UPB

Upstream Bio, Inc. Common Stock
UPB

Overview Fund Activity

82 hedge funds and large institutions have $531M invested in Upstream Bio, Inc. Common Stock in 2025 Q2 according to their latest regulatory filings, with 14 funds opening new positions, 41 increasing their positions, 13 reducing their positions, and 10 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
82
Holders Change
+4
Holders Change %
+5.13%
% of All Funds
1.1%
Holding in Top 10
4
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.05%
New
14
Increased
41
Reduced
13
Closed
10
Calls
–
Puts
–
Net Calls
–
Net Calls Change
–

Top Buyers

1
Vanguard Group
Vanguard Group
Pennsylvania
+$13.9M
2
BlackRock
BlackRock
New York
+$10M
3
Fidelity Investments
Fidelity Investments
Massachusetts
+$7.48M
4
PHP
Parkman Healthcare Partners
Connecticut
+$5.29M
5
Geode Capital Management
Geode Capital Management
Massachusetts
+$2.59M

Top Sellers

1
AllianceBernstein
AllianceBernstein
Tennessee
-$11.7M
2
DTC
Deep Track Capital
Connecticut
-$9.41M
3
SB
Samsara BioCapital
California
-$6.85M
4
Wellington Management Group
Wellington Management Group
Massachusetts
-$968K
5
Millennium Management
Millennium Management
New York
-$378K
Name Holding Trade Value Shares
Change 		Shares
Change %
Northern Trust
26
Northern Trust
Illinois
$2.52M +$1.01M +91,532 +66%
LCM
27
Lynx1 Capital Management
Puerto Rico
$2.41M – – –
Charles Schwab
28
Charles Schwab
California
$1.96M +$506K +46,080 +35%
VCIM
29
Velan Capital Investment Management
Georgia
$1.17M – – –
Morgan Stanley
30
Morgan Stanley
New York
$1.09M +$526K +47,917 +93%
Barclays
31
Barclays
United Kingdom
$1.07M +$791K +71,997 +288%
Alyeska Investment Group
32
Alyeska Investment Group
Illinois
$933K – – –
Bank of New York Mellon
33
Bank of New York Mellon
New York
$876K +$471K +42,854 +116%
NL
34
Nuveen LLC
North Carolina
$812K +$564K +51,350 +227%
RhumbLine Advisers
35
RhumbLine Advisers
Massachusetts
$528K +$381K +34,739 +261%
Susquehanna International Group
36
Susquehanna International Group
Pennsylvania
$464K +$231K +20,999 +99%
Verition Fund Management
37
Verition Fund Management
Connecticut
$368K +$368K +33,505 New
AQR Capital Management
38
AQR Capital Management
Connecticut
$327K +$120K +10,930 +58%
AA
39
ALPS Advisors
Colorado
$318K -$111K -10,103 -26%
AllianceBernstein
40
AllianceBernstein
Tennessee
$270K -$11.7M -1,066,626 -98%
Deutsche Bank
41
Deutsche Bank
Germany
$257K +$90.2K +8,211 +54%
Wells Fargo
42
Wells Fargo
California
$246K +$144K +13,114 +142%
American Century Companies
43
American Century Companies
Missouri
$246K +$246K +22,362 New
MIM
44
MetLife Investment Management
New Jersey
$238K +$117K +10,657 +97%
IIM
45
INTECH Investment Management
Florida
$234K +$65.9K +6,005 +39%
Mirae Asset Global ETFs Holdings
46
Mirae Asset Global ETFs Holdings
Hong Kong
$210K +$96.5K +8,788 +85%
Bank of America
47
Bank of America
North Carolina
$198K +$82.4K +7,500 +71%
T. Rowe Price Associates
48
T. Rowe Price Associates
Maryland
$192K +$192K +17,448 New
JPMorgan Chase & Co
49
JPMorgan Chase & Co
New York
$181K +$14K +1,275 +8%
Invesco
50
Invesco
Georgia
$179K +$10.8K +985 +6%
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