Repligen
RGEN
474 hedge funds and large institutions have $10.2B invested in Repligen in 2025 Q4 according to their latest regulatory filings, with 96 funds opening new positions, 149 increasing their positions, 145 reducing their positions, and 63 closing their positions.
167% more funds holding in top 10
Funds holding in top 10: 3 → 8 (+5)
52% more first-time investments, than exits
New positions opened: 96 | Existing positions closed: 63
28% more capital invested
Capital invested by funds: $8B → $10.2B (+$2.23B)
5% more funds holding
Funds holding: 453 → 474 (+21)
4.61% more ownership
Funds ownership: 106.3% → 110.91% (+4.6%)
3% more repeat investments, than reductions
Existing positions increased: 149 | Existing positions reduced: 145
52% less call options, than puts
Call options by funds: $33.6M | Put options by funds: $70.3M
Top Buyers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
Massachusetts Financial Services
Boston,
Massachusetts
|
+$190M |
| 2 |
T. Rowe Price Associates
Baltimore,
Maryland
|
+$171M |
| 3 |
RI
RTW Investments
New York
|
+$167M |
| 4 |
Franklin Resources
San Mateo,
California
|
+$106M |
| 5 |
FAM
Fred Alger Management
New York
|
+$86.6M |
Top Sellers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
Balyasny Asset Management
Chicago,
Illinois
|
-$102M |
| 2 |
Point72 Asset Management
Stamford,
Connecticut
|
-$68M |
| 3 |
Holocene Advisors
New York
|
-$65.2M |
| 4 |
BCM
Brown Capital Management
Baltimore,
Maryland
|
-$61.8M |
| 5 |
PC
PointState Capital
New York
|
-$54.7M |
RGEN Hedge Fund Activity: Q4 2025 in Review
474 of the 8,266 institutional investors tracked by Wall St. Rank reported a position in Repligen (RGEN) for Q4 2025, worth a combined $10.2B — up 28% from $8B a quarter earlier.
Buyers outnumbered sellers: 96 funds opened new RGEN positions and 63 closed out — a net gain of 33 holders — while 149 added to existing stakes and 145 trimmed.
The largest buyer was Massachusetts Financial Services, opening a new position worth an estimated $190M. The largest seller was Balyasny Asset Management, cutting an estimated $102M.
- 474 institutional investors held Repligen (RGEN) as of Q4 2025, up from 453 in Q3 2025.
- Funds reported $10.2B of Repligen stock for Q4 2025, up 28% quarter-over-quarter.
- 96 funds opened new Repligen positions in Q4 2025 and 63 closed out, a net change of +33 holders.
- The largest Repligen buyer in Q4 2025 was Massachusetts Financial Services, an estimated $190M added.
- The largest Repligen seller in Q4 2025 was Balyasny Asset Management, an estimated $102M sold.
Based on aggregated 13F filings for Q4 2025.