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SION

Sionna Therapeutics
SION

101 hedge funds and large institutions have $1.81B invested in Sionna Therapeutics in 2025 Q4 according to their latest regulatory filings, with 30 funds opening new positions, 39 increasing their positions, 20 reducing their positions, and 7 closing their positions.

New
Increased
Maintained
Reduced
Closed

329% more first-time investments, than exits

New positions opened: 30 | Existing positions closed: 7

95% more repeat investments, than reductions

Existing positions increased: 39 | Existing positions reduced: 20

75% more funds holding in top 10

Funds holding in top 10: 4 → 7 (+3)

44% more capital invested

Capital invested by funds: $1.26B → $1.81B (+$548M)

29% more funds holding

Funds holding: 78 → 101 (+23)

1.42% more ownership

Funds ownership: 97.06% → 98.48% (+1.4%)

Holders
101
Holders Change
+23
Holders Change %
+29.49%
% of All Funds
1.23%
Holding in Top 10
7
Holding in Top 10 Change
+3
Holding in Top 10 Change %
+75%
% of All Funds
0.09%
New
30
Increased
39
Reduced
20
Closed
7
Calls
–
Puts
–
Net Calls
–
Net Calls Change
–

Top Buyers

Rank Fund Capital Flow
1
Citadel Advisors
Citadel Advisors
Florida
+$39.9M
2
EAM
Eventide Asset Management
Massachusetts
+$24.2M
3
State Street
State Street
Massachusetts
+$17.2M
4
BlackRock
BlackRock
New York
+$16.9M
5
T. Rowe Price Associates
T. Rowe Price Associates
Maryland
+$7.34M

Top Sellers

Rank Fund Capital Flow
1
JP Morgan Chase
JP Morgan Chase
New York
-$28.3M
2
AVLSA
Atlas Venture Life Science Advisors
Massachusetts
-$23.5M
3
RCM
RA Capital Management
Massachusetts
-$20.5M
4
B
Braidwell
Connecticut
-$9.24M
5
SCM
Soleus Capital Management
Connecticut
-$5.5M
Name Holding Trade Value Shares
Change 		Change in
Stake
Charles Schwab
26
Charles Schwab
California
$5.09M +$462K +12,190 +11%
AGP
27
Artia Global Partners
Florida
$4.93M +$4.54M +119,741 New
TD Asset Management
28
TD Asset Management
Ontario, Canada
$4.66M +$996K +26,270 +30%
Northern Trust
29
Northern Trust
Illinois
$4.61M +$546K +14,405 +15%
Invesco
30
Invesco
Georgia
$4.57M +$4.22M +111,162 New
Ameriprise
31
Ameriprise
Minnesota
$4.18M -$1.95M -51,508 -34%
RSCM
32
Rock Springs Capital Management
Maryland
$4.09M – – –
UBS Group
33
UBS Group
Switzerland
$3.67M +$1.61M +42,511 +91%
DCM
34
Driehaus Capital Management
Illinois
$3.45M – – –
Millennium Management
35
Millennium Management
New York
$3.31M -$5.06M -133,539 -62%
Ensign Peak Advisors
36
Ensign Peak Advisors
Utah
$3.29M +$3.03M +79,862 New
LP
37
Longaeva Partners
Illinois
$3.28M +$693K +18,272 +30%
Manulife (Manufacturers Life Insurance)
38
Manulife (Manufacturers Life Insurance)
Ontario, Canada
$2.87M +$1.42M +37,344 +116%
SGM
39
Seven Grand Managers
New York
$2.06M +$1.9M +50,000 New
Morgan Stanley
40
Morgan Stanley
New York
$2.05M +$1.03M +27,039 +118%
Barclays
41
Barclays
United Kingdom
$1.98M +$1.16M +30,529 +173%
Bank of America
42
Bank of America
North Carolina
$1.79M +$1.4M +37,026 +566%
SCM
43
Silverarc Capital Management
Massachusetts
$1.71M -$2.55M -67,341 -62%
Wellington Management Group
44
Wellington Management Group
Massachusetts
$1.58M -$147K -3,887 -9%
AA
45
ALPS Advisors
Colorado
$1.51M +$1.39M +36,648 New
Goldman Sachs
46
Goldman Sachs
New York
$1.49M +$914K +24,091 +198%
Bank of New York Mellon
47
Bank of New York Mellon
New York
$1.45M +$291K +7,671 +28%
Polen Capital Management
48
Polen Capital Management
Florida
$1.29M – – –
Rafferty Asset Management
49
Rafferty Asset Management
New York
$1.02M +$936K +24,690 New
N
50
Nuveen
North Carolina
$976K +$292K +7,694 +48%
1
2
3 4 5

SION Hedge Fund Activity: Q4 2025 in Review

101 of the 8,223 institutional investors tracked by Wall St. Rank reported a position in Sionna Therapeutics (SION) for Q4 2025, worth a combined $1.81B — up 44% from $1.26B a quarter earlier.

Buyers outnumbered sellers: 30 funds opened new SION positions and 7 closed out — a net gain of 23 holders — while 39 added to existing stakes and 20 trimmed.

The largest buyer was Citadel Advisors, adding an estimated $39.9M. The largest seller was JP Morgan Chase, cutting an estimated $28.3M.

  • 101 institutional investors held Sionna Therapeutics (SION) as of Q4 2025, up from 78 in Q3 2025.
  • Funds reported $1.81B of Sionna Therapeutics stock for Q4 2025, up 44% quarter-over-quarter.
  • 30 funds opened new Sionna Therapeutics positions in Q4 2025 and 7 closed out, a net change of +23 holders.
  • The largest Sionna Therapeutics buyer in Q4 2025 was Citadel Advisors, an estimated $39.9M added.
  • The largest Sionna Therapeutics seller in Q4 2025 was JP Morgan Chase, an estimated $28.3M sold.

Based on aggregated 13F filings for Q4 2025.