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Tango Therapeutics
TNGX

141 hedge funds and large institutions have $1.18B invested in Tango Therapeutics in 2025 Q3 according to their latest regulatory filings, with 37 funds opening new positions, 48 increasing their positions, 35 reducing their positions, and 10 closing their positions.

New
Increased
Maintained
Reduced
Closed

797% more call options, than puts

Call options by funds: $1.55M | Put options by funds: $173K

270% more first-time investments, than exits

New positions opened: 37 | Existing positions closed: 10

80% more capital invested

Capital invested by funds: $652M → $1.18B (+$524M)

37% more repeat investments, than reductions

Existing positions increased: 48 | Existing positions reduced: 35

23% more funds holding

Funds holding: 115 → 141 (+26)

8.41% more ownership

Funds ownership: 117.39% → 125.8% (+8.4%)

0% more funds holding in top 10

Funds holding in top 10: 7 → 7 (0)

Holders
141
Holders Change
+26
Holders Change %
+22.61%
% of All Funds
1.85%
Holding in Top 10
7
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.09%
New
37
Increased
48
Reduced
35
Closed
10
Calls
$1.55M
Puts
$173K
Net Calls
+$1.38M
Net Calls Change
+$152K

Top Buyers

Rank Fund Capital Flow
1
PBA
Paradigm Biocapital Advisors
New York
+$20.9M
2
Point72 Asset Management
Point72 Asset Management
Connecticut
+$19.8M
3
SL
Siren LLC
Connecticut
+$17M
4
Janus Henderson Group
Janus Henderson Group
United Kingdom
+$15.6M
5
State Street
State Street
Massachusetts
+$13.4M

Top Sellers

Rank Fund Capital Flow
1
Adage Capital Partners
Adage Capital Partners
Massachusetts
-$23M
2
TGI
TRV GP IV
Massachusetts
-$20.3M
3
TCM
TCG Crossover Management
California
-$14.9M
4
NCM
Nantahala Capital Management
Connecticut
-$11M
5
BOCH
Blue Owl Capital Holdings
New York
-$4.7M
Name Holding Trade Value Shares
Change 		Change in
Stake
FAM
51
Fred Alger Management
New York
$1.93M +$264K +38,979 +20%
CAM
52
Congress Asset Management
Massachusetts
$1.92M +$6.27K +926 +0.4%
Fisher Asset Management
53
Fisher Asset Management
Washington
$1.77M -$92.9K -13,725 -6%
TI
54
Trexquant Investment
Connecticut
$1.67M +$1.35M +199,081 New
TGV
55
TRV GP VI
Massachusetts
$1.63M – – –
Bank of New York Mellon
56
Bank of New York Mellon
New York
$1.62M +$29.4K +4,351 +2%
UBS Group
57
UBS Group
Switzerland
$1.35M -$789K -116,624 -42%
SFI
58
Susquehanna Fundamental Investments
Pennsylvania
$1.32M -$17.6K -2,604 -2%
Bank of America
59
Bank of America
North Carolina
$1.31M +$733K +108,302 +230%
Rafferty Asset Management
60
Rafferty Asset Management
New York
$1.22M +$983K +145,316 New
Two Sigma Investments
61
Two Sigma Investments
New York
$1.21M +$827K +122,214 +550%
BOCH
62
Blue Owl Capital Holdings
New York
$1M -$4.7M -695,000 -85%
RhumbLine Advisers
63
RhumbLine Advisers
Massachusetts
$906K -$30K -4,434 -4%
AllianceBernstein
64
AllianceBernstein
Tennessee
$859K -$25.3K -3,740 -4%
Two Sigma Advisers
65
Two Sigma Advisers
New York
$790K +$637K +94,100 New
Susquehanna International Group
66
Susquehanna International Group
Pennsylvania
$746K -$1.04M -153,608 -63%
ECM
67
ExodusPoint Capital Management
New York
$682K +$550K +81,238 New
AQR Capital Management
68
AQR Capital Management
Connecticut
$665K +$1.55K +229 +0.3%
DekaBank Deutsche Girozentrale
69
DekaBank Deutsche Girozentrale
Germany
$497K – – –
Deutsche Bank
70
Deutsche Bank
Germany
$497K +$43.9K +6,488 +12%
Renaissance Technologies
71
Renaissance Technologies
New York
$465K -$69K -10,200 -16%
Wells Fargo
72
Wells Fargo
California
$462K +$39.2K +5,788 +12%
Tudor Investment Corp
73
Tudor Investment Corp
Connecticut
$450K +$363K +53,572 New
MIM
74
MetLife Investment Management
New Jersey
$401K – – –
T. Rowe Price Associates
75
T. Rowe Price Associates
Maryland
$343K +$15.3K +2,268 +6%
1 2
3
4 5

TNGX Hedge Fund Activity: Q3 2025 in Review

141 of the 7,621 institutional investors tracked by Wall St. Rank reported a position in Tango Therapeutics (TNGX) for Q3 2025, worth a combined $1.18B — up 80% from $652M a quarter earlier.

Buyers outnumbered sellers: 37 funds opened new TNGX positions and 10 closed out — a net gain of 27 holders — while 48 added to existing stakes and 35 trimmed.

The largest buyer was Paradigm Biocapital Advisors, opening a new position worth an estimated $20.9M. The largest seller was Adage Capital Partners, cutting an estimated $23M.

  • 141 institutional investors held Tango Therapeutics (TNGX) as of Q3 2025, up from 115 in Q2 2025.
  • Funds reported $1.18B of Tango Therapeutics stock for Q3 2025, up 80% quarter-over-quarter.
  • 37 funds opened new Tango Therapeutics positions in Q3 2025 and 10 closed out, a net change of +27 holders.
  • The largest Tango Therapeutics buyer in Q3 2025 was Paradigm Biocapital Advisors, an estimated $20.9M added.
  • The largest Tango Therapeutics seller in Q3 2025 was Adage Capital Partners, an estimated $23M sold.

Based on aggregated 13F filings for Q3 2025.