Mirum Pharmaceuticals
MIRM
282 hedge funds and large institutions have $4.82B invested in Mirum Pharmaceuticals in 2025 Q4 according to their latest regulatory filings, with 61 funds opening new positions, 103 increasing their positions, 79 reducing their positions, and 43 closing their positions.
122% more call options, than puts
Call options by funds: $4.55M | Put options by funds: $2.05M
42% more first-time investments, than exits
New positions opened: 61 | Existing positions closed: 43
30% more repeat investments, than reductions
Existing positions increased: 103 | Existing positions reduced: 79
15% more capital invested
Capital invested by funds: $4.2B → $4.82B (+$616M)
10% more funds holding in top 10
Funds holding in top 10: 10 → 11 (+1)
4.58% more ownership
Funds ownership: 114.15% → 118.73% (+4.6%)
4% more funds holding
Funds holding: 272 → 282 (+10)
Top Buyers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
Janus Henderson Group
London,
|
+$76.6M |
| 2 |
State Street
Boston,
Massachusetts
|
+$57.2M |
| 3 |
Wellington Management Group
Boston,
Massachusetts
|
+$32.1M |
| 4 |
SCM
Soleus Capital Management
Greenwich,
Connecticut
|
+$30.5M |
| 5 |
Bank of America
Charlotte,
North Carolina
|
+$23.2M |
Top Sellers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
Point72 Asset Management
Stamford,
Connecticut
|
-$43.1M |
| 2 |
EAM
Eventide Asset Management
Boston,
Massachusetts
|
-$30.8M |
| 3 |
Macquarie Group
Sydney, NSW 2000,
Australia
|
-$28.8M |
| 4 |
Jane Street
New York
|
-$18.3M |
| 5 |
Morgan Stanley
New York
|
-$17.5M |
MIRM Hedge Fund Activity: Q4 2025 in Review
282 of the 8,162 institutional investors tracked by Wall St. Rank reported a position in Mirum Pharmaceuticals (MIRM) for Q4 2025, worth a combined $4.82B — up 15% from $4.2B a quarter earlier.
Buyers outnumbered sellers: 61 funds opened new MIRM positions and 43 closed out — a net gain of 18 holders — while 103 added to existing stakes and 79 trimmed.
The largest buyer was Janus Henderson Group, adding an estimated $76.6M. The largest seller was Point72 Asset Management, cutting an estimated $43.1M.
- 282 institutional investors held Mirum Pharmaceuticals (MIRM) as of Q4 2025, up from 272 in Q3 2025.
- Funds reported $4.82B of Mirum Pharmaceuticals stock for Q4 2025, up 15% quarter-over-quarter.
- 61 funds opened new Mirum Pharmaceuticals positions in Q4 2025 and 43 closed out, a net change of +18 holders.
- The largest Mirum Pharmaceuticals buyer in Q4 2025 was Janus Henderson Group, an estimated $76.6M added.
- The largest Mirum Pharmaceuticals seller in Q4 2025 was Point72 Asset Management, an estimated $43.1M sold.
Based on aggregated 13F filings for Q4 2025.