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Nautilus Biotechnolgy
NAUT

71 hedge funds and large institutions have $43.3M invested in Nautilus Biotechnolgy in 2025 Q2 according to their latest regulatory filings, with 12 funds opening new positions, 25 increasing their positions, 17 reducing their positions, and 28 closing their positions.

New
Increased
Maintained
Reduced
Closed

47% more repeat investments, than reductions

Existing positions increased: 25 | Existing positions reduced: 17

0% more funds holding in top 10

Funds holding in top 10: 3 → 3 (0)

2.39% less ownership

Funds ownership: 49.76% → 47.37% (-2.4%)

19% less funds holding

Funds holding: 88 → 71 (-17)

20% less capital invested

Capital invested by funds: $54M → $43.3M (-$10.7M)

57% less first-time investments, than exits

New positions opened: 12 | Existing positions closed: 28

Holders
71
Holders Change
-17
Holders Change %
-19.32%
% of All Funds
0.93%
Holding in Top 10
3
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.04%
New
12
Increased
25
Reduced
17
Closed
28
Calls
$115K
Puts
–
Net Calls
+$115K
Net Calls Change
+$95K

Top Buyers

Rank Fund Capital Flow
1
Millennium Management
Millennium Management
New York
+$727K
2
Corient Private Wealth
Corient Private Wealth
Florida
+$293K
3
Renaissance Technologies
Renaissance Technologies
New York
+$240K
4
YIH
Y-Intercept (HK)
Hong Kong
+$169K
5
Jane Street
Jane Street
New York
+$164K

Top Sellers

Rank Fund Capital Flow
1
BlackRock
BlackRock
New York
-$1.63M
2
BCLSI
Bain Capital Life Sciences Investors
Massachusetts
-$923K
3
State Street
State Street
Massachusetts
-$548K
4
Geode Capital Management
Geode Capital Management
Massachusetts
-$449K
5
Northern Trust
Northern Trust
Illinois
-$257K
Name Holding Trade Value Shares
Change 		Change in
Stake
ACM
1
AH Capital Management
California
$12.8M – – –
PA
2
Perceptive Advisors
New York
$9.13M – – –
CM
3
Cercano Management
Washington
$5.2M – – –
MVG
4
Madrona Venture Group
Washington
$4.36M – – –
Vanguard Group
5
Vanguard Group
Pennsylvania
$1.8M -$216K -287,627 -10%
CFM
6
Comprehensive Financial Management
California
$1.6M – – –
ACI
7
Amazon.com Inc
Washington
$1.06M – – –
CGL
8
Clarius Group LLC
Washington
$769K +$146K +193,874 +22%
Millennium Management
9
Millennium Management
New York
$766K +$727K +967,224 +1,079%
TM
10
Tikvah Management
North Carolina
$527K – – –
BlackRock
11
BlackRock
New York
$456K -$1.63M -2,169,762 -78%
AI
12
ArchPoint Investors
Florida
$451K +$12.2K +16,276 +3%
Renaissance Technologies
13
Renaissance Technologies
New York
$449K +$240K +319,450 +106%
Geode Capital Management
14
Geode Capital Management
Massachusetts
$401K -$449K -597,420 -52%
Dimensional Fund Advisors
15
Dimensional Fund Advisors
Texas
$399K -$82K -109,178 -17%
Corient Private Wealth
16
Corient Private Wealth
Florida
$316K +$293K +390,000 +860%
Goldman Sachs
17
Goldman Sachs
New York
$228K +$108K +143,151 +83%
Jane Street
18
Jane Street
New York
$210K +$164K +218,512 +304%
ST
19
Sentinel Trust
Texas
$203K – – –
Jacobs Levy Equity Management
20
Jacobs Levy Equity Management
New Jersey
$185K +$22.4K +29,761 +13%
Alyeska Investment Group
21
Alyeska Investment Group
Illinois
$184K – – –
YIH
22
Y-Intercept (HK)
Hong Kong
$163K +$169K +224,456 New
HC
23
Hillman Company
Pennsylvania
$145K – – –
State Street
24
State Street
Massachusetts
$132K -$548K -729,215 -80%
Citadel Advisors
25
Citadel Advisors
Florida
$129K +$56.5K +75,227 +73%
1
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NAUT Hedge Fund Activity: Q2 2025 in Review

71 of the 7,596 institutional investors tracked by Wall St. Rank reported a position in Nautilus Biotechnolgy (NAUT) for Q2 2025, worth a combined $43.3M — down 20% from $54M a quarter earlier.

Sellers outnumbered buyers: 28 funds closed out of NAUT and 12 opened new positions — a net loss of 16 holders — while 17 trimmed existing stakes and 25 added.

The largest buyer was Millennium Management, adding an estimated $727K. The largest seller was BlackRock, cutting an estimated $1.63M.

  • 71 institutional investors held Nautilus Biotechnolgy (NAUT) as of Q2 2025, down from 88 in Q1 2025.
  • Funds reported $43.3M of Nautilus Biotechnolgy stock for Q2 2025, down 20% quarter-over-quarter.
  • 12 funds opened new Nautilus Biotechnolgy positions in Q2 2025 and 28 closed out, a net change of -16 holders.
  • The largest Nautilus Biotechnolgy buyer in Q2 2025 was Millennium Management, an estimated $727K added.
  • The largest Nautilus Biotechnolgy seller in Q2 2025 was BlackRock, an estimated $1.63M sold.

Based on aggregated 13F filings for Q2 2025.