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Name Holding Trade Value Shares
Change
Change in
Stake
BlackRock
1
BlackRock
New York
$241M -$3.68M -102,939 -2%
Vanguard Group
2
Vanguard Group
Pennsylvania
$153M +$269K +7,527 +0.2%
JP Morgan Chase
3
JP Morgan Chase
New York
$145M +$7.9M +220,966 +6%
State Street
4
State Street
Massachusetts
$88M -$1.14M -31,906 -1%
RG
5
Redmile Group
California
$83.1M -$7.23M -202,112 -9%
RI
6
RTW Investments
New York
$68.3M +$48M +1,341,166 +322%
Dimensional Fund Advisors
7
Dimensional Fund Advisors
Texas
$37M +$4.46M +124,616 +15%
Geode Capital Management
8
Geode Capital Management
Massachusetts
$25.7M +$1.24M +34,771 +6%
ACM
9
Aquilo Capital Management
California
$23.1M +$1.29M +36,000 +6%
UBS Group
10
UBS Group
Switzerland
$20.4M +$1.45M +40,565 +8%
Northern Trust
11
Northern Trust
Illinois
$18.6M +$1.41M +39,515 +9%
Morgan Stanley
12
Morgan Stanley
New York
$18.1M +$7.31M +204,340 +78%
Invesco
13
Invesco
Georgia
$18M +$8.41M +235,216 +103%
HA
14
HHLR Advisors
Cayman Islands
$17.7M
Korea Investment Corp
15
Korea Investment Corp
South Korea
$17.7M -$426K -11,900 -3%
SI
16
Sofinnova Investments
California
$16.6M +$2.36M +66,005 +18%
First Manhattan
17
First Manhattan
New York
$15.3M +$2.15M +60,178 +18%
Goldman Sachs
18
Goldman Sachs
New York
$14.9M +$797K +22,277 +6%
FM
19
Frazier Management
Washington
$13.7M
Bank of New York Mellon
20
Bank of New York Mellon
New York
$12.4M -$1.04M -29,129 -8%
Norges Bank
21
Norges Bank
Norway
$12.2M -$915K -25,572 -8%
AI
22
ArchPoint Investors
Florida
$11.2M +$1.29M +36,078 +14%
T. Rowe Price Associates
23
T. Rowe Price Associates
Maryland
$10.9M -$513K -14,330 -5%
Charles Schwab
24
Charles Schwab
California
$10.3M +$694K +19,407 +8%
SFI
25
Sonic Fund II
Hawaii
$10.2M