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Guardant Health

364 hedge funds and large institutions have $6.47B invested in Guardant Health in 2025 Q2 according to their latest regulatory filings, with 69 funds opening new positions, 128 increasing their positions, 115 reducing their positions, and 44 closing their positions.

New
Increased
Maintained
Reduced
Closed

57% more first-time investments, than exits

New positions opened: 69 | Existing positions closed: 44

27% more capital invested

Capital invested by funds: $5.1B → $6.47B (+$1.37B)

11% more repeat investments, than reductions

Existing positions increased: 128 | Existing positions reduced: 115

7% more funds holding

Funds holding: 341364 (+23)

3.34% more ownership

Funds ownership: 97%100.34% (+3.3%)

0% more funds holding in top 10

Funds holding in top 10: 66 (0)

30% less call options, than puts

Call options by funds: $89.1M | Put options by funds: $126M

Holders
364
Holders Change
+23
Holders Change %
+6.74%
% of All Funds
4.79%
Holding in Top 10
6
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
0.08%
New
69
Increased
128
Reduced
115
Closed
44
Calls
$89.1M
Puts
$126M
Net Calls
-$37.3M
Net Calls Change
-$4.9M
Name Holding Trade Value Shares
Change
Change in
Stake
Ameriprise
51
Ameriprise
Minnesota
$25.8M +$14.8M +331,823 +204%
N
52
Nuveen
North Carolina
$23.2M +$16.6M +371,783 +497%
MB
53
MPM BioImpact
Massachusetts
$23M
BWLSA
54
Blue Water Life Science Advisors
California
$22.8M -$11.4M -255,000 -37%
EMFAT
55
Emerald Mutual Fund Advisers Trust
Pennsylvania
$21.6M +$3.95M +88,491 +27%
Barclays
56
Barclays
United Kingdom
$20.6M +$6.82M +152,642 +63%
GIP
57
Granite Investment Partners
California
$20.1M -$1.44M -32,138 -8%
TI
58
Trexquant Investment
Connecticut
$19.6M +$8.77M +196,315 +109%
FAM
59
Fred Alger Management
New York
$19.4M -$3.75M -83,938 -18%
CSS
60
Cubist Systematic Strategies
Connecticut
$17.1M +$12M +269,575 +451%
Deutsche Bank
61
Deutsche Bank
Germany
$16.6M -$19.1M -428,517 -57%
Pictet Asset Management
62
Pictet Asset Management
Switzerland
$16.2M -$1.71M -38,252 -11%
Adage Capital Partners
63
Adage Capital Partners
Massachusetts
$16M -$24.1M -539,444 -64%
Massachusetts Financial Services
64
Massachusetts Financial Services
Massachusetts
$15.9M -$7.63M -170,932 -36%
FTM
65
First Turn Management
California
$15.7M -$600K -13,430 -4%
ITP
66
Iron Triangle Partners
Connecticut
$15.6M -$13.4M -300,867 -50%
EGM
67
Engineers Gate Manager
New York
$14.4M +$1.48M +33,167 +14%
Principal Financial Group
68
Principal Financial Group
Iowa
$13.7M -$10.5M -235,607 -47%
Qube Research & Technologies (QRT)
69
Qube Research & Technologies (QRT)
United Kingdom
$13.2M -$2.91M -65,230 -20%
HRCM
70
Hood River Capital Management
Florida
$12.8M +$430K +9,637 +4%
Prudential Financial
71
Prudential Financial
New Jersey
$12.8M -$395K -8,850 -3%
OCM
72
Osterweis Capital Management
California
$12.5M -$2.51M -56,255 -19%
Raymond James Financial
73
Raymond James Financial
Florida
$12.1M +$7.55M +169,110 +266%
Swiss National Bank
74
Swiss National Bank
Switzerland
$11M -$1.21M -27,200 -11%
EHI
75
Eagle Health Investments
Connecticut
$11M +$9.47M +212,000 New

GH Hedge Fund Activity: Q2 2025 in Review

364 of the 7,595 institutional investors tracked by Wall St. Rank reported a position in Guardant Health (GH) for Q2 2025, worth a combined $6.47B — up 27% from $5.1B a quarter earlier.

Buyers outnumbered sellers: 69 funds opened new GH positions and 44 closed out — a net gain of 25 holders — while 128 added to existing stakes and 115 trimmed.

The largest buyer was Millennium Management, adding an estimated $72.6M. The largest seller was Cadian Capital Management, cutting an estimated $63.2M.

  • 364 institutional investors held Guardant Health (GH) as of Q2 2025, up from 341 in Q1 2025.
  • Funds reported $6.47B of Guardant Health stock for Q2 2025, up 27% quarter-over-quarter.
  • 69 funds opened new Guardant Health positions in Q2 2025 and 44 closed out, a net change of +25 holders.
  • The largest Guardant Health buyer in Q2 2025 was Millennium Management, an estimated $72.6M added.
  • The largest Guardant Health seller in Q2 2025 was Cadian Capital Management, an estimated $63.2M sold.

Based on aggregated 13F filings for Q2 2025.