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Relay Therapeutics

199 hedge funds and large institutions have $867M invested in Relay Therapeutics in 2025 Q3 according to their latest regulatory filings, with 20 funds opening new positions, 63 increasing their positions, 63 reducing their positions, and 26 closing their positions.

New
Increased
Maintained
Reduced
Closed

2,019% more call options, than puts

Call options by funds: $3.98M | Put options by funds: $188K

47% more capital invested

Capital invested by funds: $592M → $867M (+$276M)

0% more funds holding in top 10

Funds holding in top 10: 55 (0)

0% more repeat investments, than reductions

Existing positions increased: 63 | Existing positions reduced: 63

3.34% less ownership

Funds ownership: 99.71%96.38% (-3.3%)

4% less funds holding

Funds holding: 208199 (-9)

23% less first-time investments, than exits

New positions opened: 20 | Existing positions closed: 26

Holders
199
Holders Change
-9
Holders Change %
-4.33%
% of All Funds
2.61%
Holding in Top 10
5
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
0.07%
New
20
Increased
63
Reduced
63
Closed
26
Calls
$3.98M
Puts
$188K
Net Calls
+$3.79M
Net Calls Change
+$3.92M
Name Holding Trade Value Shares
Change
Change in
Stake
Charles Schwab
26
Charles Schwab
California
$5.8M +$19.3K +5,071 +0.5%
Two Sigma Investments
27
Two Sigma Investments
New York
$5.72M +$276K +72,251 +7%
Renaissance Technologies
28
Renaissance Technologies
New York
$5.34M -$1.85M -485,100 -32%
WP
29
Woodline Partners
California
$5.31M
FCMI
30
Foresite Capital Management IV
California
$5.22M
Millennium Management
31
Millennium Management
New York
$3.88M -$4.29M -1,126,318 -60%
Bessemer Group
32
Bessemer Group
New Jersey
$3.05M -$255 -67 -0%
ACH
33
ArrowMark Colorado Holdings
Colorado
$2.82M
Acadian Asset Management
34
Acadian Asset Management
Massachusetts
$2.61M -$1.12M -293,381 -37%
EP
35
Eversept Partners
New York
$2.5M -$207K -54,353 -10%
IC
36
Ikarian Capital
Texas
$2.44M -$1.05M -275,946 -37%
JP Morgan Chase
37
JP Morgan Chase
New York
$2.41M -$14.8M -3,876,024 -89%
Barclays
38
Barclays
United Kingdom
$2.41M -$361K -94,643 -17%
RPAM
39
Rhenman & Partners Asset Management
Sweden
$2.4M
CAM
40
Congress Asset Management
Massachusetts
$2.13M +$961K +252,142 +161%
AG
41
Algert Global
California
$2.13M -$2.26M -593,176 -59%
American Century Companies
42
American Century Companies
Missouri
$2.06M +$169K +44,284 +13%
Franklin Resources
43
Franklin Resources
California
$1.98M -$56.3K -14,759 -4%
Bank of New York Mellon
44
Bank of New York Mellon
New York
$1.94M +$50.4K +13,207 +4%
Invesco
45
Invesco
Georgia
$1.89M +$335K +87,807 +32%
SPS
46
Susquehanna Portfolio Strategies
Pennsylvania
$1.77M +$382K +100,266 +42%
N
47
Nuveen
North Carolina
$1.51M
HS
48
HighVista Strategies
Massachusetts
$1.26M +$346K +90,758 +61%
Swiss National Bank
49
Swiss National Bank
Switzerland
$1.21M +$21.7K +5,700 +3%
TAM
50
TFG Asset Management
Cayman Islands
$1.16M -$1.81M -475,877 -68%

RLAY Hedge Fund Activity: Q3 2025 in Review

199 of the 7,621 institutional investors tracked by Wall St. Rank reported a position in Relay Therapeutics (RLAY) for Q3 2025, worth a combined $867M — up 47% from $592M a quarter earlier.

Sellers outnumbered buyers: 26 funds closed out of RLAY and 20 opened new positions — a net loss of 6 holders — while 63 trimmed existing stakes and 63 added.

The largest buyer was Commodore Capital, adding an estimated $13.9M. The largest seller was JP Morgan Chase, cutting an estimated $14.8M.

  • 199 institutional investors held Relay Therapeutics (RLAY) as of Q3 2025, down from 208 in Q2 2025.
  • Funds reported $867M of Relay Therapeutics stock for Q3 2025, up 47% quarter-over-quarter.
  • 20 funds opened new Relay Therapeutics positions in Q3 2025 and 26 closed out, a net change of -6 holders.
  • The largest Relay Therapeutics buyer in Q3 2025 was Commodore Capital, an estimated $13.9M added.
  • The largest Relay Therapeutics seller in Q3 2025 was JP Morgan Chase, an estimated $14.8M sold.

Based on aggregated 13F filings for Q3 2025.