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Nautilus Biotechnolgy

68 hedge funds and large institutions have $48.9M invested in Nautilus Biotechnolgy in 2025 Q3 according to their latest regulatory filings, with 9 funds opening new positions, 8 increasing their positions, 29 reducing their positions, and 12 closing their positions.

New
Increased
Maintained
Reduced
Closed

13% more capital invested

Capital invested by funds: $43.3M → $48.9M (+$5.6M)

0% more funds holding in top 10

Funds holding in top 10: 33 (0)

1.53% less ownership

Funds ownership: 47.37%45.84% (-1.5%)

4% less funds holding

Funds holding: 7168 (-3)

25% less first-time investments, than exits

New positions opened: 9 | Existing positions closed: 12

72% less repeat investments, than reductions

Existing positions increased: 8 | Existing positions reduced: 29

Holders
68
Holders Change
-3
Holders Change %
-4.23%
% of All Funds
0.89%
Holding in Top 10
3
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
0.04%
New
9
Increased
8
Reduced
29
Closed
12
Calls
Puts
Net Calls
Net Calls Change
Name Holding Trade Value Shares
Change
Change in
Stake
ACM
1
AH Capital Management
California
$14.9M
PA
2
Perceptive Advisors
New York
$10.6M
CM
3
Cercano Management
Washington
$6.06M
MVG
4
Madrona Venture Group
Washington
$5.09M
Vanguard Group
5
Vanguard Group
Pennsylvania
$2.05M -$39.1K -53,252 -2%
CFM
6
Comprehensive Financial Management
California
$1.87M
ACI
7
Amazon.com Inc
Washington
$1.23M
CGL
8
Clarius Group LLC
Washington
$1.02M +$110K +149,186 +14%
Renaissance Technologies
9
Renaissance Technologies
New York
$851K +$285K +387,756 +63%
Millennium Management
10
Millennium Management
New York
$817K -$65.6K -89,291 -8%
TM
11
Tikvah Management
North Carolina
$614K
Geode Capital Management
12
Geode Capital Management
Massachusetts
$468K
Dimensional Fund Advisors
13
Dimensional Fund Advisors
Texas
$308K -$137K -186,065 -34%
Corient Private Wealth
14
Corient Private Wealth
Florida
$270K -$85.4K -116,210 -27%
Jacobs Levy Equity Management
15
Jacobs Levy Equity Management
New Jersey
$254K +$33.9K +46,153 +18%
GCP
16
GSA Capital Partners
United Kingdom
$219K +$60.5K +82,295 +47%
Citadel Advisors
17
Citadel Advisors
Florida
$215K +$55.9K +76,006 +43%
Alyeska Investment Group
18
Alyeska Investment Group
Illinois
$214K
Acadian Asset Management
19
Acadian Asset Management
Massachusetts
$203K +$128K +174,065 +252%
BlackRock
20
BlackRock
New York
$170K -$314K -427,457 -68%
HC
21
Hillman Company
Pennsylvania
$169K
State Street
22
State Street
Massachusetts
$151K -$2.1K -2,861 -2%
Jane Street
23
Jane Street
New York
$125K -$104K -142,181 -49%
CA
24
Crewe Advisors
Utah
$115K +$100K +136,052 New
Squarepoint
25
Squarepoint
New York
$111K +$22.1K +30,005 +29%

NAUT Hedge Fund Activity: Q3 2025 in Review

68 of the 7,621 institutional investors tracked by Wall St. Rank reported a position in Nautilus Biotechnolgy (NAUT) for Q3 2025, worth a combined $48.9M — up 13% from $43.3M a quarter earlier.

Sellers outnumbered buyers: 12 funds closed out of NAUT and 9 opened new positions — a net loss of 3 holders — while 29 trimmed existing stakes and 8 added.

The largest buyer was Renaissance Technologies, adding an estimated $285K. The largest seller was ArchPoint Investors, exiting entirely with an estimated $451K sold.

  • 68 institutional investors held Nautilus Biotechnolgy (NAUT) as of Q3 2025, down from 71 in Q2 2025.
  • Funds reported $48.9M of Nautilus Biotechnolgy stock for Q3 2025, up 13% quarter-over-quarter.
  • 9 funds opened new Nautilus Biotechnolgy positions in Q3 2025 and 12 closed out, a net change of -3 holders.
  • The largest Nautilus Biotechnolgy buyer in Q3 2025 was Renaissance Technologies, an estimated $285K added.
  • The largest Nautilus Biotechnolgy seller in Q3 2025 was ArchPoint Investors, an estimated $451K sold.

Based on aggregated 13F filings for Q3 2025.