|
1
|
Baker Bros. Advisors
New York
|
–
|
-$1.14B
|
-11,660,432
|
Closed
|
|
|
2
|
Fidelity Investments
Boston,
Massachusetts
|
–
|
-$541M
|
-5,543,741
|
Closed
|
|
|
3
|
Capital Research Global Investors
Los Angeles,
California
|
–
|
-$442M
|
-4,527,358
|
Closed
|
|
|
4
|
Columbia Wanger Asset Management
Chicago,
Illinois
|
–
|
-$317M
|
-3,245,542
|
Closed
|
|
|
5
|
Vanguard Group
Malvern,
Pennsylvania
|
–
|
-$152M
|
-1,554,979
|
Closed
|
|
|
6
|
Capital World Investors
Los Angeles,
California
|
–
|
-$123M
|
-1,262,798
|
Closed
|
|
|
7
|
BlackRock Fund Advisors
San Francisco,
California
|
–
|
-$103M
|
-1,058,768
|
Closed
|
|
|
8
|
T. Rowe Price Associates
Baltimore,
Maryland
|
–
|
-$101M
|
-1,037,935
|
Closed
|
|
|
9
|
BB Biotech
Schaffhausen,
Switzerland
|
–
|
-$100M
|
-1,025,476
|
Closed
|
|
|
10
|
Wells Fargo
San Francisco,
California
|
–
|
-$77.8M
|
-797,807
|
Closed
|
|
|
11
|
BlackRock Institutional Trust
San Francisco,
California
|
–
|
-$59.6M
|
-610,716
|
Closed
|
|
|
12
|
Wellington Management Group
Boston,
Massachusetts
|
–
|
-$57.9M
|
-593,823
|
Closed
|
|
|
13
|
State Street
Boston,
Massachusetts
|
–
|
-$56.9M
|
-583,000
|
Closed
|
|
|
14
|
Janus Henderson Investors US
Denver,
Colorado
|
–
|
-$55.8M
|
-572,037
|
Closed
|
|
|
15
|
AllianceBernstein
Nashville,
Tennessee
|
–
|
-$48M
|
-492,190
|
Closed
|
|
|
16
|
Lord, Abbett & Co
Jersey City,
New Jersey
|
–
|
-$37.9M
|
-388,980
|
Closed
|
|
|
17
|
Eagle Asset Management
St Petersburg,
Florida
|
–
|
-$36.3M
|
-371,816
|
Closed
|
|
|
18
|
Sectoral Asset Management
Montreal,
Quebec, Canada
|
–
|
-$35.7M
|
-365,684
|
Closed
|
|
|
19
|
|
–
|
-$35.5M
|
-364,160
|
Closed
|
|
|
20
|
|
–
|
-$27.9M
|
-286,447
|
Closed
|
|
|
21
|
Northern Trust
Chicago,
Illinois
|
–
|
-$26M
|
-266,963
|
Closed
|
|
|
22
|
|
–
|
-$19.7M
|
-201,582
|
Closed
|
|
|
23
|
Tekla Capital Management
Boston,
Massachusetts
|
–
|
-$19.4M
|
-198,689
|
Closed
|
|
|
24
|
BlackRock Advisors
Wilmington,
Delaware
|
–
|
-$18.2M
|
-187,036
|
Closed
|
|
|
25
|
|
–
|
-$17.2M
|
-176,224
|
Closed
|
|
