Omeros
OMER
149 hedge funds and large institutions have $582M invested in Omeros in 2025 Q4 according to their latest regulatory filings, with 33 funds opening new positions, 60 increasing their positions, 34 reducing their positions, and 15 closing their positions.
332% more capital invested
Capital invested by funds: $135M → $582M (+$447M)
120% more first-time investments, than exits
New positions opened: 33 | Existing positions closed: 15
76% more repeat investments, than reductions
Existing positions increased: 60 | Existing positions reduced: 34
20% more call options, than puts
Call options by funds: $77.2M | Put options by funds: $64.5M
12% more funds holding
Funds holding: 133 → 149 (+16)
0.44% less ownership
Funds ownership: 48.27% → 47.83% (-0.44%)
Top Buyers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
UBS Group
Zurich,
Switzerland
|
+$13M |
| 2 |
Corient Private Wealth
Miami,
Florida
|
+$6.6M |
| 3 |
Vanguard Group
Malvern,
Pennsylvania
|
+$5.74M |
| 4 |
Susquehanna International Group
Bala Cynwyd,
Pennsylvania
|
+$5.44M |
| 5 |
Nomura Holdings
Tokyo,
Japan
|
+$5.26M |
Top Sellers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
Morgan Stanley
New York
|
-$13.8M |
| 2 |
PAMP
Polar Asset Management Partners
Toronto,
Ontario, Canada
|
-$12.3M |
| 3 |
ISL
Ingalls & Snyder LLC
New York
|
-$5.67M |
| 4 |
Two Sigma Advisers
New York
|
-$4.32M |
| 5 |
Two Sigma Investments
New York
|
-$3.52M |
OMER Hedge Fund Activity: Q4 2025 in Review
149 of the 8,228 institutional investors tracked by Wall St. Rank reported a position in Omeros (OMER) for Q4 2025, worth a combined $582M — up 332% from $135M a quarter earlier.
Buyers outnumbered sellers: 33 funds opened new OMER positions and 15 closed out — a net gain of 18 holders — while 60 added to existing stakes and 34 trimmed.
The largest buyer was UBS Group, adding an estimated $13M. The largest seller was Morgan Stanley, cutting an estimated $13.8M.
- 149 institutional investors held Omeros (OMER) as of Q4 2025, up from 133 in Q3 2025.
- Funds reported $582M of Omeros stock for Q4 2025, up 332% quarter-over-quarter.
- 33 funds opened new Omeros positions in Q4 2025 and 15 closed out, a net change of +18 holders.
- The largest Omeros buyer in Q4 2025 was UBS Group, an estimated $13M added.
- The largest Omeros seller in Q4 2025 was Morgan Stanley, an estimated $13.8M sold.
Based on aggregated 13F filings for Q4 2025.