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Name Holding Trade Value Shares
Change
Change in
Stake
BlackRock
1
BlackRock
New York
$173M -$2.28M -76,847 -1%
Vanguard Group
2
Vanguard Group
Pennsylvania
$113M +$452K +15,219 +0.4%
JP Morgan Chase
3
JP Morgan Chase
New York
$107M -$5.64M -190,241 -4%
State Street
4
State Street
Massachusetts
$69.2M -$5.38M -181,390 -6%
RG
5
Redmile Group
California
$50.7M -$2.59M -87,451 -4%
RI
6
RTW Investments
New York
$48.8M
Dimensional Fund Advisors
7
Dimensional Fund Advisors
Texas
$33.1M +$5.24M +176,607 +16%
ACM
8
Aquilo Capital Management
California
$25.6M -$5.93M -200,000 -17%
Geode Capital Management
9
Geode Capital Management
Massachusetts
$18.7M +$232K +7,805 +1%
First Manhattan
10
First Manhattan
New York
$18.7M
Goldman Sachs
11
Goldman Sachs
New York
$16.7M +$3.89M +131,038 +26%
MB
12
MPM BioImpact
Massachusetts
$16.4M +$18.4M +619,083 New
Northern Trust
13
Northern Trust
Illinois
$12.9M +$1.93M +65,060 +15%
Invesco
14
Invesco
Georgia
$11.1M -$2.95M -99,514 -19%
WM
15
WS Management
Florida
$10.5M -$593K -20,000 -5%
Morgan Stanley
16
Morgan Stanley
New York
$9.2M -$4.71M -158,675 -31%
Bank of New York Mellon
17
Bank of New York Mellon
New York
$8.99M +$139K +4,695 +1%
Norges Bank
18
Norges Bank
Norway
$8.63M
American Century Companies
19
American Century Companies
Missouri
$8.32M +$2.23M +75,053 +31%
Charles Schwab
20
Charles Schwab
California
$7.37M +$131K +4,431 +2%
AI
21
ArchPoint Investors
Florida
$6.68M -$16.4K -553 -0.2%
Principal Financial Group
22
Principal Financial Group
Iowa
$6.45M -$442K -14,902 -6%
Ameriprise
23
Ameriprise
Minnesota
$5.96M -$234K -7,885 -3%
T. Rowe Price Associates
24
T. Rowe Price Associates
Maryland
$5.84M +$34K +1,146 +0.5%
SI
25
Sofinnova Investments
California
$5.66M -$16.7M -562,665 -72%