Jade Biosciences
JBIO
120 hedge funds and large institutions have $700M invested in Jade Biosciences in 2026 Q1 according to their latest regulatory filings, with 29 funds opening new positions, 38 increasing their positions, 33 reducing their positions, and 13 closing their positions.
123% more first-time investments, than exits
New positions opened: 29 | Existing positions closed: 13
20% more funds holding in top 10
Funds holding in top 10: 5 → 6 (+1)
15% more repeat investments, than reductions
Existing positions increased: 38 | Existing positions reduced: 33
14% more funds holding
Funds holding: 105 → 120 (+15)
5.62% more ownership
Funds ownership: 95.46% → 101.08% (+5.6%)
4% less capital invested
Capital invested by funds: $726M → $700M (-$26M)
87% less call options, than puts
Call options by funds: $163K | Put options by funds: $1.23M
Top Buyers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
Janus Henderson Group
London,
|
+$45M |
| 2 |
ACA
Acorn Capital Advisors
New York
|
+$11.4M |
| 3 |
Balyasny Asset Management
Chicago,
Illinois
|
+$5.83M |
| 4 |
FCMV
Foresite Capital Management VI
Larkspur,
California
|
+$4.63M |
| 5 |
IC
Ikarian Capital
Dallas,
Texas
|
+$3.07M |
Top Sellers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
RI
RTW Investments
New York
|
-$12.7M |
| 2 |
BlackRock
New York
|
-$8.06M |
| 3 |
O
OrbiMed
New York
|
-$5.01M |
| 4 |
CM
Caption Management
Oklahoma City,
Oklahoma
|
-$4.58M |
| 5 |
Point72 Asset Management
Stamford,
Connecticut
|
-$4.26M |
JBIO Hedge Fund Activity: Q1 2026 in Review
120 of the 8,191 institutional investors tracked by Wall St. Rank reported a position in Jade Biosciences (JBIO) for Q1 2026, worth a combined $700M — down 3.6% from $726M a quarter earlier.
Buyers outnumbered sellers: 29 funds opened new JBIO positions and 13 closed out — a net gain of 16 holders — while 38 added to existing stakes and 33 trimmed.
The largest buyer was Janus Henderson Group, opening a new position worth an estimated $45M. The largest seller was RTW Investments, cutting an estimated $12.7M.
- 120 institutional investors held Jade Biosciences (JBIO) as of Q1 2026, up from 105 in Q4 2025.
- Funds reported $700M of Jade Biosciences stock for Q1 2026, down 3.6% quarter-over-quarter.
- 29 funds opened new Jade Biosciences positions in Q1 2026 and 13 closed out, a net change of +16 holders.
- The largest Jade Biosciences buyer in Q1 2026 was Janus Henderson Group, an estimated $45M added.
- The largest Jade Biosciences seller in Q1 2026 was RTW Investments, an estimated $12.7M sold.
Based on aggregated 13F filings for Q1 2026.