Two Sigma Investments
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Two Sigma Investments’s Tango Therapeutics TNGX Stock Holding History

Two Sigma Investments’s Portfolio TNGX Stock Details TNGX Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		$3.62M Buy
173,132
+28,700
+20% +$399K ﹤0.01% 2261
2025
Q4 		$1.28M Hold
144,432
– – ﹤0.01% 2757
2025
Q3 		$1.21M Buy
144,432
+122,214
+550% +$827K ﹤0.01% 2451
2025
Q2 		$114K Sell
22,218
-30,684
-58% -$75.9K ﹤0.01% 2986
2025
Q1 		$72.5K Buy
52,902
+7,906
+18% +$19.4K ﹤0.01% 3001
2024
Q4 		$139K Sell
44,996
-23,166
-34% -$108K ﹤0.01% 2928
2024
Q3 		$525K Sell
68,162
-22,616
-25% -$216K ﹤0.01% 2456
2024
Q2 		$779K Sell
90,778
-216,457
-70% -$1.67M ﹤0.01% 2124
2024
Q1 		$2.44M Buy
307,235
+70,843
+30% +$759K 0.01% 1345
2023
Q4 		$2.34M Buy
236,392
+104,301
+79% +$905K 0.01% 1411
2023
Q3 		$1.49M Buy
132,091
+70,531
+115% +$430K ﹤0.01% 1665
2023
Q2 		$204K Sell
61,560
-11,696
-16% -$42.1K ﹤0.01% 2639
2023
Q1 		$289K Buy
+73,256
New +$425K ﹤0.01% 2433

Other funds holding TNGX

RI
RTW Investments New York $10B AUM 135.35% 1-Year Est. Return
Adage Capital Partners
Adage Capital Partners Boston, Massachusetts $64.8B AUM 42.7% 1-Year Est. Return
BCM
Boxer Capital Management San Diego, California $762M AUM 1,125.36% 1-Year Est. Return
TCM
TCG Crossover Management Palo Alto, California $3.5B AUM 1,165.83% 1-Year Est. Return
Fidelity Investments
Fidelity Investments Boston, Massachusetts $1.9T AUM 41.92% 1-Year Est. Return
FCM
Farallon Capital Management San Francisco, California $17.5B AUM 50.95% 1-Year Est. Return
BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
WP
Woodline Partners San Francisco, California $26.4B AUM 44.85% 1-Year Est. Return
NI
Nextech Invest Zurich, Switzerland $1.42B AUM 304.47% 1-Year Est. Return
TGI
TRV GP IV Boston, Massachusetts $267M AUM 965.83% 1-Year Est. Return

Two Sigma Investments's TNGX Position: Q1 2026 in Review

Two Sigma Investments increased its Tango Therapeutics (TNGX) stake by 20% in Q1 2026, buying an estimated $399K and bringing the position to 173,132 shares worth $3.62M. The position accounts for ﹤0.01% of the portfolio, ranked #2261.

Two Sigma Investments first reported a position in TNGX in Q1 2023 and has held it in 13 quarters since. 194 funds tracked by Wall St. Rank hold TNGX as of Q1 2026.

  • Two Sigma Investments held 173,132 shares of Tango Therapeutics worth $3.62M as of Q1 2026.
  • Two Sigma Investments bought 28,700 Tango Therapeutics shares in Q1 2026, an estimated $399K.
  • Tango Therapeutics made up ﹤0.01% of Two Sigma Investments's portfolio in Q1 2026, its #2261 holding.
  • Two Sigma Investments first reported a position in Tango Therapeutics in Q1 2023 and has held it in 13 quarters since.
  • 194 funds tracked by Wall St. Rank held Tango Therapeutics as of Q1 2026.

Based on Two Sigma Investments's 13F filing for Q1 2026, filed 15 May 2026.