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Kymera Therapeutics
KYMR

173 hedge funds and large institutions have $2B invested in Kymera Therapeutics in 2025 Q1 according to their latest regulatory filings, with 22 funds opening new positions, 64 increasing their positions, 58 reducing their positions, and 29 closing their positions.

New
Increased
Maintained
Reduced
Closed

19% more call options, than puts

Call options by funds: $7.84M | Put options by funds: $6.59M

10% more repeat investments, than reductions

Existing positions increased: 64 | Existing positions reduced: 58

1.46% more ownership

Funds ownership: 110.73% → 112.19% (+1.5%)

0% more funds holding in top 10

Funds holding in top 10: 9 → 9 (0)

4% less funds holding

Funds holding: 180 → 173 (-7)

24% less first-time investments, than exits

New positions opened: 22 | Existing positions closed: 29

31% less capital invested

Capital invested by funds: $2.89B → $2B (-$888M)

Holders
173
Holders Change
-7
Holders Change %
-3.89%
% of All Funds
2.32%
Holding in Top 10
9
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.12%
New
22
Increased
64
Reduced
58
Closed
29
Calls
$7.84M
Puts
$6.59M
Net Calls
+$1.24M
Net Calls Change
-$1.05M

Top Buyers

Rank Fund Capital Flow
1
ACA
Avoro Capital Advisors
New York
+$47.8M
2
Wellington Management Group
Wellington Management Group
Massachusetts
+$25.1M
3
UBS AM
UBS AM
Illinois
+$17.9M
4
Millennium Management
Millennium Management
New York
+$14.4M
5
Janus Henderson Group
Janus Henderson Group
United Kingdom
+$14.3M

Top Sellers

Rank Fund Capital Flow
1
APM
Avidity Partners Management
Texas
-$20.1M
2
FLAM
First Light Asset Management
Minnesota
-$15.4M
3
Fidelity Investments
Fidelity Investments
Massachusetts
-$15.4M
4
EC
EcoR1 Capital
California
-$14.1M
5
RSCM
Rock Springs Capital Management
Maryland
-$8.74M
Name Holding Trade Value Shares
Change 		Change in
Stake
EC
176
EcoR1 Capital
California
– -$14.1M -350,000 Closed
ACM
177
Atika Capital Management
New York
– -$5.49M -136,500 Closed
SFM
178
Soros Fund Management
New York
– -$4.84M -120,373 Closed
D.E. Shaw & Co
179
D.E. Shaw & Co
New York
– -$3.32M -82,578 Closed
SFI
180
Susquehanna Fundamental Investments
Pennsylvania
– -$2.39M -59,436 Closed
PBM
181
Propel Bio Management
California
– -$2.27M -56,359 Closed
SAM
182
Simplify Asset Management
Nevada
– -$1.23M -30,515 Closed
JG
183
Jain Global
New York
– -$1.06M -26,456 Closed
BAMCO Inc
184
BAMCO Inc
New York
– -$1.01M -25,000 Closed
ACM
185
Aquatic Capital Management
Illinois
– -$782K -19,431 Closed
CCIA
186
Campbell & Co Investment Adviser
Maryland
– -$745K -18,519 Closed
JF
187
Jump Financial
Illinois
– -$389K -9,666 Closed
Allianz Asset Management
188
Allianz Asset Management
Germany
– -$386K -9,600 Closed
SG Americas Securities
189
SG Americas Securities
New York
– -$323K -8,025 Closed
PEAK6
190
PEAK6
Illinois
– -$302K -7,500 Closed
NL
191
NVWM LLC
Pennsylvania
– -$289K -7,191 Closed
AQR Capital Management
192
AQR Capital Management
Connecticut
– -$265K -6,576 Closed
BAMF
193
BI Asset Management Fondsmaeglerselskab
Denmark
– -$251K -6,234 Closed
JGGDR
194
JGP Global Gestao de Recursos
Brazil
– -$241K -5,991 Closed
VA
195
Vident Advisory
Georgia
– -$236K -5,863 Closed
AIM
196
Aigen Investment Management
New York
– -$204K -5,069 Closed
SO
197
STRS Ohio
Ohio
– -$177K -4,400 Closed
VEA
198
Virtus ETF Advisers
New York
– -$67.8K -1,686 Closed
SOW
199
State of Wyoming
Wyoming
– -$45.1K -1,120 Closed
Creative Planning
200
Creative Planning
Kansas
– -$19.6K -487 Closed
5 6 7
8
9

KYMR Hedge Fund Activity: Q1 2025 in Review

173 of the 7,458 institutional investors tracked by Wall St. Rank reported a position in Kymera Therapeutics (KYMR) for Q1 2025, worth a combined $2B — down 31% from $2.89B a quarter earlier.

Sellers outnumbered buyers: 29 funds closed out of KYMR and 22 opened new positions — a net loss of 7 holders — while 58 trimmed existing stakes and 64 added.

The largest buyer was Avoro Capital Advisors, adding an estimated $47.8M. The largest seller was Avidity Partners Management, exiting entirely with an estimated $20.1M sold.

  • 173 institutional investors held Kymera Therapeutics (KYMR) as of Q1 2025, down from 180 in Q4 2024.
  • Funds reported $2B of Kymera Therapeutics stock for Q1 2025, down 31% quarter-over-quarter.
  • 22 funds opened new Kymera Therapeutics positions in Q1 2025 and 29 closed out, a net change of -7 holders.
  • The largest Kymera Therapeutics buyer in Q1 2025 was Avoro Capital Advisors, an estimated $47.8M added.
  • The largest Kymera Therapeutics seller in Q1 2025 was Avidity Partners Management, an estimated $20.1M sold.

Based on aggregated 13F filings for Q1 2025.