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GOSS

Name Holding Trade Value Shares
Change 		Change in
Stake
OFM
1
Omega Fund Management
Massachusetts
$151M +$145M +6,953,416 New
HIM
2
Hillhouse Investment Management
Cayman Islands
$108M +$104M +4,974,041 New
Capital International Investors
3
Capital International Investors
California
$71M +$68.3M +3,275,851 New
BC
4
Boxer Capital
California
$40.6M +$39.1M +1,875,000 New
AG
5
Artal Group
Luxembourg
$36M +$34.6M +1,658,968 New
AllianceBernstein
6
AllianceBernstein
Tennessee
$30.2M +$29M +1,392,941 New
Vanguard Group
7
Vanguard Group
Pennsylvania
$29.7M +$28.6M +1,372,661 New
Fidelity Investments
8
Fidelity Investments
Massachusetts
$26.6M +$25.6M +1,226,373 New
BG
9
Baupost Group
Massachusetts
$26.1M +$26.4M +1,267,171 New
Citadel Advisors
10
Citadel Advisors
Florida
$21.1M +$20.3M +972,573 New
HA
11
HHLR Advisors
Cayman Islands
$20.3M +$19.6M +937,500 New
Victory Capital Management
12
Victory Capital Management
Texas
$18.6M +$17.9M +860,600 New
BlackRock
13
BlackRock
New York
$17.2M +$16.6M +794,280 New
EC
14
EcoR1 Capital
California
$16.7M +$16.1M +772,096 New
Federated Hermes
15
Federated Hermes
Pennsylvania
$16M +$15.4M +738,000 New
Jennison Associates
16
Jennison Associates
New York
$14.3M +$13.8M +661,116 New
CAM
17
Cormorant Asset Management
Massachusetts
$14.2M +$13.6M +653,129 New
Franklin Resources
18
Franklin Resources
California
$13.5M +$13M +625,000 New
SB
19
Samsara BioCapital
California
$11.5M +$11.1M +532,920 New
CCP
20
Clough Capital Partners
Massachusetts
$10.2M +$10M +480,234 New
Norges Bank
21
Norges Bank
Norway
$10.2M +$9.8M +470,000 New
MWNA
22
Marshall Wace North America
New York
$9.52M +$9.16M +439,461 New
FCM
23
Farallon Capital Management
California
$8.19M +$7.88M +377,852 New
Capital World Investors
24
Capital World Investors
California
$6.76M +$6.51M +312,000 New
RG
25
Redmile Group
California
$5.42M +$5.21M +250,000 New
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