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Kymera Therapeutics

210 hedge funds and large institutions have $4.58B invested in Kymera Therapeutics in 2025 Q3 according to their latest regulatory filings, with 40 funds opening new positions, 81 increasing their positions, 54 reducing their positions, and 38 closing their positions.

New
Increased
Maintained
Reduced
Closed

167% more call options, than puts

Call options by funds: $8.81M | Put options by funds: $3.3M

50% more repeat investments, than reductions

Existing positions increased: 81 | Existing positions reduced: 54

33% more capital invested

Capital invested by funds: $3.44B → $4.58B (+$1.14B)

5% more first-time investments, than exits

New positions opened: 40 | Existing positions closed: 38

0% more funds holding

Funds holding: 210210 (0)

8% less funds holding in top 10

Funds holding in top 10: 1312 (-1)

7.91% less ownership

Funds ownership: 121.01%113.1% (-7.9%)

Holders
210
Holders Change
Holders Change %
0%
% of All Funds
2.76%
Holding in Top 10
12
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-7.69%
% of All Funds
0.16%
New
40
Increased
81
Reduced
54
Closed
38
Calls
$8.81M
Puts
$3.3M
Net Calls
+$5.51M
Net Calls Change
-$1.42M
Name Holding Trade Value Shares
Change
Change in
Stake
DM
26
Deerfield Management
New York
$32.4M -$3.64M -80,742 -12%
Federated Hermes
27
Federated Hermes
Pennsylvania
$31.6M +$25.2M +558,700 New
FCM
28
Frontier Capital Management
Massachusetts
$29.3M +$1.18M +26,247 +5%
AIIC
29
AJU IB Investment Company
South Korea
$25.9M
RSCM
30
Rock Springs Capital Management
Maryland
$25.5M
Charles Schwab
31
Charles Schwab
California
$24.9M +$475K +10,521 +2%
Northern Trust
32
Northern Trust
Illinois
$24.7M +$1.25M +27,767 +7%
Massachusetts Financial Services
33
Massachusetts Financial Services
Massachusetts
$24.6M -$2.39M -52,947 -11%
Two Sigma Investments
34
Two Sigma Investments
New York
$24.3M +$12.2M +270,812 +170%
PCH
35
Polar Capital Holdings
United Kingdom
$22.5M +$6.63M +147,041 +59%
Morgan Stanley
36
Morgan Stanley
New York
$21.4M +$6.32M +140,194 +59%
Two Sigma Advisers
37
Two Sigma Advisers
New York
$21.1M +$6.68M +148,100 +66%
OCA
38
Octagon Capital Advisors
New York
$20.4M +$4.24M +94,000 +35%
Marshall Wace
39
Marshall Wace
United Kingdom
$20.3M +$4.05M +89,792 +33%
Squarepoint
40
Squarepoint
New York
$19.9M +$14.3M +317,922 +954%
Pictet Asset Management
41
Pictet Asset Management
Switzerland
$19.8M +$15.4M +341,259 +6,140%
NI
42
Nextech Invest
Switzerland
$19.3M
DMC
43
Deer Management Company
New York
$18.4M
BCM
44
Boxer Capital Management
California
$18.1M -$5.09M -112,910 -26%
FTM
45
First Turn Management
California
$15.7M +$12.5M +277,726 New
B
46
Braidwell
Connecticut
$15.7M +$12.5M +276,692 New
LGM
47
Logos Global Management
California
$14.2M +$11.3M +250,000 New
WP
48
Woodline Partners
California
$14M -$11.3M -250,111 -50%
GGHC
49
Gilder Gagnon Howe & Co
New York
$14M -$3.71M -82,316 -25%
Adage Capital Partners
50
Adage Capital Partners
Massachusetts
$13.5M -$2.99M -66,200 -22%

KYMR Hedge Fund Activity: Q3 2025 in Review

210 of the 7,621 institutional investors tracked by Wall St. Rank reported a position in Kymera Therapeutics (KYMR) for Q3 2025, worth a combined $4.58B — up 33% from $3.44B a quarter earlier.

Buyers outnumbered sellers: 40 funds opened new KYMR positions and 38 closed out — a net gain of 2 holders — while 81 added to existing stakes and 54 trimmed.

The largest buyer was Holocene Advisors, opening a new position worth an estimated $37.9M. The largest seller was T. Rowe Price Associates, cutting an estimated $79.5M.

  • 210 institutional investors held Kymera Therapeutics (KYMR) as of Q3 2025, unchanged from Q2 2025.
  • Funds reported $4.58B of Kymera Therapeutics stock for Q3 2025, up 33% quarter-over-quarter.
  • 40 funds opened new Kymera Therapeutics positions in Q3 2025 and 38 closed out, a net change of +2 holders.
  • The largest Kymera Therapeutics buyer in Q3 2025 was Holocene Advisors, an estimated $37.9M added.
  • The largest Kymera Therapeutics seller in Q3 2025 was T. Rowe Price Associates, an estimated $79.5M sold.

Based on aggregated 13F filings for Q3 2025.