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Gyre Therapeutics
GYRE

44 hedge funds and large institutions have $23.6M invested in Gyre Therapeutics in 2025 Q4 according to their latest regulatory filings, with 2 funds opening new positions, 23 increasing their positions, 8 reducing their positions, and 6 closing their positions.

New
Increased
Maintained
Reduced
Closed

188% more repeat investments, than reductions

Existing positions increased: 23 | Existing positions reduced: 8

2% more capital invested

Capital invested by funds: $23.1M → $23.6M (+$522K)

0.26% more ownership

Funds ownership: 3.21% → 3.47% (+0.26%)

8% less funds holding

Funds holding: 48 → 44 (-4)

67% less first-time investments, than exits

New positions opened: 2 | Existing positions closed: 6

100% less call options, than puts

Call options by funds: $0 | Put options by funds: $85K

Holders
44
Holders Change
-4
Holders Change %
-8.33%
% of All Funds
0.54%
Holding in Top 10
–
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
–
New
2
Increased
23
Reduced
8
Closed
6
Calls
–
Puts
$85K
Net Calls
-$85K
Net Calls Change
-$85K

Top Buyers

Rank Fund Capital Flow
1
BlackRock
BlackRock
New York
+$470K
2
Vanguard Group
Vanguard Group
Pennsylvania
+$394K
3
Geode Capital Management
Geode Capital Management
Massachusetts
+$375K
4
Charles Schwab
Charles Schwab
California
+$353K
5
Morgan Stanley
Morgan Stanley
New York
+$351K

Top Sellers

Rank Fund Capital Flow
1
Millennium Management
Millennium Management
New York
-$267K
2
Lazard Asset Management
Lazard Asset Management
New York
-$111K
3
State of Wisconsin Investment Board
State of Wisconsin Investment Board
Wisconsin
-$110K
4
UBS Group
UBS Group
Switzerland
-$103K
5
Jane Street
Jane Street
New York
-$100K
Name Holding Trade Value Shares
Change 		Change in
Stake
New York State Common Retirement Fund
26
New York State Common Retirement Fund
New York
$19.1K – – –
BNP Paribas Financial Markets
27
BNP Paribas Financial Markets
France
$18K +$2.99K +388 +18%
PFSRSONJ
28
Police & Firemen's Retirement System of New Jersey
New Jersey
$14.8K – – –
TRCT
29
Tower Research Capital (TRC)
New York
$14.7K -$4.76K -617 -23%
Russell Investments Group
30
Russell Investments Group
United Kingdom
$14.1K +$6.78K +879 +78%
Legal & General Group
31
Legal & General Group
United Kingdom
$9.89K +$4.21K +545 +63%
Simplex Trading
32
Simplex Trading
Illinois
$5.92K +$5.21K +675 +412%
California State Teachers Retirement System (CalSTRS)
33
California State Teachers Retirement System (CalSTRS)
California
$5.13K -$942 -122 -14%
AIP
34
Ameritas Investment Partners
Nebraska
$4.82K – – –
AWM
35
Activest Wealth Management
Florida
$3.76K – – –
AB
36
Amalgamated Bank
New York
$3K +$1K +130 +54%
Citigroup
37
Citigroup
New York
$1.89K -$895 -116 -30%
Optiver Holding
38
Optiver Holding
Netherlands
$1.57K – – –
Nisa Investment Advisors
39
Nisa Investment Advisors
Missouri
$720 – – –
SCM
40
Sterling Capital Management
North Carolina
$417 +$286 +37 +168%
Osaic Holdings
41
Osaic Holdings
Arizona
$268 – – –
SAM
42
Smartleaf Asset Management
Massachusetts
$42 +$46 +6 New
Millennium Management
43
Millennium Management
New York
– -$267K -35,751 Closed
Lazard Asset Management
44
Lazard Asset Management
New York
– -$111K -14,932 Closed
Jane Street
45
Jane Street
New York
– -$100K -12,958 Closed
PS
46
Principal Securities
Iowa
– -$634 -85 Closed
ASN
47
Advisory Services Network
Georgia
– -$492 -66 Closed
AAP
48
Arax Advisory Partners
Colorado
– -$426 -57 Closed
Carson Wealth (CWM LLC)
49
Carson Wealth (CWM LLC)
Nebraska
– -$54 -7 -16%
1
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GYRE Hedge Fund Activity: Q4 2025 in Review

44 of the 8,223 institutional investors tracked by Wall St. Rank reported a position in Gyre Therapeutics (GYRE) for Q4 2025, worth a combined $23.6M — up 2.3% from $23.1M a quarter earlier.

Sellers outnumbered buyers: 6 funds closed out of GYRE and 2 opened new positions — a net loss of 4 holders — while 8 trimmed existing stakes and 23 added.

The largest buyer was BlackRock, adding an estimated $470K. The largest seller was Millennium Management, exiting entirely with an estimated $267K sold.

  • 44 institutional investors held Gyre Therapeutics (GYRE) as of Q4 2025, down from 48 in Q3 2025.
  • Funds reported $23.6M of Gyre Therapeutics stock for Q4 2025, up 2.3% quarter-over-quarter.
  • 2 funds opened new Gyre Therapeutics positions in Q4 2025 and 6 closed out, a net change of -4 holders.
  • The largest Gyre Therapeutics buyer in Q4 2025 was BlackRock, an estimated $470K added.
  • The largest Gyre Therapeutics seller in Q4 2025 was Millennium Management, an estimated $267K sold.

Based on aggregated 13F filings for Q4 2025.