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Madrigal Pharmaceuticals

387 hedge funds and large institutions have $13.7B invested in Madrigal Pharmaceuticals in 2025 Q4 according to their latest regulatory filings, with 85 funds opening new positions, 137 increasing their positions, 113 reducing their positions, and 41 closing their positions.

New
Increased
Maintained
Reduced
Closed

107% more first-time investments, than exits

New positions opened: 85 | Existing positions closed: 41

28% more capital invested

Capital invested by funds: $10.7B → $13.7B (+$2.99B)

21% more repeat investments, than reductions

Existing positions increased: 137 | Existing positions reduced: 113

19% more call options, than puts

Call options by funds: $323M | Put options by funds: $271M

10% more funds holding

Funds holding: 352387 (+35)

1.57% less ownership

Funds ownership: 105.34%103.78% (-1.6%)

7% less funds holding in top 10

Funds holding in top 10: 1413 (-1)

Holders
387
Holders Change
+35
Holders Change %
+9.94%
% of All Funds
4.71%
Holding in Top 10
13
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-7.14%
% of All Funds
0.16%
New
85
Increased
137
Reduced
113
Closed
41
Calls
$323M
Puts
$271M
Net Calls
+$52.6M
Net Calls Change
-$16.2M
Name Holding Trade Value Shares
Change
Change in
Stake
American Century Companies
26
American Century Companies
Missouri
$108M +$9.96M +19,501 +12%
Pictet Asset Management
27
Pictet Asset Management
Switzerland
$106M -$5.03M -9,847 -5%
Fiera Capital (Canada)
28
Fiera Capital (Canada)
Quebec, Canada
$98.7M +$21.3M +41,656 +33%
Northern Trust
29
Northern Trust
Illinois
$88.4M -$4.18M -8,186 -5%
Morgan Stanley
30
Morgan Stanley
New York
$87.6M -$50.7M -99,185 -40%
EAM
31
Erste Asset Management
Austria
$82.3M -$30.6M -60,000 -30%
RSCM
32
Rock Springs Capital Management
Maryland
$81.3M +$956K +1,872 +1%
Bank of New York Mellon
33
Bank of New York Mellon
New York
$79.7M +$20M +39,090 +40%
Point72 Asset Management
34
Point72 Asset Management
Connecticut
$73.6M +$43.5M +85,202 +207%
WP
35
Woodline Partners
California
$73.2M +$11.1M +21,812 +21%
N
36
Nuveen
North Carolina
$68.9M +$22.8M +44,648 +61%
DCM
37
Driehaus Capital Management
Illinois
$65M -$2.2M -4,308 -4%
UBS Group
38
UBS Group
Switzerland
$59.8M -$58.6M -114,702 -53%
MB
39
MPM BioImpact
Massachusetts
$56.4M -$1.86M -3,635 -4%
Jane Street
40
Jane Street
New York
$54.2M -$1.34M -2,620 -3%
D.E. Shaw & Co
41
D.E. Shaw & Co
New York
$51.6M -$3.9M -7,628 -8%
Franklin Resources
42
Franklin Resources
California
$50.1M +$5.37M +10,506 +14%
TLP
43
Tri Locum Partners
New York
$50.1M +$9.36M +18,317 +27%
Renaissance Technologies
44
Renaissance Technologies
New York
$48.8M -$18.8M -36,820 -31%
ACH
45
ArrowMark Colorado Holdings
Colorado
$48.1M -$20.8M -40,635 -33%
New York State Common Retirement Fund
46
New York State Common Retirement Fund
New York
$44.2M +$3.4M +6,660 +10%
Squarepoint
47
Squarepoint
New York
$43.6M +$23M +44,998 +150%
BNP Paribas Financial Markets
48
BNP Paribas Financial Markets
France
$42.9M +$1.51M +2,950 +4%
FLAM
49
First Light Asset Management
Minnesota
$38.9M +$28.2M +55,292 +479%
Raymond James Financial
50
Raymond James Financial
Florida
$38.9M -$1.97M -3,860 -5%