Personalis
PSNL
140 hedge funds and large institutions have $540M invested in Personalis in 2026 Q1 according to their latest regulatory filings, with 36 funds opening new positions, 47 increasing their positions, 36 reducing their positions, and 20 closing their positions.
80% more first-time investments, than exits
New positions opened: 36 | Existing positions closed: 20
34% more call options, than puts
Call options by funds: $611K | Put options by funds: $457K
31% more repeat investments, than reductions
Existing positions increased: 47 | Existing positions reduced: 36
11% more funds holding
Funds holding: 126 → 140 (+14)
10.34% less ownership
Funds ownership: 91.21% → 80.87% (-10%)
16% less capital invested
Capital invested by funds: $645M → $540M (-$104M)
33% less funds holding in top 10
Funds holding in top 10: 6 → 4 (-2)
Top Buyers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
DTC
Deep Track Capital
Greenwich,
Connecticut
|
+$25.3M |
| 2 |
CC
Casdin Capital
New York
|
+$13.5M |
| 3 |
Ameriprise
Minneapolis,
Minnesota
|
+$11M |
| 4 |
JP Morgan Chase
New York
|
+$4.63M |
| 5 |
KCM
Kennedy Capital Management
St Louis,
Missouri
|
+$3.98M |
Top Sellers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
T. Rowe Price Investment Management
Baltimore,
Maryland
|
-$50.8M |
| 2 |
NCGI
Next Century Growth Investors
Plymouth,
Minnesota
|
-$4.97M |
| 3 |
Jane Street
New York
|
-$1.45M |
| 4 |
TD Asset Management
Toronto,
Ontario, Canada
|
-$1.4M |
| 5 |
First Manhattan
New York
|
-$1.21M |
| Name | Holding | Trade Value |
Shares Change |
Change in Stake |
|
|---|---|---|---|---|---|
151
Simplex Trading
Chicago,
Illinois
| – | -$92.2K | -10,923 | Closed |
|
|
DS
152
DRW Securities
Chicago,
Illinois
| – | -$83.4K | -10,483 | Closed |
|
153
HSBC Holdings
London,
United Kingdom
| – | -$84.1K | -10,474 | Closed |
|
|
A
154
AlphaQuest
New York
| – | -$39.9K | -5,007 | Closed |
|
|
AB
155
Amalgamated Bank
New York
| – | -$13K | -1,575 | Closed |
|
|
MA
156
MCF Advisors
Covington,
Kentucky
| – | -$6.37K | -800 | Closed |
|
157
Daiwa Securities Group
Tokyo,
Japan
| – | -$2K | -200 | Closed |
|
|
S
158
SignatureFD
Atlanta,
Georgia
| – | -$454 | -57 | Closed |
|
159
Rockefeller Capital Management
New York
| – | -$287 | -36 | Closed |
|
|
AAP
160
Arax Advisory Partners
Denver,
Colorado
| – | -$72 | -9 | Closed |
|
PSNL Hedge Fund Activity: Q1 2026 in Review
140 of the 8,126 institutional investors tracked by Wall St. Rank reported a position in Personalis (PSNL) for Q1 2026, worth a combined $540M — down 16% from $645M a quarter earlier.
Buyers outnumbered sellers: 36 funds opened new PSNL positions and 20 closed out — a net gain of 16 holders — while 47 added to existing stakes and 36 trimmed.
The largest buyer was Deep Track Capital, opening a new position worth an estimated $25.3M. The largest seller was T. Rowe Price Investment Management, cutting an estimated $50.8M.
- 140 institutional investors held Personalis (PSNL) as of Q1 2026, up from 126 in Q4 2025.
- Funds reported $540M of Personalis stock for Q1 2026, down 16% quarter-over-quarter.
- 36 funds opened new Personalis positions in Q1 2026 and 20 closed out, a net change of +16 holders.
- The largest Personalis buyer in Q1 2026 was Deep Track Capital, an estimated $25.3M added.
- The largest Personalis seller in Q1 2026 was T. Rowe Price Investment Management, an estimated $50.8M sold.
Based on aggregated 13F filings for Q1 2026.