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Shattuck Labs

56 hedge funds and large institutions have $87M invested in Shattuck Labs in 2025 Q3 according to their latest regulatory filings, with 14 funds opening new positions, 11 increasing their positions, 23 reducing their positions, and 18 closing their positions.

New
Increased
Maintained
Reduced
Closed

284% more capital invested

Capital invested by funds: $22.7M → $87M (+$64.3M)

0% more funds holding in top 10

Funds holding in top 10: 11 (0)

2.27% less ownership

Funds ownership: 59.89%57.62% (-2.3%)

8% less funds holding

Funds holding: 6156 (-5)

22% less first-time investments, than exits

New positions opened: 14 | Existing positions closed: 18

52% less repeat investments, than reductions

Existing positions increased: 11 | Existing positions reduced: 23

Holders
56
Holders Change
-5
Holders Change %
-8.2%
% of All Funds
0.73%
Holding in Top 10
1
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
0.01%
New
14
Increased
11
Reduced
23
Closed
18
Calls
$224K
Puts
Net Calls
+$224K
Net Calls Change
+$195K
Name Holding Trade Value Shares
Change
Change in
Stake
Adage Capital Partners
1
Adage Capital Partners
Massachusetts
$15.1M +$2M +1,631,127 +35%
O
2
OrbiMed
New York
$15.1M +$7.72M +6,306,127 New
RG
3
Redmile Group
California
$13.2M
PM
4
Prosight Management
Texas
$13M -$1.45M -1,187,740 -18%
Vanguard Group
5
Vanguard Group
Pennsylvania
$5.09M -$24.2K -19,773 -0.9%
6CM
6
683 Capital Management
New York
$3.66M +$535K +437,216 +40%
CEI
7
Clark Estates Inc
New York
$3.53M
PA
8
Pinnacle Associates
New York
$3.32M +$30.6K +25,000 +2%
Bank of America
9
Bank of America
North Carolina
$2.71M +$1.34M +1,094,997 +2,968%
Millennium Management
10
Millennium Management
New York
$1.65M -$186K -152,355 -18%
Marshall Wace
11
Marshall Wace
United Kingdom
$1.57M +$803K +656,653 New
TPC
12
Takeda Pharmaceutical Company
Japan
$1.23M
Geode Capital Management
13
Geode Capital Management
Massachusetts
$1.12M
BlackRock
14
BlackRock
New York
$983K -$575K -470,096 -53%
Two Sigma Investments
15
Two Sigma Investments
New York
$977K +$406K +331,664 +431%
Acadian Asset Management
16
Acadian Asset Management
Massachusetts
$785K +$83.6K +68,330 +26%
Renaissance Technologies
17
Renaissance Technologies
New York
$518K +$219K +178,767 +469%
State Street
18
State Street
Massachusetts
$422K
Pathstone Holdings
19
Pathstone Holdings
New Jersey
$375K -$192K -157,083 -50%
Two Sigma Advisers
20
Two Sigma Advisers
New York
$269K +$121K +98,677 +705%
Bank of New York Mellon
21
Bank of New York Mellon
New York
$264K
Jane Street
22
Jane Street
New York
$237K -$233K -190,624 -66%
Aberdeen Group
23
Aberdeen Group
United Kingdom
$226K +$116K +94,504 New
Northern Trust
24
Northern Trust
Illinois
$218K -$24.1K -19,711 -18%
LFWA
25
LBJ Family Wealth Advisors
Texas
$196K +$101K +82,177 New

STTK Hedge Fund Activity: Q3 2025 in Review

56 of the 7,620 institutional investors tracked by Wall St. Rank reported a position in Shattuck Labs (STTK) for Q3 2025, worth a combined $87M — up 284% from $22.7M a quarter earlier.

Sellers outnumbered buyers: 18 funds closed out of STTK and 14 opened new positions — a net loss of 4 holders — while 23 trimmed existing stakes and 11 added.

The largest buyer was OrbiMed, opening a new position worth an estimated $7.72M. The largest seller was Prosight Management, cutting an estimated $1.45M.

  • 56 institutional investors held Shattuck Labs (STTK) as of Q3 2025, down from 61 in Q2 2025.
  • Funds reported $87M of Shattuck Labs stock for Q3 2025, up 284% quarter-over-quarter.
  • 14 funds opened new Shattuck Labs positions in Q3 2025 and 18 closed out, a net change of -4 holders.
  • The largest Shattuck Labs buyer in Q3 2025 was OrbiMed, an estimated $7.72M added.
  • The largest Shattuck Labs seller in Q3 2025 was Prosight Management, an estimated $1.45M sold.

Based on aggregated 13F filings for Q3 2025.