Schrodinger
SDGR
224 hedge funds and large institutions have $1.4B invested in Schrodinger in 2025 Q3 according to their latest regulatory filings, with 27 funds opening new positions, 63 increasing their positions, 95 reducing their positions, and 35 closing their positions.
477% more call options, than puts
Call options by funds: $35.7M | Put options by funds: $6.18M
2% less capital invested
Capital invested by funds: $1.43B → $1.4B (-$30M)
2.39% less ownership
Funds ownership: 110.4% → 108.01% (-2.4%)
3% less funds holding
Funds holding: 232 → 224 (-8)
23% less first-time investments, than exits
New positions opened: 27 | Existing positions closed: 35
34% less repeat investments, than reductions
Existing positions increased: 63 | Existing positions reduced: 95
Top Buyers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
Millennium Management
New York
|
+$28.5M |
| 2 |
Lazard Asset Management
New York
|
+$18.6M |
| 3 |
Sumitomo Mitsui Trust Group
Minato-Ku, Tokyo,
Japan
|
+$18.2M |
| 4 |
Morgan Stanley
New York
|
+$11.8M |
| 5 |
Massachusetts Financial Services
Boston,
Massachusetts
|
+$11.6M |
Top Sellers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
CCM
Cadian Capital Management
New York
|
-$61.3M |
| 2 |
FCM
Farallon Capital Management
San Francisco,
California
|
-$16.5M |
| 3 |
Bank of America
Charlotte,
North Carolina
|
-$8.2M |
| 4 |
UBS Group
Zurich,
Switzerland
|
-$7.76M |
| 5 |
Vanguard Group
Malvern,
Pennsylvania
|
-$5.58M |
| Name | Holding | Trade Value |
Shares Change |
Change in Stake |
|
|---|---|---|---|---|---|
|
N
251
Numerai
San Francisco,
California
| – | -$216K | -10,731 | Closed |
|
252
Mariner
Overland Park,
Kansas
| – | -$215K | -10,693 | Closed |
|
|
SSG
253
Summit Securities Group
New York
| – | -$140K | -6,962 | Closed |
|
|
BIG
254
Brooklyn Investment Group
Brooklyn,
New York
| – | -$4.14K | -206 | Closed |
|
|
OP
255
ORG Partners
Roanoke,
Indiana
| – | -$927 | -45 | Closed |
|
|
MAWAG
256
Mid-American Wealth Advisory Group
Kansas City,
Missouri
| – | -$322 | -16 | Closed |
|
|
MYIA
257
Mount Yale Investment Advisors
Denver,
Colorado
| – | -$201 | -10 | Closed |
|
|
NA
258
NewEdge Advisors
New Orleans,
Louisiana
| – | -$20 | -1 | Closed |
|
SDGR Hedge Fund Activity: Q3 2025 in Review
224 of the 7,620 institutional investors tracked by Wall St. Rank reported a position in Schrodinger (SDGR) for Q3 2025, worth a combined $1.4B — down 2.1% from $1.43B a quarter earlier.
Sellers outnumbered buyers: 35 funds closed out of SDGR and 27 opened new positions — a net loss of 8 holders — while 95 trimmed existing stakes and 63 added.
The largest buyer was Millennium Management, adding an estimated $28.5M. The largest seller was Cadian Capital Management, exiting entirely with an estimated $61.3M sold.
- 224 institutional investors held Schrodinger (SDGR) as of Q3 2025, down from 232 in Q2 2025.
- Funds reported $1.4B of Schrodinger stock for Q3 2025, down 2.1% quarter-over-quarter.
- 27 funds opened new Schrodinger positions in Q3 2025 and 35 closed out, a net change of -8 holders.
- The largest Schrodinger buyer in Q3 2025 was Millennium Management, an estimated $28.5M added.
- The largest Schrodinger seller in Q3 2025 was Cadian Capital Management, an estimated $61.3M sold.
Based on aggregated 13F filings for Q3 2025.