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GOSS

Name Holding Trade Value Shares
Change 		Change in
Stake
OFM
1
Omega Fund Management
Massachusetts
$151M +$145M +86,918 New
HIM
2
Hillhouse Investment Management
Cayman Islands
$108M +$104M +62,176 New
Capital International Investors
3
Capital International Investors
California
$71M +$68.3M +40,948 New
BC
4
Boxer Capital
California
$40.6M +$39.1M +23,438 New
AG
5
Artal Group
Luxembourg
$36M +$34.6M +20,737 New
AllianceBernstein
6
AllianceBernstein
Tennessee
$30.2M +$29M +17,412 New
Vanguard Group
7
Vanguard Group
Pennsylvania
$29.7M +$28.6M +17,158 New
Fidelity Investments
8
Fidelity Investments
Massachusetts
$26.6M +$25.6M +15,330 New
BG
9
Baupost Group
Massachusetts
$26.1M +$26.4M +15,840 New
Citadel Advisors
10
Citadel Advisors
Florida
$21.1M +$20.3M +12,157 New
HA
11
HHLR Advisors
Cayman Islands
$20.3M +$19.6M +11,719 New
Victory Capital Management
12
Victory Capital Management
Texas
$18.6M +$17.9M +10,758 New
BlackRock
13
BlackRock
New York
$17.2M +$16.6M +9,929 New
EC
14
EcoR1 Capital
California
$16.7M +$16.1M +9,651 New
Federated Hermes
15
Federated Hermes
Pennsylvania
$16M +$15.4M +9,225 New
Jennison Associates
16
Jennison Associates
New York
$14.3M +$13.8M +8,264 New
CAM
17
Cormorant Asset Management
Massachusetts
$14.2M +$13.6M +8,164 New
Franklin Resources
18
Franklin Resources
California
$13.5M +$13M +7,813 New
SB
19
Samsara BioCapital
California
$11.5M +$11.1M +6,662 New
CCP
20
Clough Capital Partners
Massachusetts
$10.2M +$10M +6,003 New
Norges Bank
21
Norges Bank
Norway
$10.2M +$9.8M +5,875 New
MWNA
22
Marshall Wace North America
New York
$9.52M +$9.16M +5,493 New
FCM
23
Farallon Capital Management
California
$8.19M +$7.88M +4,723 New
Capital World Investors
24
Capital World Investors
California
$6.76M +$6.51M +3,900 New
RG
25
Redmile Group
California
$5.42M +$5.21M +3,125 New
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