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Pyxis Oncology
PYXS

88 hedge funds and large institutions have $29.6M invested in Pyxis Oncology in 2025 Q1 according to their latest regulatory filings, with 11 funds opening new positions, 21 increasing their positions, 26 reducing their positions, and 22 closing their positions.

New
Increased
Maintained
Reduced
Closed

14% more call options, than puts

Call options by funds: $41K | Put options by funds: $36K

3.95% less ownership

Funds ownership: 53.06% → 49.11% (-3.9%)

11% less funds holding

Funds holding: 99 → 88 (-11)

19% less repeat investments, than reductions

Existing positions increased: 21 | Existing positions reduced: 26

40% less capital invested

Capital invested by funds: $49.2M → $29.6M (-$19.6M)

50% less funds holding in top 10

Funds holding in top 10: 4 → 2 (-2)

50% less first-time investments, than exits

New positions opened: 11 | Existing positions closed: 22

Holders
88
Holders Change
-11
Holders Change %
-11.11%
% of All Funds
1.18%
Holding in Top 10
2
Holding in Top 10 Change
-2
Holding in Top 10 Change %
-50%
% of All Funds
0.03%
New
11
Increased
21
Reduced
26
Closed
22
Calls
$41K
Puts
$36K
Net Calls
+$5K
Net Calls Change
-$1.5M

Top Buyers

1
TCM
Tang Capital Management
California
+$1.47M
2
P8IP
Pier 88 Investment Partners
California
+$390K
3
Renaissance Technologies
Renaissance Technologies
New York
+$385K
4
Morgan Stanley
Morgan Stanley
New York
+$272K
5
6CM
683 Capital Management
New York
+$180K

Top Sellers

1
Jacobs Levy Equity Management
Jacobs Levy Equity Management
New Jersey
-$939K
2
Millennium Management
Millennium Management
New York
-$661K
3
HA
HHLR Advisors
Cayman Islands
-$597K
4
American Century Companies
American Century Companies
Missouri
-$365K
5
PA
Perceptive Advisors
New York
-$294K
Name Holding Trade Value Shares
Change 		Change in
Stake
Royal Bank of Canada
26
Royal Bank of Canada
Ontario, Canada
$95K +$92.1K +69,006 +250%
Fidelity Investments
27
Fidelity Investments
Massachusetts
$84.9K +$2.36K +1,767 +2%
Acadian Asset Management
28
Acadian Asset Management
Massachusetts
$81K +$112K +84,122 New
BCM
29
Bridgeway Capital Management
Texas
$79.2K -$252K -189,200 -70%
YF
30
Yu Fan
$67.9K – – –
RhumbLine Advisers
31
RhumbLine Advisers
Massachusetts
$66.8K +$407 +305 +0.4%
Susquehanna International Group
32
Susquehanna International Group
Pennsylvania
$63.6K -$4.12K -3,087 -5%
CCC
33
Cable Car Capital
California
$60.4K – – –
SEI Investments
34
SEI Investments
Pennsylvania
$59.9K – – –
Barclays
35
Barclays
United Kingdom
$53K -$30.6K -22,904 -30%
UOC
36
University of Chicago
Illinois
$47.8K – – –
Qube Research & Technologies (QRT)
37
Qube Research & Technologies (QRT)
United Kingdom
$44.2K +$27.5K +20,604 +84%
Commonwealth Equity Services
38
Commonwealth Equity Services
Massachusetts
$42K +$22.7K +17,000 +65%
Bank of America
39
Bank of America
North Carolina
$39.5K -$17.9K -13,422 -25%
AQR Capital Management
40
AQR Capital Management
Connecticut
$39.5K -$13.1K -9,810 -20%
Verition Fund Management
41
Verition Fund Management
Connecticut
$37.5K +$51K +38,260 New
Dimensional Fund Advisors
42
Dimensional Fund Advisors
Texas
$35.8K -$99.4K -74,535 -67%
Citigroup
43
Citigroup
New York
$34.3K -$9.4K -7,048 -17%
IIM
44
INTECH Investment Management
Florida
$31.5K +$12.9K +9,682 +43%
Wells Fargo
45
Wells Fargo
California
$29.3K +$1.25K +941 +3%
Mirae Asset Global ETFs Holdings
46
Mirae Asset Global ETFs Holdings
Hong Kong
$28.7K +$1.67K +1,248 +4%
Deutsche Bank
47
Deutsche Bank
Germany
$27.8K -$2.55K -1,910 -6%
JP Morgan Chase
48
JP Morgan Chase
New York
$27.6K +$1.41K +1,059 +4%
Cetera Investment Advisers
49
Cetera Investment Advisers
Illinois
$27.3K +$1.33K +1,000 +4%
American Century Companies
50
American Century Companies
Missouri
$25.8K -$365K -273,584 -91%
1
2
3 4 5

PYXS Hedge Fund Activity: Q1 2025 in Review

88 of the 7,457 institutional investors tracked by Wall St. Rank reported a position in Pyxis Oncology (PYXS) for Q1 2025, worth a combined $29.6M — down 40% from $49.2M a quarter earlier.

Sellers outnumbered buyers: 22 funds closed out of PYXS and 11 opened new positions — a net loss of 11 holders — while 26 trimmed existing stakes and 21 added.

The largest buyer was Tang Capital Management, opening a new position worth an estimated $1.47M. The largest seller was Jacobs Levy Equity Management, exiting entirely with an estimated $939K sold.

  • 88 institutional investors held Pyxis Oncology (PYXS) as of Q1 2025, down from 99 in Q4 2024.
  • Funds reported $29.6M of Pyxis Oncology stock for Q1 2025, down 40% quarter-over-quarter.
  • 11 funds opened new Pyxis Oncology positions in Q1 2025 and 22 closed out, a net change of -11 holders.
  • The largest Pyxis Oncology buyer in Q1 2025 was Tang Capital Management, an estimated $1.47M added.
  • The largest Pyxis Oncology seller in Q1 2025 was Jacobs Levy Equity Management, an estimated $939K sold.

Based on aggregated 13F filings for Q1 2025.