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PepGen
PEPG

87 hedge funds and large institutions have $373M invested in PepGen in 2025 Q4 according to their latest regulatory filings, with 29 funds opening new positions, 27 increasing their positions, 17 reducing their positions, and 12 closing their positions.

New
Increased
Maintained
Reduced
Closed

200% more call options, than puts

Call options by funds: $5.31M | Put options by funds: $1.77M

142% more first-time investments, than exits

New positions opened: 29 | Existing positions closed: 12

59% more repeat investments, than reductions

Existing positions increased: 27 | Existing positions reduced: 17

43% more capital invested

Capital invested by funds: $262M → $373M (+$111M)

21% more funds holding

Funds holding: 72 → 87 (+15)

89.51% less ownership

Funds ownership: 172.95% → 83.44% (-90%)

Holders
87
Holders Change
+15
Holders Change %
+20.83%
% of All Funds
1.06%
Holding in Top 10
–
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
–
New
29
Increased
27
Reduced
17
Closed
12
Calls
$5.31M
Puts
$1.77M
Net Calls
+$3.54M
Net Calls Change
-$1.51M

Top Buyers

Rank Fund Capital Flow
1
NCM
Nantahala Capital Management
Connecticut
+$8.03M
2
CC
Commodore Capital
New York
+$5.41M
3
Pictet Asset Management
Pictet Asset Management
Switzerland
+$4.52M
4
BlackRock
BlackRock
New York
+$4.07M
5
Morgan Stanley
Morgan Stanley
New York
+$2.64M

Top Sellers

Rank Fund Capital Flow
1
Adage Capital Partners
Adage Capital Partners
Massachusetts
-$7.01M
2
RI
RTW Investments
New York
-$6.93M
3
DTC
Deep Track Capital
Connecticut
-$5.54M
4
TCM
TCG Crossover Management
California
-$5.54M
5
EC
EcoR1 Capital
California
-$3.7M
Name Holding Trade Value Shares
Change 		Change in
Stake
RCM
1
RA Capital Management
Massachusetts
$131M – – –
Viking Global Investors
2
Viking Global Investors
Connecticut
$22.7M – – –
CC
3
Commodore Capital
New York
$22.1M +$5.41M +1,042,681 +44%
VC
4
Vivo Capital
California
$15.1M – – –
Point72 Asset Management
5
Point72 Asset Management
Connecticut
$14.8M +$1.27M +244,416 +12%
Vanguard Group
6
Vanguard Group
Pennsylvania
$14.4M +$2.31M +444,478 +25%
LCM
7
Laurion Capital Management
New York
$13.4M +$830K +159,977 +8%
BI
8
BVF Inc
California
$12.5M – – –
NCM
9
Nantahala Capital Management
Connecticut
$10.1M +$8.03M +1,547,229 New
Janus Henderson Group
10
Janus Henderson Group
United Kingdom
$9.79M – – –
Pictet Asset Management
11
Pictet Asset Management
Switzerland
$8.8M +$4.52M +871,059 +181%
WP
12
Woodline Partners
California
$8.53M – – –
AIC
13
AWM Investment Company
New York
$8.46M +$1.43M +275,000 +27%
BlackRock
14
BlackRock
New York
$8.04M +$4.07M +784,288 +174%
Morgan Stanley
15
Morgan Stanley
New York
$7.06M +$2.64M +509,244 +89%
Balyasny Asset Management
16
Balyasny Asset Management
Illinois
$5.64M -$2.43M -467,314 -35%
PA
17
Perceptive Advisors
New York
$5.4M – – –
OCA
18
Octagon Capital Advisors
New York
$4.56M – – –
SL
19
Siren LLC
Connecticut
$4.56M – – –
Geode Capital Management
20
Geode Capital Management
Massachusetts
$3.53M +$1.77M +341,378 +170%
IC
21
Ikarian Capital
Texas
$2.91M -$461K -88,802 -17%
BFM
22
Boothbay Fund Management
New York
$2.72M +$351K +67,611 +19%
BCM
23
Boxer Capital Management
California
$2.43M +$643K +123,892 +50%
Bank of America
24
Bank of America
North Carolina
$2.29M +$1.81M +348,456 +12,978%
DCM
25
Driehaus Capital Management
Illinois
$2.05M – – –
1
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PEPG Hedge Fund Activity: Q4 2025 in Review

87 of the 8,226 institutional investors tracked by Wall St. Rank reported a position in PepGen (PEPG) for Q4 2025, worth a combined $373M — up 43% from $262M a quarter earlier.

Buyers outnumbered sellers: 29 funds opened new PEPG positions and 12 closed out — a net gain of 17 holders — while 27 added to existing stakes and 17 trimmed.

The largest buyer was Nantahala Capital Management, opening a new position worth an estimated $8.03M. The largest seller was Adage Capital Partners, cutting an estimated $7.01M.

  • 87 institutional investors held PepGen (PEPG) as of Q4 2025, up from 72 in Q3 2025.
  • Funds reported $373M of PepGen stock for Q4 2025, up 43% quarter-over-quarter.
  • 29 funds opened new PepGen positions in Q4 2025 and 12 closed out, a net change of +17 holders.
  • The largest PepGen buyer in Q4 2025 was Nantahala Capital Management, an estimated $8.03M added.
  • The largest PepGen seller in Q4 2025 was Adage Capital Partners, an estimated $7.01M sold.

Based on aggregated 13F filings for Q4 2025.