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Personalis
PSNL

140 hedge funds and large institutions have $540M invested in Personalis in 2026 Q1 according to their latest regulatory filings, with 36 funds opening new positions, 47 increasing their positions, 36 reducing their positions, and 20 closing their positions.

New
Increased
Maintained
Reduced
Closed

80% more first-time investments, than exits

New positions opened: 36 | Existing positions closed: 20

34% more call options, than puts

Call options by funds: $611K | Put options by funds: $457K

31% more repeat investments, than reductions

Existing positions increased: 47 | Existing positions reduced: 36

11% more funds holding

Funds holding: 126 → 140 (+14)

10.34% less ownership

Funds ownership: 91.21% → 80.87% (-10%)

16% less capital invested

Capital invested by funds: $645M → $540M (-$104M)

33% less funds holding in top 10

Funds holding in top 10: 6 → 4 (-2)

Holders
140
Holders Change
+14
Holders Change %
+11.11%
% of All Funds
1.72%
Holding in Top 10
4
Holding in Top 10 Change
-2
Holding in Top 10 Change %
-33.33%
% of All Funds
0.05%
New
36
Increased
47
Reduced
36
Closed
20
Calls
$611K
Puts
$457K
Net Calls
+$154K
Net Calls Change
+$236K

Top Buyers

Rank Fund Capital Flow
1
DTC
Deep Track Capital
Connecticut
+$25.3M
2
CC
Casdin Capital
New York
+$13.5M
3
Ameriprise
Ameriprise
Minnesota
+$11M
4
JP Morgan Chase
JP Morgan Chase
New York
+$4.63M
5
KCM
Kennedy Capital Management
Missouri
+$3.98M

Top Sellers

Rank Fund Capital Flow
1
T. Rowe Price Investment Management
T. Rowe Price Investment Management
Maryland
-$50.8M
2
NCGI
Next Century Growth Investors
Minnesota
-$4.97M
3
Jane Street
Jane Street
New York
-$1.45M
4
TD Asset Management
TD Asset Management
Ontario, Canada
-$1.4M
5
First Manhattan
First Manhattan
New York
-$1.21M
Name Holding Trade Value Shares
Change 		Change in
Stake
NAMA
26
Nikko Asset Management Americas
New York
$3.08M -$288K -34,171 -7%
Millennium Management
27
Millennium Management
New York
$2.67M +$3.54M +419,128 New
Northern Trust
28
Northern Trust
Illinois
$2.58M +$430K +50,882 +14%
UBS Group
29
UBS Group
Switzerland
$2.44M +$649K +76,935 +25%
N
30
Nuveen
North Carolina
$2.19M +$294K +34,840 +11%
WSCM
31
Wellington Shields Capital Management
New York
$2.16M -$2.25K -267 -0.1%
VFT
32
Vanguard Fiduciary Trust
Pennsylvania
$2.16M +$2.87M +339,508 New
IEFM
33
IQ EQ Fund Management
Ireland
$2.06M +$470K +55,700 +21%
Balyasny Asset Management
34
Balyasny Asset Management
Illinois
$1.97M +$2.61M +308,696 New
Adage Capital Partners
35
Adage Capital Partners
Massachusetts
$1.91M +$2.53M +300,000 New
WSC
36
Wellington Shields & Co
New York
$1.86M – – –
SLAM
37
Swiss Life Asset Management
$1.59M +$254K +30,116 New
PCM
38
Perkins Capital Management
Minnesota
$1.52M – – –
Morgan Stanley
39
Morgan Stanley
New York
$1.51M +$108K +12,752 +6%
NCNMGF
40
Nano-Cap New Millennium Growth Fund
New York
$1.5M -$464K -55,000 -19%
BC
41
Bruce & Co
Illinois
$1.48M – – –
First Manhattan
42
First Manhattan
New York
$1.47M -$1.21M -143,222 -38%
Tudor Investment Corp
43
Tudor Investment Corp
Connecticut
$1.34M +$1.77M +209,826 New
HF
44
HRT Financial
New York
$1.33M +$938K +111,119 +114%
RA
45
Royce & Associates
New York
$994K +$1.32M +156,036 New
Susquehanna International Group
46
Susquehanna International Group
Pennsylvania
$951K +$999K +118,369 +382%
Charles Schwab
47
Charles Schwab
California
$921K -$114K -13,544 -9%
SEI Investments
48
SEI Investments
Pennsylvania
$886K +$701K +83,040 +148%
WJWM
49
Williams Jones Wealth Management
New York
$854K – – –
LPL Financial
50
LPL Financial
California
$841K -$2.79K -331 -0.3%
1
2
3 4 5

PSNL Hedge Fund Activity: Q1 2026 in Review

140 of the 8,126 institutional investors tracked by Wall St. Rank reported a position in Personalis (PSNL) for Q1 2026, worth a combined $540M — down 16% from $645M a quarter earlier.

Buyers outnumbered sellers: 36 funds opened new PSNL positions and 20 closed out — a net gain of 16 holders — while 47 added to existing stakes and 36 trimmed.

The largest buyer was Deep Track Capital, opening a new position worth an estimated $25.3M. The largest seller was T. Rowe Price Investment Management, cutting an estimated $50.8M.

  • 140 institutional investors held Personalis (PSNL) as of Q1 2026, up from 126 in Q4 2025.
  • Funds reported $540M of Personalis stock for Q1 2026, down 16% quarter-over-quarter.
  • 36 funds opened new Personalis positions in Q1 2026 and 20 closed out, a net change of +16 holders.
  • The largest Personalis buyer in Q1 2026 was Deep Track Capital, an estimated $25.3M added.
  • The largest Personalis seller in Q1 2026 was T. Rowe Price Investment Management, an estimated $50.8M sold.

Based on aggregated 13F filings for Q1 2026.