UPB
Upstream Bio Inc
UPB
UPB
82 hedge funds and large institutions have $531M invested in Upstream Bio Inc in 2025 Q2 according to their latest regulatory filings, with 14 funds opening new positions, 41 increasing their positions, 13 reducing their positions, and 10 closing their positions.
New
Increased
Maintained
Reduced
Closed
more repeat investments, than reductions
Existing positions increased: | Existing positions reduced:
more capital invested
Capital invested by funds: $ → $
more first-time investments, than exits
New positions opened: | Existing positions closed:
more ownership
Funds ownership: →
5% more funds holding
Funds holding: 78 → 82 (+4)
0% more funds holding in top 10
Funds holding in top 10: 4 → 4 (0)
Holders
82
Holding in Top 10
4
Calls
–
Puts
–
Top Buyers
| 1 | +$11.7M | |
| 2 | +$8.41M | |
| 3 | +$6.29M | |
| 4 |
PHP
Parkman Healthcare Partners
Stamford,
Connecticut
|
+$4.45M |
| 5 |
Geode Capital Management
Boston,
Massachusetts
|
+$2.18M |
Top Sellers
| 1 | -$9.85M | |
| 2 | -$7.91M | |
| 3 | -$5.76M | |
| 4 |
Wellington Management Group
Boston,
Massachusetts
|
-$814K |
| 5 |
Millennium Management
New York
|
-$378K |