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Personalis
PSNL

126 hedge funds and large institutions have $645M invested in Personalis in 2025 Q4 according to their latest regulatory filings, with 31 funds opening new positions, 37 increasing their positions, 38 reducing their positions, and 14 closing their positions.

New
Increased
Maintained
Reduced
Closed

121% more first-time investments, than exits

New positions opened: 31 | Existing positions closed: 14

53% more capital invested

Capital invested by funds: $422M → $645M (+$223M)

20% more funds holding in top 10

Funds holding in top 10: 5 → 6 (+1)

18.25% more ownership

Funds ownership: 72.96% → 91.21% (+18%)

16% more funds holding

Funds holding: 109 → 126 (+17)

3% less repeat investments, than reductions

Existing positions increased: 37 | Existing positions reduced: 38

9% less call options, than puts

Call options by funds: $833K | Put options by funds: $915K

Holders
126
Holders Change
+17
Holders Change %
+15.6%
% of All Funds
1.53%
Holding in Top 10
6
Holding in Top 10 Change
+1
Holding in Top 10 Change %
+20%
% of All Funds
0.07%
New
31
Increased
37
Reduced
38
Closed
14
Calls
$833K
Puts
$915K
Net Calls
-$82K
Net Calls Change
+$372K

Top Buyers

Rank Fund Capital Flow
1
T. Rowe Price Investment Management
T. Rowe Price Investment Management
Maryland
+$69.1M
2
Ameriprise
Ameriprise
Minnesota
+$52.4M
3
T. Rowe Price Associates
T. Rowe Price Associates
Maryland
+$11.8M
4
Aberdeen Group
Aberdeen Group
United Kingdom
+$7.54M
5
PHS
PFM Health Sciences
California
+$7.05M

Top Sellers

Rank Fund Capital Flow
1
ACM
AIGH Capital Management
Maryland
-$8.68M
2
Millennium Management
Millennium Management
New York
-$7.89M
3
Renaissance Technologies
Renaissance Technologies
New York
-$3.15M
4
BlackRock
BlackRock
New York
-$2.85M
5
Goldman Sachs
Goldman Sachs
New York
-$2.02M
Name Holding Trade Value Shares
Change 		Change in
Stake
WSCM
26
Wellington Shields Capital Management
New York
$2.71M +$419K +47,865 +16%
OIM
27
Oracle Investment Management
Connecticut
$2.7M +$961K +109,908 +48%
N
28
Nuveen
North Carolina
$2.46M – – –
UBS Group
29
UBS Group
Switzerland
$2.44M +$96.2K +11,004 +4%
WSC
30
Wellington Shields & Co
New York
$2.33M – – –
NCNMGF
31
Nano-Cap New Millennium Growth Fund
New York
$2.31M +$2.54M +290,000 New
TD Asset Management
32
TD Asset Management
Ontario, Canada
$2.16M +$1.9M +217,292 +398%
IEFM
33
IQ EQ Fund Management
Ireland
$2.13M +$723K +82,638 +45%
PCM
34
Perkins Capital Management
Minnesota
$1.9M -$118K -13,500 -5%
BC
35
Bruce & Co
Illinois
$1.85M -$175K -20,000 -8%
Morgan Stanley
36
Morgan Stanley
New York
$1.79M -$1.03M -117,492 -34%
Jane Street
37
Jane Street
New York
$1.36M +$1.5M +171,166 New
Charles Schwab
38
Charles Schwab
California
$1.26M +$245 +28 +0%
DADC
39
D.A. Davidson & Co
Montana
$1.16M +$1.27M +145,507 New
WJWM
40
Williams Jones Wealth Management
New York
$1.07M – – –
LPL Financial
41
LPL Financial
California
$1.05M -$15.3K -1,749 -1%
Bank of New York Mellon
42
Bank of New York Mellon
New York
$979K -$20.7K -2,361 -2%
Barclays
43
Barclays
United Kingdom
$955K +$45K +5,148 +4%
American Century Companies
44
American Century Companies
Missouri
$907K +$17.4K +1,991 +2%
SFI
45
Susquehanna Fundamental Investments
Pennsylvania
$867K – – –
HF
46
HRT Financial
New York
$778K +$855K +97,772 New
Renaissance Technologies
47
Renaissance Technologies
New York
$740K -$3.15M -360,049 -79%
Citadel Advisors
48
Citadel Advisors
Florida
$734K +$806K +92,162 New
Royal Bank of Canada
49
Royal Bank of Canada
Ontario, Canada
$631K -$657K -75,067 -49%
GAA
50
Green Alpha Advisors
Colorado
$545K +$351K +40,126 +141%
1
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3 4 5

PSNL Hedge Fund Activity: Q4 2025 in Review

126 of the 8,223 institutional investors tracked by Wall St. Rank reported a position in Personalis (PSNL) for Q4 2025, worth a combined $645M — up 53% from $422M a quarter earlier.

Buyers outnumbered sellers: 31 funds opened new PSNL positions and 14 closed out — a net gain of 17 holders — while 37 added to existing stakes and 38 trimmed.

The largest buyer was T. Rowe Price Investment Management, adding an estimated $69.1M. The largest seller was AIGH Capital Management, cutting an estimated $8.68M.

  • 126 institutional investors held Personalis (PSNL) as of Q4 2025, up from 109 in Q3 2025.
  • Funds reported $645M of Personalis stock for Q4 2025, up 53% quarter-over-quarter.
  • 31 funds opened new Personalis positions in Q4 2025 and 14 closed out, a net change of +17 holders.
  • The largest Personalis buyer in Q4 2025 was T. Rowe Price Investment Management, an estimated $69.1M added.
  • The largest Personalis seller in Q4 2025 was AIGH Capital Management, an estimated $8.68M sold.

Based on aggregated 13F filings for Q4 2025.