Edgewise Therapeutics
EWTX
173 hedge funds and large institutions have $1.82B invested in Edgewise Therapeutics in 2025 Q3 according to their latest regulatory filings, with 18 funds opening new positions, 58 increasing their positions, 62 reducing their positions, and 23 closing their positions.
90% more call options, than puts
Call options by funds: $3.84M | Put options by funds: $2.02M
17% more capital invested
Capital invested by funds: $1.56B → $1.82B (+$259M)
6% less repeat investments, than reductions
Existing positions increased: 58 | Existing positions reduced: 62
3% less funds holding
Funds holding: 178 → 173 (-5)
6.59% less ownership
Funds ownership: 112.87% → 106.28% (-6.6%)
22% less first-time investments, than exits
New positions opened: 18 | Existing positions closed: 23
25% less funds holding in top 10
Funds holding in top 10: 8 → 6 (-2)
Top Buyers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
SL
Siren LLC
Greenwich,
Connecticut
|
+$10.5M |
| 2 |
RCM
RA Capital Management
Boston,
Massachusetts
|
+$7.46M |
| 3 |
IHAM
Integral Health Asset Management
New York
|
+$7.09M |
| 4 |
American Century Companies
Kansas City,
Missouri
|
+$4.43M |
| 5 |
Aberdeen Group
Edinburgh,
United Kingdom
|
+$2.5M |
Top Sellers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
DM
Deerfield Management
New York
|
-$18.5M |
| 2 |
PCH
Polar Capital Holdings
London,
United Kingdom
|
-$12.8M |
| 3 |
WP
Woodline Partners
San Francisco,
California
|
-$12.4M |
| 4 |
PA
Perceptive Advisors
New York
|
-$12M |
| 5 |
Artisan Partners
Milwaukee,
Wisconsin
|
-$9.37M |
EWTX Hedge Fund Activity: Q3 2025 in Review
173 of the 7,621 institutional investors tracked by Wall St. Rank reported a position in Edgewise Therapeutics (EWTX) for Q3 2025, worth a combined $1.82B — up 17% from $1.56B a quarter earlier.
Sellers outnumbered buyers: 23 funds closed out of EWTX and 18 opened new positions — a net loss of 5 holders — while 62 trimmed existing stakes and 58 added.
The largest buyer was Siren LLC, adding an estimated $10.5M. The largest seller was Deerfield Management, cutting an estimated $18.5M.
- 173 institutional investors held Edgewise Therapeutics (EWTX) as of Q3 2025, down from 178 in Q2 2025.
- Funds reported $1.82B of Edgewise Therapeutics stock for Q3 2025, up 17% quarter-over-quarter.
- 18 funds opened new Edgewise Therapeutics positions in Q3 2025 and 23 closed out, a net change of -5 holders.
- The largest Edgewise Therapeutics buyer in Q3 2025 was Siren LLC, an estimated $10.5M added.
- The largest Edgewise Therapeutics seller in Q3 2025 was Deerfield Management, an estimated $18.5M sold.
Based on aggregated 13F filings for Q3 2025.