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Tango Therapeutics

122 hedge funds and large institutions have $147M invested in Tango Therapeutics in 2025 Q1 according to their latest regulatory filings, with 15 funds opening new positions, 43 increasing their positions, 39 reducing their positions, and 30 closing their positions.

New
Increased
Maintained
Reduced
Closed

10% more repeat investments, than reductions

Existing positions increased: 43 | Existing positions reduced: 39

0.15% more ownership

Funds ownership: 99.09%99.24% (+0.15%)

11% less funds holding

Funds holding: 137122 (-15)

33% less funds holding in top 10

Funds holding in top 10: 64 (-2)

50% less first-time investments, than exits

New positions opened: 15 | Existing positions closed: 30

55% less capital invested

Capital invested by funds: $329M → $147M (-$182M)

Holders
122
Holders Change
-15
Holders Change %
-10.95%
% of All Funds
1.64%
Holding in Top 10
4
Holding in Top 10 Change
-2
Holding in Top 10 Change %
-33.33%
% of All Funds
0.05%
New
15
Increased
43
Reduced
39
Closed
30
Calls
$2K
Puts
Net Calls
+$2K
Net Calls Change
+$12K
Name Holding Trade Value Shares
Change
Change in
Stake
TGI
1
TRV GP IV
Massachusetts
$23.1M
TCM
2
TCG Crossover Management
California
$14.7M
EC
3
EcoR1 Capital
California
$14.6M
BCM
4
Boxer Capital Management
California
$14.2M
NI
5
Nextech Invest
Switzerland
$7.58M
GS
6
Gilead Sciences
California
$6.65M
FCM
7
Farallon Capital Management
California
$6.32M +$1.5M +610,930 +15%
BlackRock
8
BlackRock
New York
$5.52M -$851K -346,491 -8%
Vanguard Group
9
Vanguard Group
Pennsylvania
$5.31M -$269K -109,680 -3%
T. Rowe Price Investment Management
10
T. Rowe Price Investment Management
Maryland
$4.54M -$81.3K -33,102 -1%
Balyasny Asset Management
11
Balyasny Asset Management
Illinois
$4.41M -$146K -59,625 -2%
NCM
12
Nantahala Capital Management
Connecticut
$4.09M +$451K +183,573 +7%
BCLSI
13
Bain Capital Life Sciences Investors
Massachusetts
$3.72M
SL
14
Siren LLC
Connecticut
$3.51M -$94.7K -38,555 -1%
BOCH
15
Blue Owl Capital Holdings
New York
$2.91M +$957K +389,500 +22%
Marshall Wace
16
Marshall Wace
United Kingdom
$2.52M +$4.52M +1,842,163 New
Millennium Management
17
Millennium Management
New York
$2.02M +$3M +1,221,286 +489%
Geode Capital Management
18
Geode Capital Management
Massachusetts
$1.9M -$7.4K -3,012 -0.2%
State Street
19
State Street
Massachusetts
$1.57M -$213K -86,756 -7%
Acadian Asset Management
20
Acadian Asset Management
Massachusetts
$1.33M +$1.17M +478,203 +97%
Jacobs Levy Equity Management
21
Jacobs Levy Equity Management
New Jersey
$1.01M +$542K +220,529 +43%
ACH
22
ArrowMark Colorado Holdings
Colorado
$970K
Bessemer Group
23
Bessemer Group
New Jersey
$970K
Schroder Investment Management Group
24
Schroder Investment Management Group
United Kingdom
$963K
SB
25
Samsara BioCapital
California
$863K

TNGX Hedge Fund Activity: Q1 2025 in Review

122 of the 7,458 institutional investors tracked by Wall St. Rank reported a position in Tango Therapeutics (TNGX) for Q1 2025, worth a combined $147M — down 55% from $329M a quarter earlier.

Sellers outnumbered buyers: 30 funds closed out of TNGX and 15 opened new positions — a net loss of 15 holders — while 39 trimmed existing stakes and 43 added.

The largest buyer was Marshall Wace, opening a new position worth an estimated $4.52M. The largest seller was Citadel Advisors, cutting an estimated $3.73M.

  • 122 institutional investors held Tango Therapeutics (TNGX) as of Q1 2025, down from 137 in Q4 2024.
  • Funds reported $147M of Tango Therapeutics stock for Q1 2025, down 55% quarter-over-quarter.
  • 15 funds opened new Tango Therapeutics positions in Q1 2025 and 30 closed out, a net change of -15 holders.
  • The largest Tango Therapeutics buyer in Q1 2025 was Marshall Wace, an estimated $4.52M added.
  • The largest Tango Therapeutics seller in Q1 2025 was Citadel Advisors, an estimated $3.73M sold.

Based on aggregated 13F filings for Q1 2025.