We are live on ! Find out more
PYXS icon

Pyxis Oncology
PYXS

88 hedge funds and large institutions have $29.6M invested in Pyxis Oncology in 2025 Q1 according to their latest regulatory filings, with 11 funds opening new positions, 21 increasing their positions, 26 reducing their positions, and 22 closing their positions.

New
Increased
Maintained
Reduced
Closed

14% more call options, than puts

Call options by funds: $41K | Put options by funds: $36K

3.95% less ownership

Funds ownership: 53.06% → 49.11% (-3.9%)

11% less funds holding

Funds holding: 99 → 88 (-11)

19% less repeat investments, than reductions

Existing positions increased: 21 | Existing positions reduced: 26

40% less capital invested

Capital invested by funds: $49.2M → $29.6M (-$19.6M)

50% less funds holding in top 10

Funds holding in top 10: 4 → 2 (-2)

50% less first-time investments, than exits

New positions opened: 11 | Existing positions closed: 22

Holders
88
Holders Change
-11
Holders Change %
-11.11%
% of All Funds
1.18%
Holding in Top 10
2
Holding in Top 10 Change
-2
Holding in Top 10 Change %
-50%
% of All Funds
0.03%
New
11
Increased
21
Reduced
26
Closed
22
Calls
$41K
Puts
$36K
Net Calls
+$5K
Net Calls Change
-$1.5M

Top Buyers

1
TCM
Tang Capital Management
California
+$1.47M
2
P8IP
Pier 88 Investment Partners
California
+$390K
3
Renaissance Technologies
Renaissance Technologies
New York
+$385K
4
Morgan Stanley
Morgan Stanley
New York
+$272K
5
6CM
683 Capital Management
New York
+$180K

Top Sellers

1
Jacobs Levy Equity Management
Jacobs Levy Equity Management
New Jersey
-$939K
2
Millennium Management
Millennium Management
New York
-$661K
3
HA
HHLR Advisors
Cayman Islands
-$597K
4
American Century Companies
American Century Companies
Missouri
-$365K
5
PA
Perceptive Advisors
New York
-$294K
Name Holding Trade Value Shares
Change 		Change in
Stake
Invesco
51
Invesco
Georgia
$24.3K -$748 -561 -2%
CF
52
Corebridge Financial
Texas
$23.7K -$152 -114 -0.5%
T. Rowe Price Associates
53
T. Rowe Price Associates
Maryland
$23K +$8.67K +6,500 +41%
Osaic Holdings
54
Osaic Holdings
Arizona
$21.9K – – –
LPL Financial
55
LPL Financial
California
$15.8K -$8.67K -6,500 -29%
VOYA Investment Management
56
VOYA Investment Management
Georgia
$15.6K – – –
Squarepoint
57
Squarepoint
New York
$14.6K +$19.9K +14,914 New
AllianceBernstein
58
AllianceBernstein
Tennessee
$13.2K – – –
ProShare Advisors
59
ProShare Advisors
Maryland
$13.1K -$4.28K -3,207 -19%
VPIM
60
Vanguard Personalized Indexing Management
California
$12.7K +$17.3K +12,987 New
CUAMC
61
China Universal Asset Management Company
China
$11.7K -$909 -681 -5%
TRCT
62
Tower Research Capital (TRC)
New York
$10.9K +$4.96K +3,720 +50%
CWM
63
CIBC World Markets
New York
$10.7K +$14.6K +10,945 New
PFSRSONJ
64
Police & Firemen's Retirement System of New Jersey
New Jersey
$9.62K – – –
Simplex Trading
65
Simplex Trading
Illinois
$8K +$7.28K +5,459 +163%
WCM
66
Winthrop Capital Management
Indiana
$6K – – –
AIP
67
Ameritas Investment Partners
Nebraska
$4.69K – – –
Legal & General Group
68
Legal & General Group
United Kingdom
$4.13K – – –
BNP Paribas Financial Markets
69
BNP Paribas Financial Markets
France
$3.59K -$2.99K -2,243 -38%
California State Teachers Retirement System (CalSTRS)
70
California State Teachers Retirement System (CalSTRS)
California
$3.47K – – –
Carson Wealth (CWM LLC)
71
Carson Wealth (CWM LLC)
Nebraska
$3K +$4.19K +3,140 +1,276%
Group One Trading
72
Group One Trading
Illinois
$2.95K +$4.02K +3,010 New
Mirae Asset Global Investments
73
Mirae Asset Global Investments
South Korea
$2.11K +$11 +8 +0.4%
Federated Hermes
74
Federated Hermes
Pennsylvania
$2.03K +$2.77K +2,074 New
AB
75
Amalgamated Bank
New York
$2K – – –
1 2
3
4 5

PYXS Hedge Fund Activity: Q1 2025 in Review

88 of the 7,457 institutional investors tracked by Wall St. Rank reported a position in Pyxis Oncology (PYXS) for Q1 2025, worth a combined $29.6M — down 40% from $49.2M a quarter earlier.

Sellers outnumbered buyers: 22 funds closed out of PYXS and 11 opened new positions — a net loss of 11 holders — while 26 trimmed existing stakes and 21 added.

The largest buyer was Tang Capital Management, opening a new position worth an estimated $1.47M. The largest seller was Jacobs Levy Equity Management, exiting entirely with an estimated $939K sold.

  • 88 institutional investors held Pyxis Oncology (PYXS) as of Q1 2025, down from 99 in Q4 2024.
  • Funds reported $29.6M of Pyxis Oncology stock for Q1 2025, down 40% quarter-over-quarter.
  • 11 funds opened new Pyxis Oncology positions in Q1 2025 and 22 closed out, a net change of -11 holders.
  • The largest Pyxis Oncology buyer in Q1 2025 was Tang Capital Management, an estimated $1.47M added.
  • The largest Pyxis Oncology seller in Q1 2025 was Jacobs Levy Equity Management, an estimated $939K sold.

Based on aggregated 13F filings for Q1 2025.