Personalis
PSNL
126 hedge funds and large institutions have $645M invested in Personalis in 2025 Q4 according to their latest regulatory filings, with 31 funds opening new positions, 37 increasing their positions, 38 reducing their positions, and 14 closing their positions.
121% more first-time investments, than exits
New positions opened: 31 | Existing positions closed: 14
53% more capital invested
Capital invested by funds: $422M → $645M (+$223M)
20% more funds holding in top 10
Funds holding in top 10: 5 → 6 (+1)
18.25% more ownership
Funds ownership: 72.96% → 91.21% (+18%)
16% more funds holding
Funds holding: 109 → 126 (+17)
3% less repeat investments, than reductions
Existing positions increased: 37 | Existing positions reduced: 38
9% less call options, than puts
Call options by funds: $833K | Put options by funds: $915K
Top Buyers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
T. Rowe Price Investment Management
Baltimore,
Maryland
|
+$69.1M |
| 2 |
Ameriprise
Minneapolis,
Minnesota
|
+$52.4M |
| 3 |
T. Rowe Price Associates
Baltimore,
Maryland
|
+$11.8M |
| 4 |
Aberdeen Group
Edinburgh,
United Kingdom
|
+$7.54M |
| 5 |
PHS
PFM Health Sciences
San Francisco,
California
|
+$7.05M |
Top Sellers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
ACM
AIGH Capital Management
Baltimore,
Maryland
|
-$8.68M |
| 2 |
Millennium Management
New York
|
-$7.89M |
| 3 |
Renaissance Technologies
New York
|
-$3.15M |
| 4 |
BlackRock
New York
|
-$2.85M |
| 5 |
Goldman Sachs
New York
|
-$2.02M |
PSNL Hedge Fund Activity: Q4 2025 in Review
126 of the 8,270 institutional investors tracked by Wall St. Rank reported a position in Personalis (PSNL) for Q4 2025, worth a combined $645M — up 53% from $422M a quarter earlier.
Buyers outnumbered sellers: 31 funds opened new PSNL positions and 14 closed out — a net gain of 17 holders — while 37 added to existing stakes and 38 trimmed.
The largest buyer was T. Rowe Price Investment Management, adding an estimated $69.1M. The largest seller was AIGH Capital Management, cutting an estimated $8.68M.
- 126 institutional investors held Personalis (PSNL) as of Q4 2025, up from 109 in Q3 2025.
- Funds reported $645M of Personalis stock for Q4 2025, up 53% quarter-over-quarter.
- 31 funds opened new Personalis positions in Q4 2025 and 14 closed out, a net change of +17 holders.
- The largest Personalis buyer in Q4 2025 was T. Rowe Price Investment Management, an estimated $69.1M added.
- The largest Personalis seller in Q4 2025 was AIGH Capital Management, an estimated $8.68M sold.
Based on aggregated 13F filings for Q4 2025.