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MacroGenics
MGNX

112 hedge funds and large institutions have $58.5M invested in MacroGenics in 2025 Q2 according to their latest regulatory filings, with 26 funds opening new positions, 26 increasing their positions, 35 reducing their positions, and 42 closing their positions.

New
Increased
Maintained
Reduced
Closed

66% more call options, than puts

Call options by funds: $83K | Put options by funds: $50K

8.72% less ownership

Funds ownership: 85.32% → 76.6% (-8.7%)

13% less funds holding

Funds holding: 128 → 112 (-16)

14% less capital invested

Capital invested by funds: $68.3M → $58.5M (-$9.82M)

26% less repeat investments, than reductions

Existing positions increased: 26 | Existing positions reduced: 35

38% less first-time investments, than exits

New positions opened: 26 | Existing positions closed: 42

Holders
112
Holders Change
-16
Holders Change %
-12.5%
% of All Funds
1.47%
Holding in Top 10
–
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
–
New
26
Increased
26
Reduced
35
Closed
42
Calls
$83K
Puts
$50K
Net Calls
+$33K
Net Calls Change
+$149K

Top Buyers

Rank Fund Capital Flow
1
EC
EcoR1 Capital
California
+$2.32M
2
Jane Street
Jane Street
New York
+$742K
3
Goldman Sachs
Goldman Sachs
New York
+$726K
4
CSS
Cubist Systematic Strategies
Connecticut
+$511K
5
Jacobs Levy Equity Management
Jacobs Levy Equity Management
New Jersey
+$492K

Top Sellers

Rank Fund Capital Flow
1
BlackRock
BlackRock
New York
-$4.49M
2
State Street
State Street
Massachusetts
-$1.61M
3
RSCM
Rock Springs Capital Management
Maryland
-$1.45M
4
Geode Capital Management
Geode Capital Management
Massachusetts
-$1.12M
5
GCP
GSA Capital Partners
United Kingdom
-$570K
Name Holding Trade Value Shares
Change 		Change in
Stake
BG
1
Bellevue Group
Switzerland
$12M -$14.5K -9,971 -0.1%
AC
2
Armistice Capital
New York
$7.21M -$487K -336,000 -5%
Vanguard Group
3
Vanguard Group
Pennsylvania
$5.1M -$309K -212,878 -5%
WA
4
Wasatch Advisors
Utah
$3.93M +$1.12K +774 +0%
FLSM
5
Frazier Life Sciences Management
California
$3.84M – – –
Acadian Asset Management
6
Acadian Asset Management
Massachusetts
$3.01M +$266K +183,054 +8%
Millennium Management
7
Millennium Management
New York
$2.44M +$423K +291,614 +17%
BlackRock
8
BlackRock
New York
$2.2M -$4.49M -3,095,599 -63%
EC
9
EcoR1 Capital
California
$1.94M +$2.32M +1,602,717 New
Renaissance Technologies
10
Renaissance Technologies
New York
$1.61M +$253K +174,224 +15%
Jacobs Levy Equity Management
11
Jacobs Levy Equity Management
New Jersey
$1.22M +$492K +339,447 +51%
Two Sigma Advisers
12
Two Sigma Advisers
New York
$1.04M -$306K -211,100 -20%
Jane Street
13
Jane Street
New York
$917K +$742K +511,777 +208%
Goldman Sachs
14
Goldman Sachs
New York
$845K +$726K +500,592 +253%
Geode Capital Management
15
Geode Capital Management
Massachusetts
$827K -$1.12M -772,650 -53%
Connor, Clark & Lunn Investment Management (CC&L)
16
Connor, Clark & Lunn Investment Management (CC&L)
British Columbia, Canada
$826K -$194K -133,777 -16%
Dimensional Fund Advisors
17
Dimensional Fund Advisors
Texas
$616K -$198K -136,822 -21%
JP Morgan Chase
18
JP Morgan Chase
New York
$557K -$413K -284,925 -38%
Morgan Stanley
19
Morgan Stanley
New York
$540K +$152K +104,737 +31%
Macquarie Group
20
Macquarie Group
Australia
$508K – – –
Two Sigma Investments
21
Two Sigma Investments
New York
$493K -$359K -247,610 -38%
Marshall Wace
22
Marshall Wace
United Kingdom
$491K +$155K +106,883 +36%
CSS
23
Cubist Systematic Strategies
Connecticut
$426K +$511K +352,105 New
PA
24
Pinnacle Associates
New York
$425K -$182K -125,529 -26%
Charles Schwab
25
Charles Schwab
California
$405K -$277K -191,186 -36%
1
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MGNX Hedge Fund Activity: Q2 2025 in Review

112 of the 7,596 institutional investors tracked by Wall St. Rank reported a position in MacroGenics (MGNX) for Q2 2025, worth a combined $58.5M — down 14% from $68.3M a quarter earlier.

Sellers outnumbered buyers: 42 funds closed out of MGNX and 26 opened new positions — a net loss of 16 holders — while 35 trimmed existing stakes and 26 added.

The largest buyer was EcoR1 Capital, opening a new position worth an estimated $2.32M. The largest seller was BlackRock, cutting an estimated $4.49M.

  • 112 institutional investors held MacroGenics (MGNX) as of Q2 2025, down from 128 in Q1 2025.
  • Funds reported $58.5M of MacroGenics stock for Q2 2025, down 14% quarter-over-quarter.
  • 26 funds opened new MacroGenics positions in Q2 2025 and 42 closed out, a net change of -16 holders.
  • The largest MacroGenics buyer in Q2 2025 was EcoR1 Capital, an estimated $2.32M added.
  • The largest MacroGenics seller in Q2 2025 was BlackRock, an estimated $4.49M sold.

Based on aggregated 13F filings for Q2 2025.