|
1
|
Deerfield Management
New York
|
$1.77B
|
–
|
–
|
–
|
|
|
2
|
Fidelity Investments
Boston,
Massachusetts
|
$950M
|
-$161M
|
-1,577,925
|
-15%
|
|
|
3
|
Paradigm Biocapital Advisors
New York
|
$545M
|
+$5.61M
|
+55,000
|
+1%
|
|
|
4
|
|
$494M
|
+$1.99M
|
+19,524
|
+0.4%
|
|
|
5
|
|
$299M
|
+$90M
|
+883,098
|
+40%
|
|
|
6
|
RA Capital Management
Boston,
Massachusetts
|
$260M
|
+$66.7M
|
+654,088
|
+35%
|
|
|
7
|
Vanguard Portfolio Management
Malvern,
Pennsylvania
|
$256M
|
+$255M
|
+2,500,907
|
New
|
|
|
8
|
Wellington Management Group
Boston,
Massachusetts
|
$253M
|
+$883K
|
+8,668
|
+0.4%
|
|
|
9
|
Vanguard Capital Management
Malvern,
Pennsylvania
|
$249M
|
+$247M
|
+2,428,488
|
New
|
|
|
10
|
T. Rowe Price Associates
Baltimore,
Maryland
|
$211M
|
-$9.25M
|
-90,805
|
-4%
|
|
|
11
|
State Street
Boston,
Massachusetts
|
$209M
|
+$17.4M
|
+171,156
|
+9%
|
|
|
12
|
Polar Capital Holdings
London,
United Kingdom
|
$188M
|
+$30M
|
+294,394
|
+19%
|
|
|
13
|
Perceptive Advisors
New York
|
$162M
|
-$8.62M
|
-84,600
|
-5%
|
|
|
14
|
T. Rowe Price Investment Management
Baltimore,
Maryland
|
$145M
|
+$9.55M
|
+93,674
|
+7%
|
|
|
15
|
Deep Track Capital
Greenwich,
Connecticut
|
$141M
|
+$140M
|
+1,376,324
|
New
|
|
|
16
|
Geode Capital Management
Boston,
Massachusetts
|
$133M
|
+$6.1M
|
+59,873
|
+5%
|
|
|
17
|
Janus Henderson Group
London,
|
$127M
|
-$26.7M
|
-261,795
|
-17%
|
|
|
18
|
Bellevue Group
Kuesnacht,
Switzerland
|
$108M
|
+$1.61M
|
+15,800
|
+2%
|
|
|
19
|
Commodore Capital
New York
|
$85.4M
|
+$28.9M
|
+283,600
|
+52%
|
|
|
20
|
AllianceBernstein
Nashville,
Tennessee
|
$78.9M
|
-$145K
|
-1,422
|
-0.2%
|
|
|
21
|
Adage Capital Partners
Boston,
Massachusetts
|
$76.7M
|
+$10.8M
|
+105,896
|
+16%
|
|
|
22
|
Braidwell
Stamford,
Connecticut
|
$71.8M
|
-$12.3M
|
-120,977
|
-15%
|
|
|
23
|
Woodline Partners
San Francisco,
California
|
$62.5M
|
–
|
–
|
–
|
|
|
24
|
Ameriprise
Minneapolis,
Minnesota
|
$57.8M
|
-$54K
|
-530
|
-0.1%
|
|
|
25
|
|
$55M
|
-$5.84M
|
-57,301
|
-10%
|
|
