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Kymera Therapeutics
KYMR

210 hedge funds and large institutions have $3.44B invested in Kymera Therapeutics in 2025 Q2 according to their latest regulatory filings, with 64 funds opening new positions, 69 increasing their positions, 52 reducing their positions, and 26 closing their positions.

New
Increased
Maintained
Reduced
Closed

219% more call options, than puts

Call options by funds: $10.1M | Put options by funds: $3.16M

146% more first-time investments, than exits

New positions opened: 64 | Existing positions closed: 26

72% more capital invested

Capital invested by funds: $2B → $3.44B (+$1.44B)

44% more funds holding in top 10

Funds holding in top 10: 9 → 13 (+4)

33% more repeat investments, than reductions

Existing positions increased: 69 | Existing positions reduced: 52

21% more funds holding

Funds holding: 173 → 210 (+37)

8.82% more ownership

Funds ownership: 112.19% → 121.01% (+8.8%)

Holders
210
Holders Change
+37
Holders Change %
+21.39%
% of All Funds
2.76%
Holding in Top 10
13
Holding in Top 10 Change
+4
Holding in Top 10 Change %
+44.44%
% of All Funds
0.17%
New
64
Increased
69
Reduced
52
Closed
26
Calls
$10.1M
Puts
$3.16M
Net Calls
+$6.93M
Net Calls Change
+$5.69M

Top Buyers

Rank Fund Capital Flow
1
Fidelity Investments
Fidelity Investments
Massachusetts
+$35.2M
2
Capital Research Global Investors
Capital Research Global Investors
California
+$30.9M
3
CC
Commodore Capital
New York
+$25.8M
4
BBA
Baker Bros. Advisors
New York
+$22.6M
5
Citadel Advisors
Citadel Advisors
Florida
+$17.8M

Top Sellers

Rank Fund Capital Flow
1
Janus Henderson Group
Janus Henderson Group
United Kingdom
-$25.9M
2
Wellington Management Group
Wellington Management Group
Massachusetts
-$21.5M
3
Millennium Management
Millennium Management
New York
-$15.6M
4
RSCM
Rock Springs Capital Management
Maryland
-$11.8M
5
DCM
Driehaus Capital Management
Illinois
-$8.09M
Name Holding Trade Value Shares
Change 		Change in
Stake
SO
201
Sierra Ocean
California
$1.22K – – –
GWM
202
Geneos Wealth Management
Colorado
$1.14K – – –
BFS
203
Bare Financial Services
Pennsylvania
$916 +$723 +21 New
PA
204
Parallel Advisors
California
$873 -$275 -8 -29%
FFO
205
Fortitude Family Office
Arizona
$786 +$620 +18 New
AssetMark Inc
206
AssetMark Inc
California
$262 +$207 +6 New
PS
207
Principal Securities
Iowa
$218 +$172 +5 New
RWM
208
Rialto Wealth Management
New York
$44 +$34 +1 New
SIC
209
SJS Investment Consulting
Ohio
$44 +$34 +1 New
ACM
210
Aquilo Capital Management
California
– -$3.79M -138,521 Closed
AAA
211
Affinity Asset Advisors
New York
– -$2.74M -100,000 Closed
First Trust Advisors
212
First Trust Advisors
Illinois
– -$2.57M -93,795 Closed
EFM
213
E Fund Management
China
– -$1.97M -71,863 Closed
Jane Street
214
Jane Street
New York
– -$2.25M -65,399 Closed
GCP
215
GSA Capital Partners
United Kingdom
– -$863K -31,537 Closed
CCM
216
Cinctive Capital Management
New York
– -$643K -23,492 Closed
CF
217
Corebridge Financial
Texas
– -$630K -23,002 Closed
Natixis Advisors
218
Natixis Advisors
Massachusetts
– -$392K -14,334 Closed
Walleye Capital
219
Walleye Capital
New York
– -$275K -10,059 Closed
HS
220
HighVista Strategies
Massachusetts
– -$239K -8,733 Closed
ETC
221
Exchange Traded Concepts
Oklahoma
– -$101K -3,693 Closed
CIAM
222
Caitong International Asset Management
Hong Kong
– -$67.5K -2,467 Closed
BTI
223
Blue Trust Inc
Georgia
– -$6.76K -247 Closed
CCM
224
Coldstream Capital Management
Washington
– -$4.87K -178 Closed
SSG
225
Summit Securities Group
New York
– -$3.83K -140 Closed
6 7 8
9
10

KYMR Hedge Fund Activity: Q2 2025 in Review

210 of the 7,596 institutional investors tracked by Wall St. Rank reported a position in Kymera Therapeutics (KYMR) for Q2 2025, worth a combined $3.44B — up 72% from $2B a quarter earlier.

Buyers outnumbered sellers: 64 funds opened new KYMR positions and 26 closed out — a net gain of 38 holders — while 69 added to existing stakes and 52 trimmed.

The largest buyer was Fidelity Investments, adding an estimated $35.2M. The largest seller was Janus Henderson Group, cutting an estimated $25.9M.

  • 210 institutional investors held Kymera Therapeutics (KYMR) as of Q2 2025, up from 173 in Q1 2025.
  • Funds reported $3.44B of Kymera Therapeutics stock for Q2 2025, up 72% quarter-over-quarter.
  • 64 funds opened new Kymera Therapeutics positions in Q2 2025 and 26 closed out, a net change of +38 holders.
  • The largest Kymera Therapeutics buyer in Q2 2025 was Fidelity Investments, an estimated $35.2M added.
  • The largest Kymera Therapeutics seller in Q2 2025 was Janus Henderson Group, an estimated $25.9M sold.

Based on aggregated 13F filings for Q2 2025.