39%
|
|
|
22
|
Charles Schwab
San Francisco,
California
|
$473K
|
-$907
|
-52
|
-0.1%
|
|
|
23
|
Swiss National Bank
Zurich,
Switzerland
|
$472K
|
+$606K
|
+34,700
|
New
|
|
|
24
|
Bank of America
Charlotte,
North Carolina
|
$292K
|
+$102K
|
+5,850
|
+37%
|
|
|
25
|
International Biotechnology Trust
London,
United Kingdom
|
$281K
|
-$3.26M
|
-186,924
|
-98%
|
|
